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Entry version 85 (16 Oct 2019)
Sequence version 2 (20 Dec 2017)
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Protein

Guanine nucleotide exchange C9orf72 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27617292). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27193190, PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (By similarity). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27875531). Plays a role in endosomal trafficking (PubMed:26989253). May be involved in regulating the maturation of phagosomes to lysosomes (PubMed:26989253). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (PubMed:27412785).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processAutophagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide exchange C9orf72 homologCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920455 3110043O21Rik

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Endosome, Lysosome, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Decreased life span (PubMed:27875531, PubMed:27412785). However, another report did not observe any effect on life span (PubMed:26989253). Lymph node and spleen enlargement phenotype accompanied by macrophage infiltration (PubMed:27193190, PubMed:27875531, PubMed:26989253, PubMed:27412785). Severe inflammation also observed in liver (PubMed:27193190, PubMed:27412785). Increased total white blood cell count due to a significant increase in the number of circulating neutrophils (PubMed:27412785). Significantly reduced platelet and red blood cell count (PubMed:27412785). Increased levels of autophagy and lysosomal proteins and autophagy defects in the spleen and liver (PubMed:27193190). Impaired activation of MTOR/mTOR (PubMed:27875531). Massive up-regulation of the cell surface receptor Trem2 (PubMed:26989253). Significantly increased levels of a number of inflammatory chemokines and cytokines (PubMed:26989253, PubMed:27412785). Increased levels of autoantibodies indicative of an autoimmune phenotype (PubMed:27412785). Normal weight gain, sensorimotor coordination, limb strength, femoral motor and sensory axon counts, and muscle electrophysiology (PubMed:26989253). Conditional knockout in neurons and glial cells results in significantly reduced body weight but does not induce motor neuron degeneration, defects in motor function or altered survival (PubMed:26044557).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897121 – 481Guanine nucleotide exchange C9orf72 homologAdd BLAST481

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6DFW0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DFW0

PRoteomics IDEntifications database

More...
PRIDEi
Q6DFW0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6DFW0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DFW0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6DFW0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in postnatal cerebellum and cortex (at protein level). Neuronal expression is detected in several regions of the adult brain and spinal cord (PubMed:26044557). Prominent expression also observed in embryonic and early postnatal neurons including retinal ganglion cells, sensory neurons in the olfactory epithelium and in dorsal root ganglia, and spinal motor neurons (PubMed:26044557). Expressed in the developing cerebral cortex, cerebellum, olfactory bulb, hippocampus and spinal cord in the embryo and in P0 cortical neurons and astrocytes (PubMed:27476503). Also expressed in non-neuronal tissues such as kidney and tooth (PubMed:26044557). In the spleen, highly expressed in myeloid cells compared to B cell and T cell populations where expression is much lower (PubMed:26989253). In the brain, highly expressed in microglia (PubMed:26989253).3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in cerebral cortex and hippocampus at embryonic day 18 and postnatal days 1, 7, 14, 28 and 56.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028300 Expressed in 290 organ(s), highest expression level in adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6DFW0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6DFW0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMCR8; the interaction is direct (PubMed:27875531).

Component of the C9orf72-SMCR8 complex, at least composed of C9orf72, SMCR8 and WDR41 (Probable). The C9orf72-SMCR8 complex associates with the ATG1/ULK1 kinase complex (By similarity).

Interacts with ATG1/ULK1 kinase complex members ULK1, ATG13 and RB1CC1 (By similarity).

Interacts with HNRNPA1, HNRNPA2B1 and UBQLN2 (By similarity).

Interacts with small Rab GTPase RAB1A; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:24549040).

Also interacts with small Rab GTPase RAB7A (PubMed:24549040).

Interacts with cofilin (PubMed:27723745).

Interacts with GTP-binding proteins ARF1 and ARF6 (PubMed:27723745).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3962 C9orf72-SMCR8 complex [Q6DFW0-1]

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000103762

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 194uDENN C9ORF72-typePROSITE-ProRule annotationAdd BLAST172
Domaini200 – 343cDENN C9ORF72-typePROSITE-ProRule annotationAdd BLAST144
Domaini370 – 464dDENN C9ORF72-typePROSITE-ProRule annotationAdd BLAST95

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEBT Eukaryota
ENOG41117RW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231721

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6DFW0

KEGG Orthology (KO)

More...
KOi
K23609

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTHSVPE

Database of Orthologous Groups

More...
OrthoDBi
1434762at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313315

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027819 C9orf72

The PANTHER Classification System

More...
PANTHERi
PTHR31855 PTHR31855, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15019 C9orf72-like, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51835 DENN_C9ORF72, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6DFW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTICPPPSP AVAKTEIALS GESPLLAATF AYWDNILGPR VRHIWAPKTD
60 70 80 90 100
QVLLSDGEIT FLANHTLNGE ILRNAESGAI DVKFFVLSEK GVIIVSLIFD
110 120 130 140 150
GNWNGDRSTY GLSIILPQTE LSFYLPLHRV CVDRLTHIIR KGRIWMHKER
160 170 180 190 200
QENVQKIVLE GTERMEDQGQ SIIPMLTGEV IPVMELLASM KSHSVPEDID
210 220 230 240 250
IADTVLNDDD IGDSCHEGFL LNAISSHLQT CGCSVVVGSS AEKVNKIVRT
260 270 280 290 300
LCLFLTPAER KCSRLCEAES SFKYESGLFV QGLLKDATGS FVLPFRQVMY
310 320 330 340 350
APYPTTHIDV DVNTVKQMPP CHEHIYNQRR YMRSELTAFW RATSEEDMAQ
360 370 380 390 400
DTIIYTDESF TPDLNIFQDV LHRDTLVKAF LDQVFHLKPG LSLRSTFLAQ
410 420 430 440 450
FLLILHRKAL TLIKYIEDDT QKGKKPFKSL RNLKIDLDLT AEGDLNIIMA
460 470 480
LAEKIKPGLH SFIFGRPFYT SVQERDVLMT F
Length:481
Mass (Da):54,278
Last modified:December 20, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5769553C2772049C
GO
Isoform 2 (identifier: Q6DFW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     421-481: Missing.

Show »
Length:420
Mass (Da):47,314
Checksum:iF366D54199127E0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ANZ2A2ANZ2_MOUSE
C9orf72, member of C9orf72-SMCR8 co...
C9orf72 3110043O21Rik, mCG_141727
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti373R → T in BAE39453 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059260421 – 481Missing in isoform 2. Add BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK154817 mRNA Translation: BAE32850.1
AK167354 mRNA Translation: BAE39453.1
AL831776 Genomic DNA No translation available.
CH466538 Genomic DNA Translation: EDL05455.1
CH466538 Genomic DNA Translation: EDL05456.1
BC076612 mRNA Translation: AAH76612.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38708.1 [Q6DFW0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074812.1, NM_001081343.1 [Q6DFW0-1]
XP_006538355.1, XM_006538292.3 [Q6DFW0-1]
XP_006538356.1, XM_006538293.3 [Q6DFW0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084724; ENSMUSP00000081775; ENSMUSG00000028300 [Q6DFW0-2]
ENSMUST00000108127; ENSMUSP00000103762; ENSMUSG00000028300 [Q6DFW0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
73205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73205

UCSC genome browser

More...
UCSCi
uc008sgv.1 mouse
uc008sgw.1 mouse [Q6DFW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154817 mRNA Translation: BAE32850.1
AK167354 mRNA Translation: BAE39453.1
AL831776 Genomic DNA No translation available.
CH466538 Genomic DNA Translation: EDL05455.1
CH466538 Genomic DNA Translation: EDL05456.1
BC076612 mRNA Translation: AAH76612.1
CCDSiCCDS38708.1 [Q6DFW0-1]
RefSeqiNP_001074812.1, NM_001081343.1 [Q6DFW0-1]
XP_006538355.1, XM_006538292.3 [Q6DFW0-1]
XP_006538356.1, XM_006538293.3 [Q6DFW0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-3962 C9orf72-SMCR8 complex [Q6DFW0-1]
STRINGi10090.ENSMUSP00000103762

PTM databases

iPTMnetiQ6DFW0
PhosphoSitePlusiQ6DFW0
SwissPalmiQ6DFW0

Proteomic databases

MaxQBiQ6DFW0
PaxDbiQ6DFW0
PRIDEiQ6DFW0

Genome annotation databases

EnsembliENSMUST00000084724; ENSMUSP00000081775; ENSMUSG00000028300 [Q6DFW0-2]
ENSMUST00000108127; ENSMUSP00000103762; ENSMUSG00000028300 [Q6DFW0-1]
GeneIDi73205
KEGGimmu:73205
UCSCiuc008sgv.1 mouse
uc008sgw.1 mouse [Q6DFW0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
203228
MGIiMGI:1920455 3110043O21Rik

Phylogenomic databases

eggNOGiENOG410IEBT Eukaryota
ENOG41117RW LUCA
GeneTreeiENSGT00390000005644
HOGENOMiHOG000231721
InParanoidiQ6DFW0
KOiK23609
OMAiKTHSVPE
OrthoDBi1434762at2759
TreeFamiTF313315

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6DFW0

Gene expression databases

BgeeiENSMUSG00000028300 Expressed in 290 organ(s), highest expression level in adipose tissue
ExpressionAtlasiQ6DFW0 baseline and differential
GenevisibleiQ6DFW0 MM

Family and domain databases

InterProiView protein in InterPro
IPR027819 C9orf72
PANTHERiPTHR31855 PTHR31855, 1 hit
PfamiView protein in Pfam
PF15019 C9orf72-like, 1 hit
PROSITEiView protein in PROSITE
PS51835 DENN_C9ORF72, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCI072_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DFW0
Secondary accession number(s): A6PWW3, Q3TJP2, Q3U3D8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 20, 2017
Last modified: October 16, 2019
This is version 85 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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