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Entry version 109 (08 May 2019)
Sequence version 2 (19 Oct 2011)
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Protein

Protein unc-45 homolog B

Gene

unc45b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610). Is necessary for normal early lens development (PubMed:24549050).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone, Developmental protein
Biological processDifferentiation, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein unc-45 homolog BBy similarityImported
Short name:
Unc-45BBy similarity
Alternative name(s):
UNC45-related proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc45bImported
Synonyms:unc45rImported
ORF Names:si:ch211-204d2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-020919-3 unc45b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004129961 – 934Protein unc-45 homolog BAdd BLAST934

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DGE9

PRoteomics IDEntifications database

More...
PRIDEi
Q6DGE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in striated muscle tissue including somites, heart and craniofacial muscle. Detected in mesoderm adjacent to the dorsal midline during the late gastrula stages and in somitic mesoderm during development of trunk skeletal muscle. Also expressed in cranial skeletal muscle and in cardiac and smooth muscle. Detected in somitic muscle and heart primordium of 24 hour embryos. At later stages, expressed in muscles of pectoral fins, jaw, branchial arches and eye.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at the late gastrula stages around 9 hours post-fertilization (hpf). Expression intensifies by the end of gastrulation around 10 hpf, continues into early somitogenesis stages around 12 hpf and persists in the somites until 96 hpf when the somites give rise to the trunk skeletal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000008433 Expressed in 45 organ(s), highest expression level in muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DGE9 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with apobec2a, apobec2b, hsp90a.1, hsp90a.2, hsp90ab1 and myosin.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000023678

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6DGE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati9 – 42TPR 1Sequence analysisAdd BLAST34
Repeati48 – 81TPR 2Sequence analysisAdd BLAST34
Repeati83 – 115TPR 3Sequence analysisAdd BLAST33
Repeati174 – 213ARM 1Sequence analysisAdd BLAST40
Repeati216 – 255ARM 2Sequence analysisAdd BLAST40
Repeati753 – 792ARM 3Sequence analysisAdd BLAST40

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4151 Eukaryota
ENOG410XQNT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285994

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DGE9

KEGG Orthology (KO)

More...
KOi
K21991

Identification of Orthologs from Complete Genome Data

More...
OMAi
LCNAYEK

Database of Orthologous Groups

More...
OrthoDBi
1059433at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6DGE9

TreeFam database of animal gene trees

More...
TreeFami
TF314096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11701 UNC45-central, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 4 hits
SM00028 TPR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6DGE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMGEIGDSV QLKEEGNKHF QAGEIDQAID CYTKAIKTCK KEDKKALAVI
60 70 80 90 100
YRNRSACFLK KENYSNAASD ATKAIDVDAA DIKALYRRCQ AFEKLGKLDM
110 120 130 140 150
AFKDVQRCAT IEPKNKTFLE TLRRLGAEIQ QKLKTTFSTD SRVQNMFDIL
160 170 180 190 200
FSDEPDKEKR EKAANNLIVL AREDAGAERI FQNNGVPLLM QLIDTGKPEM
210 220 230 240 250
ILAAIRTLSG MCTGHRARAT AIIHSVGISK LCSIMAVDNE EIALATANLF
260 270 280 290 300
QCVNDSLSGG DKRNYGKEEA LVLDSSKDLK DILLALLEMI ASKNVSGHGR
310 320 330 340 350
DQALNLLTKN VPRQNKKSTD NSKCLFTIDH GLKKILKVCG QVPDLPDQLP
360 370 380 390 400
MTENTQLIAS VLLSKLYDDL RCDPERDQFR DICDDYIKSK FDPNDMDKNI
410 420 430 440 450
HAINTLSGIL QGPFDLGNVL AGRQGVMEMM VALCGSEREV DQLVAVEALI
460 470 480 490 500
HASTKTSKAS FFISNGVSLL KEMYKKTKNE KIKIRALVGL CKLGSAGGDD
510 520 530 540 550
YSMRQFAEGS TEKLAKQCRK WLCNPTLDVR TRKWAIEGLA YLTNDADVKD
560 570 580 590 600
DFAEDEPAMR AMFELTKSND KTILYAVACT LVNCTNSYDK KEIIPEMVQL
610 620 630 640 650
AKFSKQHVPE QHPKDKKDFI VRRVKRLLKA GVTSALAVMV KADNSILTDQ
660 670 680 690 700
TKEMLARVFL ALTEDVKDRG IIVAQGGGKA LIPLALEGTD KGKIKASHAL
710 720 730 740 750
AKIAAVSNPE IAFPGERIYE VVRPLVSLLG TDRDGMENFE ALRGLTNLAG
760 770 780 790 800
LNDKLRVKIL KEKALPEIEN YMFEDHEQIR QAATECMCNL VCCKEVQDRY
810 820 830 840 850
LEDGNDKLKL LVLLCGEDEE KLQRAAAGAL AMLTAAQKKL AVKMTKVTEQ
860 870 880 890 900
WLEILQRLCI HDNPEIQHRG LVTVFNMLDA DDQLAKKLVE SDMLEILTYV
910 920 930
AKLEDNPKKQ NAIDAARACL SKAMDNGLIK PFSN
Length:934
Mass (Da):103,847
Last modified:October 19, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B30BCCD33EDC562
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QD76E9QD76_DANRE
Protein unc-45 homolog B
unc45b
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH76400 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF330001 mRNA Translation: AAL57031.1
CR847826 Genomic DNA Translation: CAP19503.1
BC076400 mRNA Translation: AAH76400.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_705959.1, NM_153673.2
XP_017212759.1, XM_017357270.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000002164; ENSDARP00000023678; ENSDARG00000008433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
266640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:266640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330001 mRNA Translation: AAL57031.1
CR847826 Genomic DNA Translation: CAP19503.1
BC076400 mRNA Translation: AAH76400.1 Different initiation.
RefSeqiNP_705959.1, NM_153673.2
XP_017212759.1, XM_017357270.1

3D structure databases

SMRiQ6DGE9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000023678

Proteomic databases

PaxDbiQ6DGE9
PRIDEiQ6DGE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000002164; ENSDARP00000023678; ENSDARG00000008433
GeneIDi266640
KEGGidre:266640

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146862
ZFINiZDB-GENE-020919-3 unc45b

Phylogenomic databases

eggNOGiKOG4151 Eukaryota
ENOG410XQNT LUCA
GeneTreeiENSGT00940000157654
HOGENOMiHOG000285994
InParanoidiQ6DGE9
KOiK21991
OMAiLCNAYEK
OrthoDBi1059433at2759
PhylomeDBiQ6DGE9
TreeFamiTF314096

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6DGE9

Gene expression databases

BgeeiENSDARG00000008433 Expressed in 45 organ(s), highest expression level in muscle tissue
ExpressionAtlasiQ6DGE9 baseline

Family and domain databases

Gene3Di1.25.10.10, 2 hits
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR024660 UCS_central_dom
PfamiView protein in Pfam
PF11701 UNC45-central, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 4 hits
SM00028 TPR, 3 hits
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUN45B_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DGE9
Secondary accession number(s): Q8UVX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: May 8, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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