ADAL

Functionⁱ

Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).By similarity

Cofactorⁱ

Zn²⁺By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	24	Zinc; catalyticBy similarity	1
Metal bindingⁱ	26	Zinc; catalyticBy similarity	1
Binding siteⁱ	26	SubstrateBy similarity	1
Binding siteⁱ	181	Substrate; via amide nitrogen and carbonyl oxygenBy similarity	1
Metal bindingⁱ	208	Zinc; catalyticBy similarity	1
Active siteⁱ	211	Proton donorBy similarity	1
Siteⁱ	232	Important for catalytic activityBy similarity	1
Metal bindingⁱ	293	Zinc; catalyticBy similarity	1
Binding siteⁱ	294	SubstrateBy similarity	1

GO - Molecular functionⁱ

adenosine deaminase activity
Source: Reactome
Inferred from experimentⁱ
- 21755941
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenosine catabolic process Source: GO_Central
drug metabolic process Source: Reactome
inosine biosynthetic process Source: GO_Central
nucleotide metabolic process Source: UniProtKB-KW
purine-containing compound salvage Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Nucleotide metabolism
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2161541 Abacavir metabolism R-HSA-74217 Purine salvage

Reactomeⁱ

R-HSA-2161541 Abacavir metabolism
R-HSA-74217 Purine salvage

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adenosine deaminase-like protein (EC:3.5.4.-)
Gene namesⁱ	Name:ADAL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168803.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31853 ADAL
neXtProtⁱ	NX_Q6DHV7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168803
PharmGKBⁱ	PA142672643

Chemistry databases

ChEMBLⁱ	CHEMBL1795150

ChEMBLⁱ

CHEMBL1795150

Polymorphism and mutation databases

BioMutaⁱ	ADAL
DMDMⁱ	146286026

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000285090	1 – 355	Adenosine deaminase-like proteinAdd BLAST		355

Proteomic databases

EPDⁱ	Q6DHV7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6DHV7
PeptideAtlas More...PeptideAtlasⁱ	Q6DHV7
PRIDEⁱ	Q6DHV7
ProteomicsDBⁱ	66225 66226 [Q6DHV7-2] 66227 [Q6DHV7-3]

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168803 Expressed in 165 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_ADAL
ExpressionAtlasⁱ	Q6DHV7 baseline and differential
Genevisibleⁱ	Q6DHV7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046215 HPA048175

HPAⁱ

HPA046215
HPA048175

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127803, 3 interactors
IntActⁱ	Q6DHV7, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6DHV7
SMRⁱ	Q6DHV7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111081
HOGENOMⁱ	HOG000205847
HOVERGENⁱ	HBG055638
InParanoidⁱ	Q6DHV7
OMAⁱ	RGWFRFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UAU
PhylomeDBⁱ	Q6DHV7
TreeFamⁱ	TF314270

Family and domain databases

InterProⁱ	View protein in InterPro IPR001365 A/AMP_deaminase_dom IPR032466 Metal_Hydrolase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00962 A_deaminase, 1 hit
SUPFAMⁱ	SSF51556 SSF51556, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q6DHV7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD 
        60         70         80         90        100
QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK 
       110        120        130        140        150
YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR 
       160        170        180        190        200
GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK 
       210        220        230        240        250
AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV 
       260        270        280        290        300
RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT 
       310        320        330        340        350
HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP 

RVLHI

Length:355

Mass (Da):40,264

Last modified:May 1, 2007 - v2

Checksum:ⁱ02810E9BC5F56CD5

GO

Isoform 2 (identifier: Q6DHV7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
258-355: ELCLTSNVKS...NHLKPRVLHI → GKAWSFRSSR

« Hide

        10         20         30         40         50
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD 
        60         70         80         90        100
QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK 
       110        120        130        140        150
YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR 
       160        170        180        190        200
GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK 
       210        220        230        240        250
AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV 
       260 
RQHRIPLGKA WSFRSSR

Show »

Length:267

Mass (Da):30,040

Checksum:ⁱC4ED476D40B4C512

GO

Isoform 3 (identifier: Q6DHV7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
185-211: Missing.

« Hide

        10         20         30         40         50
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD 
        60         70         80         90        100
QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK 
       110        120        130        140        150
YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR 
       160        170        180        190        200
GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTIPNQKK ETQILLDLLP 
       210        220        230        240        250
DRIGHGTFLN SGEGGSLDLV DFVRQHRIPL ELCLTSNVKS QTVPSYDQHH 
       260        270        280        290        300
FGFWYSIAHP SVICTDDKGV FATHLSQEYQ LAAETFNLTQ SQVWDLSYES 
       310        320 
INYIFASDST RSELRKKWNH LKPRVLHI

Show »

Length:328

Mass (Da):37,362

Checksum:ⁱF3AE94C2AF38E5FD

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H3BUD6	H3BUD6_HUMAN		Adenosine deaminase-like protein Adenosine deaminase-like protein	ADAL	110	Annotation score:
	H3BQR9	H3BQR9_HUMAN		Adenosine deaminase-like protein Adenosine deaminase-like protein	ADAL	35	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	119	K → E in AK126583 (PubMed:14702039).Curated		1
Sequence conflictⁱ	139	I → T in AK126583 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042782	185 – 211	Missing in isoform 3. 1 PublicationAdd BLAST		27
Alternative sequenceⁱVSP_024821	258 – 355	ELCLT…RVLHI → GKAWSFRSSR in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK126583 mRNA No translation available. AK298870 mRNA Translation: BAG60990.1 AC009852 Genomic DNA No translation available. AC018924 Genomic DNA No translation available. BC075857 mRNA Translation: AAH75857.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32214.1 [Q6DHV7-2] CCDS53936.1 [Q6DHV7-3] CCDS81868.1 [Q6DHV7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001012987.1, NM_001012969.3 [Q6DHV7-2] NP_001152752.1, NM_001159280.2 [Q6DHV7-3] NP_001311293.1, NM_001324364.1 [Q6DHV7-2] NP_001311294.1, NM_001324365.1 [Q6DHV7-2] NP_001311295.1, NM_001324366.1 [Q6DHV7-1] NP_001311297.1, NM_001324368.1 [Q6DHV7-2] XP_011519593.1, XM_011521291.2 [Q6DHV7-1] XP_016877453.1, XM_017021964.1 [Q6DHV7-1] XP_016877454.1, XM_017021965.1 [Q6DHV7-1] XP_016877455.1, XM_017021966.1 [Q6DHV7-1]
UniGeneⁱ	Hs.533913

Genome annotation databases

Ensemblⁱ	ENST00000389651; ENSP00000374302; ENSG00000168803 [Q6DHV7-2] ENST00000422466; ENSP00000398744; ENSG00000168803 [Q6DHV7-3] ENST00000428046; ENSP00000413074; ENSG00000168803 [Q6DHV7-3] ENST00000562188; ENSP00000456242; ENSG00000168803 [Q6DHV7-1] ENST00000610420; ENSP00000478575; ENSG00000168803 [Q6DHV7-2]
GeneIDⁱ	161823
KEGGⁱ	hsa:161823
UCSC genome browser More...UCSCⁱ	uc001zrh.5 human [Q6DHV7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q6DHV7	Adenosine deaminase-like, isoform CRA_a		HUMAN		355	UniRef100_Q6DHV7
UPI0007DC6BB8		HUMAN		320
Q6DHV7-2	ADAL isoform 2		PANTR		267	UniRef100_A0A2J8QEF8
UPI000D0C8BCE		HUMAN		232

Protein	Similar proteins		Species	Score	Length	Source
Q6DHV7	Adenosine deaminase-like, isoform CRA_a		HUMAN		355	UniRef90_Q6DHV7
adenosine deaminase-like protein isoform X1		ODORO		401
adenosine deaminase-like protein		NEOSC		396
Adenosine deaminase like		HORSE		357
Adenosine deaminase like		AILME		356
+99
Q6DHV7-2	ADAL isoform 5		PONAB		267	UniRef90_A0A2J8S5C9
ADAL isoform 2		PANTR		267
UPI000809DCB1		Cebus capucinus imitator		315
UPI000D0C8BCE		HUMAN		232
UPI00020AC70F		NOMLE		267
Q6DHV7-3	adenosine deaminase-like protein isoform X2		ODORO		374	UniRef90_Q6DHV7-3
Adenosine deaminase like		PANPA		329
Adenosine deaminase like		PROCO		329
ADAL isoform 1		PONAB		328
Adenosine deaminase like		SAIBB		328
+24

Protein	Similar proteins		Species	Score	Length	Source
Q6DHV7	Adenosine deaminase-like, isoform CRA_a		HUMAN		355	UniRef50_Q6DHV7
adenosine deaminase-like protein isoform X1		ODORO		401
adenosine deaminase-like protein		NEOSC		396
Adenosine deaminase like		HORSE		357
Adenosine deaminase like		PROCO		356
+224
Q6DHV7-2	Adenosine deaminase like		PONAB		334	UniRef50_H2NN11
cDNA FLJ44620 fis, clone BRACE2013132		HUMAN		240
adenosine deaminase-like protein isoform X3		DELLE		288
Uncharacterized protein		Asian bonytongue		270
adenosine deaminase-like protein		LEPWE		301
+17
Q6DHV7-3	adenosine deaminase-like protein isoform X2		ODORO		374	UniRef50_Q6DHV7-3
Adenosine deaminase like		PROCO		329
Adenosine deaminase like		PANPA		329
Adenosine deaminase like		RHIRO		328
adenosine deaminase-like protein isoform X2		Enhydra lutris kenyoni		328
+32

Entry informationⁱ

Entry nameⁱ	ADAL_HUMAN
Accessionⁱ	Q6DHV7Primary (citable) accession number: Q6DHV7 Secondary accession number(s): A6NHZ3, B4DQM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	May 1, 2007
	Last modified:	September 12, 2018
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q6DHV7 (ADAL_HUMAN)

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Adenosine deaminase-like protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ