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Protein

Anthrax toxin receptor 2

Gene

Antxr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for cellular interactions with laminin and the extracellular matrix.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Divalent metal cationBy similarity1
Metal bindingi54Divalent metal cationBy similarity1
Metal bindingi118Divalent metal cationBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  • reproductive process Source: MGI
  • toxin transport Source: MGI

Keywordsi

Molecular functionReceptor
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anthrax toxin receptor 2
Gene namesi
Name:Antxr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919164 Antxr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 318ExtracellularSequence analysisAdd BLAST287
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 487CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000269532 – 487Anthrax toxin receptor 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 218By similarity
Modified residuei147PhosphothreonineBy similarity1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6DFX2
PaxDbiQ6DFX2
PRIDEiQ6DFX2

PTM databases

iPTMnetiQ6DFX2
PhosphoSitePlusiQ6DFX2
SwissPalmiQ6DFX2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029338 Expressed in 236 organ(s), highest expression level in decidua
CleanExiMM_ANTXR2
ExpressionAtlasiQ6DFX2 baseline and differential
GenevisibleiQ6DFX2 MM

Interactioni

Subunit structurei

Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner. Binding of PA leads to heptamerization of the receptor-PA complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031281

Structurei

3D structure databases

ProteinModelPortaliQ6DFX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 213VWFAPROSITE-ProRule annotationAdd BLAST170

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi352 – 356Poly-Pro5
Compositional biasi361 – 365Poly-Glu5

Domaini

Binding to PA seems to be effected through the VWA domain.By similarity

Sequence similaritiesi

Belongs to the ATR family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1W Eukaryota
ENOG410YC57 LUCA
GeneTreeiENSGT00430000031214
HOGENOMiHOG000264249
HOVERGENiHBG050514
InParanoidiQ6DFX2
KOiK20909
OMAiERFVSPQ
PhylomeDBiQ6DFX2
TreeFamiTF328943

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR017360 Anthrax_toxin_rcpt
IPR008399 Anthrax_toxin_rcpt_C
IPR008400 Anthrax_toxin_rcpt_extracel
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR16059 PTHR16059, 1 hit
PfamiView protein in Pfam
PF05586 Ant_C, 1 hit
PF05587 Anth_Ig, 1 hit
PF00092 VWA, 1 hit
PIRSFiPIRSF038023 Anthrax_toxin_receptor_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6DFX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAGRSRARS PGSWLFPGLW LLAVGGPGSL LQAQEQPSCK KAFDLYFVLD
60 70 80 90 100
KSGSVANNWI EIYNFVHQLT ERFVSPEMRL SFIVFSSQAT IILPLTGDRY
110 120 130 140 150
KIGKGLEDLK AVKPVGETYI HEGLKLANEQ IQNAGGLKAS SIIIALTDGK
160 170 180 190 200
LDGLVPSYAE NEAKKSRSLG ASVYCVGVLD FEQAQLERIA DSKDQVFPVK
210 220 230 240 250
GGFQALKGII NSILAQSCTE ILELSPSSVC VGEKFQVVLT GRAVTSISHD
260 270 280 290 300
GSVLCTFTAN STYTKSEKPV SIQPSSILCP APVLNKDGET LEVSISYNDG
310 320 330 340 350
KSAVSRSLTI TATECTNGIA AIVAILVLLL LLGAALMWWF WPLCCKVVIK
360 370 380 390 400
DPPPPPSAPM EEEEEDPLPN KKWPTVDASY YGGRGVGGIK RMEVRWGDKG
410 420 430 440 450
STEEGARLEK AKNAVVMVPE EEIPIPSRPP RPRPTHQAPQ TKWYTPIKGR
460 470 480
LDALWALIMK QYDRVSLMRP QEGDEGRCIN FSRVPHQ
Length:487
Mass (Da):53,184
Last modified:August 16, 2004 - v1
Checksum:i61A400D60BC8DE69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JE26A0A0G2JE26_MOUSE
Anthrax toxin receptor
Antxr2
517Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003908 mRNA Translation: AAH03908.1
BC076595 mRNA Translation: AAH76595.1
CCDSiCCDS39177.1
RefSeqiNP_598499.1, NM_133738.1
UniGeneiMm.24842

Genome annotation databases

EnsembliENSMUST00000031281; ENSMUSP00000031281; ENSMUSG00000029338
GeneIDi71914
KEGGimmu:71914
UCSCiuc008yga.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003908 mRNA Translation: AAH03908.1
BC076595 mRNA Translation: AAH76595.1
CCDSiCCDS39177.1
RefSeqiNP_598499.1, NM_133738.1
UniGeneiMm.24842

3D structure databases

ProteinModelPortaliQ6DFX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031281

PTM databases

iPTMnetiQ6DFX2
PhosphoSitePlusiQ6DFX2
SwissPalmiQ6DFX2

Proteomic databases

MaxQBiQ6DFX2
PaxDbiQ6DFX2
PRIDEiQ6DFX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031281; ENSMUSP00000031281; ENSMUSG00000029338
GeneIDi71914
KEGGimmu:71914
UCSCiuc008yga.1 mouse

Organism-specific databases

CTDi118429
MGIiMGI:1919164 Antxr2

Phylogenomic databases

eggNOGiENOG410IK1W Eukaryota
ENOG410YC57 LUCA
GeneTreeiENSGT00430000031214
HOGENOMiHOG000264249
HOVERGENiHBG050514
InParanoidiQ6DFX2
KOiK20909
OMAiERFVSPQ
PhylomeDBiQ6DFX2
TreeFamiTF328943

Miscellaneous databases

ChiTaRSiAntxr2 mouse
PROiPR:Q6DFX2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029338 Expressed in 236 organ(s), highest expression level in decidua
CleanExiMM_ANTXR2
ExpressionAtlasiQ6DFX2 baseline and differential
GenevisibleiQ6DFX2 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR017360 Anthrax_toxin_rcpt
IPR008399 Anthrax_toxin_rcpt_C
IPR008400 Anthrax_toxin_rcpt_extracel
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR16059 PTHR16059, 1 hit
PfamiView protein in Pfam
PF05586 Ant_C, 1 hit
PF05587 Anth_Ig, 1 hit
PF00092 VWA, 1 hit
PIRSFiPIRSF038023 Anthrax_toxin_receptor_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD377005 Anthrax_toxin_rcpt_C, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANTR2_MOUSE
AccessioniPrimary (citable) accession number: Q6DFX2
Secondary accession number(s): Q99L17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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