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UniProtKB - Q6DHV7 (ADAL_HUMAN)

Entry version 131 (07 Apr 2021)
Sequence version 2 (01 May 2007)
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Protein

Adenosine deaminase-like protein

Gene

ADAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N6-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+2 PublicationsNote: Binds 1 zinc ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=12.5 µM for N6-methyl-AMP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Zinc; catalyticBy similarity1
    Metal bindingi26Zinc; catalyticBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei26N(6)-methyl-AMPBy similarity1
    Binding sitei28N(6)-methyl-AMPBy similarity1
    Binding sitei74N(6)-methyl-AMP; via tele nitrogenBy similarity1
    Binding sitei148N(6)-methyl-AMPBy similarity1
    Binding sitei181N(6)-methyl-AMP; via carbonyl oxygenBy similarity1
    Metal bindingi208Zinc; catalyticBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei211Proton donorBy similarity1
    Binding sitei211N(6)-methyl-AMPBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei232Important for catalytic activityBy similarity1
    Metal bindingi293Zinc; catalyticBy similarity1
    Binding sitei293N(6)-methyl-AMPBy similarity1
    Binding sitei294N(6)-methyl-AMPBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:ENSG00000168803-MONOMER

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q6DHV7

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2161541, Abacavir metabolism
    R-HSA-74217, Purine salvage

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Adenosine deaminase-like protein (EC:3.5.4.-2 Publications)
    Alternative name(s):
    Adenosine deaminase-like protein isoform 11 Publication
    N6-mAMP deaminase1 Publication
    Short name:
    HsMAPDA1 Publication
    N6-methyl-AMP aminohydrolase1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ADAL
    Synonyms:ADAL11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:31853, ADAL

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q6DHV7

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000168803.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...    OpenTargetsi    		ENSG00000168803

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA142672643

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q6DHV7, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL1795150

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		ADAL

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		146286026

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002850901 – 355Adenosine deaminase-like proteinAdd BLAST355

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q6DHV7

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q6DHV7

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q6DHV7

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q6DHV7

    PeptideAtlas

    More...    PeptideAtlasi    		Q6DHV7

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q6DHV7

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		66225 [Q6DHV7-1]
    66226 [Q6DHV7-2]
    66227 [Q6DHV7-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q6DHV7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000168803, Expressed in cardiac muscle of right atrium and 180 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q6DHV7, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q6DHV7, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000168803, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		127803, 4 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q6DHV7, 17 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000398744

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q6DHV7, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q6DHV7

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni106 – 109N(6)-methyl-AMP bindingBy similarity4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1097, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00950000183113

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_039228_6_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q6DHV7

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		RPQFKPY

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q6DHV7

    TreeFam database of animal gene trees

    More...    TreeFami    		TF314270

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR001365, A/AMP_deaminase_dom
    IPR032466, Metal_Hydrolase

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00962, A_deaminase, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF51556, SSF51556, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6DHV7-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD 
            60         70         80         90        100
    QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK 
           110        120        130        140        150
    YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR 
           160        170        180        190        200
    GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK 
           210        220        230        240        250
    AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV 
           260        270        280        290        300
    RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT 
           310        320        330        340        350
    HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP 

    RVLHI
    Length:355
    Mass (Da):40,264
    Last modified:May 1, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02810E9BC5F56CD5
    GO
    Isoform 2 (identifier: Q6DHV7-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         258-355: ELCLTSNVKS...NHLKPRVLHI → GKAWSFRSSR

    Show »
    Length:267
    Mass (Da):30,040
    Checksum:iC4ED476D40B4C512
    GO
    Isoform 3 (identifier: Q6DHV7-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         185-211: Missing.

    Show »
    Length:328
    Mass (Da):37,362
    Checksum:iF3AE94C2AF38E5FD
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H3BUD6H3BUD6_HUMAN
    Adenosine deaminase-like protein
    ADAL
    		110Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H3BQR9H3BQR9_HUMAN
    Adenosine deaminase-like protein
    ADAL
    		35Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti119K → E in AK126583 (PubMed:14702039).Curated1
    Sequence conflicti139I → T in AK126583 (PubMed:14702039).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042782185 – 211Missing in isoform 3. 1 PublicationAdd BLAST27
    Alternative sequenceiVSP_024821258 – 355ELCLT…RVLHI → GKAWSFRSSR in isoform 2. 1 PublicationAdd BLAST98

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AK126583 mRNA No translation available.
    AK298870 mRNA Translation: BAG60990.1
    AC009852 Genomic DNA No translation available.
    AC018924 Genomic DNA No translation available.
    BC075857 mRNA Translation: AAH75857.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS32214.1 [Q6DHV7-2]
    CCDS53936.1 [Q6DHV7-3]
    CCDS81868.1 [Q6DHV7-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001012987.1, NM_001012969.3 [Q6DHV7-2]
    NP_001152752.1, NM_001159280.2 [Q6DHV7-3]
    NP_001311293.1, NM_001324364.1 [Q6DHV7-2]
    NP_001311294.1, NM_001324365.1 [Q6DHV7-2]
    NP_001311295.1, NM_001324366.1 [Q6DHV7-1]
    NP_001311297.1, NM_001324368.1 [Q6DHV7-2]
    XP_011519593.1, XM_011521291.2 [Q6DHV7-1]
    XP_016877453.1, XM_017021964.1 [Q6DHV7-1]
    XP_016877454.1, XM_017021965.1 [Q6DHV7-1]
    XP_016877455.1, XM_017021966.1 [Q6DHV7-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000389651; ENSP00000374302; ENSG00000168803 [Q6DHV7-2]
    ENST00000422466; ENSP00000398744; ENSG00000168803 [Q6DHV7-3]
    ENST00000428046; ENSP00000413074; ENSG00000168803 [Q6DHV7-3]
    ENST00000562188; ENSP00000456242; ENSG00000168803 [Q6DHV7-1]
    ENST00000610420; ENSP00000478575; ENSG00000168803 [Q6DHV7-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		161823

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:161823

    UCSC genome browser

    More...    UCSCi    		uc001zrh.5, human [Q6DHV7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AK126583 mRNA No translation available.
    AK298870 mRNA Translation: BAG60990.1
    AC009852 Genomic DNA No translation available.
    AC018924 Genomic DNA No translation available.
    BC075857 mRNA Translation: AAH75857.1
    CCDSiCCDS32214.1 [Q6DHV7-2]
    CCDS53936.1 [Q6DHV7-3]
    CCDS81868.1 [Q6DHV7-1]
    RefSeqiNP_001012987.1, NM_001012969.3 [Q6DHV7-2]
    NP_001152752.1, NM_001159280.2 [Q6DHV7-3]
    NP_001311293.1, NM_001324364.1 [Q6DHV7-2]
    NP_001311294.1, NM_001324365.1 [Q6DHV7-2]
    NP_001311295.1, NM_001324366.1 [Q6DHV7-1]
    NP_001311297.1, NM_001324368.1 [Q6DHV7-2]
    XP_011519593.1, XM_011521291.2 [Q6DHV7-1]
    XP_016877453.1, XM_017021964.1 [Q6DHV7-1]
    XP_016877454.1, XM_017021965.1 [Q6DHV7-1]
    XP_016877455.1, XM_017021966.1 [Q6DHV7-1]

    3D structure databases

    SMRiQ6DHV7
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi127803, 4 interactors
    IntActiQ6DHV7, 17 interactors
    STRINGi9606.ENSP00000398744

    Chemistry databases

    ChEMBLiCHEMBL1795150

    PTM databases

    iPTMnetiQ6DHV7

    Genetic variation databases

    BioMutaiADAL
    DMDMi146286026

    Proteomic databases

    EPDiQ6DHV7
    jPOSTiQ6DHV7
    MassIVEiQ6DHV7
    MaxQBiQ6DHV7
    PeptideAtlasiQ6DHV7
    PRIDEiQ6DHV7
    ProteomicsDBi66225 [Q6DHV7-1]
    66226 [Q6DHV7-2]
    66227 [Q6DHV7-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		23863, 87 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		161823

    Genome annotation databases

    EnsembliENST00000389651; ENSP00000374302; ENSG00000168803 [Q6DHV7-2]
    ENST00000422466; ENSP00000398744; ENSG00000168803 [Q6DHV7-3]
    ENST00000428046; ENSP00000413074; ENSG00000168803 [Q6DHV7-3]
    ENST00000562188; ENSP00000456242; ENSG00000168803 [Q6DHV7-1]
    ENST00000610420; ENSP00000478575; ENSG00000168803 [Q6DHV7-2]
    GeneIDi161823
    KEGGihsa:161823
    UCSCiuc001zrh.5, human [Q6DHV7-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		161823

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		ADAL
    HGNCiHGNC:31853, ADAL
    HPAiENSG00000168803, Low tissue specificity
    neXtProtiNX_Q6DHV7
    OpenTargetsiENSG00000168803
    PharmGKBiPA142672643
    VEuPathDBiHostDB:ENSG00000168803.14

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1097, Eukaryota
    GeneTreeiENSGT00950000183113
    HOGENOMiCLU_039228_6_0_1
    InParanoidiQ6DHV7
    OMAiRPQFKPY
    PhylomeDBiQ6DHV7
    TreeFamiTF314270

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000168803-MONOMER
    PathwayCommonsiQ6DHV7
    ReactomeiR-HSA-2161541, Abacavir metabolism
    R-HSA-74217, Purine salvage

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		161823, 6 hits in 992 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		ADAL, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		161823
    PharosiQ6DHV7, Tbio

    Protein Ontology

    More...    PROi    		PR:Q6DHV7
    RNActiQ6DHV7, protein

    Gene expression databases

    BgeeiENSG00000168803, Expressed in cardiac muscle of right atrium and 180 other tissues
    ExpressionAtlasiQ6DHV7, baseline and differential
    GenevisibleiQ6DHV7, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR001365, A/AMP_deaminase_dom
    IPR032466, Metal_Hydrolase
    PfamiView protein in Pfam
    PF00962, A_deaminase, 1 hit
    SUPFAMiSSF51556, SSF51556, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADAL_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DHV7
    Secondary accession number(s): A6NHZ3, B4DQM8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: April 7, 2021
    This is version 131 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
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