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Entry version 127 (18 Sep 2019)
Sequence version 1 (16 Aug 2004)
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Protein

Rho GTPase-activating protein 21

Gene

Arhgap21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 21
Alternative name(s):
Rho GTPase-activating protein 10
Rho-type GTPase-activating protein 21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap21
Synonyms:Arhgap10, Kiaa1424
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918685 Arhgap21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003052461 – 1944Rho GTPase-activating protein 21Add BLAST1944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineCombined sources1
Modified residuei62PhosphoserineBy similarity1
Modified residuei453PhosphoserineBy similarity1
Modified residuei548Omega-N-methylarginineBy similarity1
Modified residuei568Omega-N-methylarginineCombined sources1
Modified residuei609PhosphoserineBy similarity1
Modified residuei618PhosphoserineBy similarity1
Modified residuei740PhosphothreonineBy similarity1
Modified residuei850PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei874PhosphoserineBy similarity1
Modified residuei875PhosphotyrosineBy similarity1
Modified residuei917PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei947PhosphoserineBy similarity1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1108PhosphoserineBy similarity1
Modified residuei1411PhosphoserineBy similarity1
Modified residuei1425PhosphoserineBy similarity1
Modified residuei1426PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei1503PhosphothreonineBy similarity1
Modified residuei1655PhosphoserineCombined sources1
Modified residuei1668PhosphothreonineCombined sources1
Modified residuei1728PhosphoserineBy similarity1
Modified residuei1901PhosphothreonineCombined sources1
Modified residuei1905PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated with SUMO2 and SUMO3 in proliferating lymphocytes.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6DFV3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6DFV3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6DFV3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6DFV3

PRoteomics IDEntifications database

More...
PRIDEi
Q6DFV3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6DFV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6DFV3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6DFV3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTNNA1 (By similarity).

Interacts with GTP-bound ARF1 and probably ARF6.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
214707, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6DFV3, 4 interactors

Molecular INTeraction database

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MINTi
Q6DFV3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133851

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6DFV3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 164PDZPROSITE-ProRule annotationAdd BLAST110
Domaini924 – 1033PHPROSITE-ProRule annotationAdd BLAST110
Domaini1140 – 1332Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni923 – 1090Interaction with ARF1 and ARF6By similarityAdd BLAST168
Regioni1578 – 1847Interaction with CTNNA1By similarityAdd BLAST270

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD1S Eukaryota
ENOG410YY7B LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082464

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6DFV3

KEGG Orthology (KO)

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KOi
K20315

Database of Orthologous Groups

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OrthoDBi
142586at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q6DFV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATHWTGLPE EDGDKLKACG AASACEVSKN KDGKDQGEPV SPSEDEPFSW
60 70 80 90 100
PGPKTVMLKR TSQGFGFTLR HFIVYPPESA IQFSYKDEEN GNRGGKQRNR
110 120 130 140 150
LEPMDTIFVK QVKEGGPAFE AGLCTGDRII KVNGESVIGK TYSQVIALIQ
160 170 180 190 200
NSDTTLELSV MPKDEDILQV AYSQDAYLKG NEAYSGNARN IPEPPPVCYP
210 220 230 240 250
WLPSTPSATA QPVETCPPDS LPNKQQTSAP VLTQPGRAYR MEIQVPPSPT
260 270 280 290 300
DVAKSNTAVC VCNESVRTVI VPSEKVVDLL ANRNNPSGPS HRTEEVRYGV
310 320 330 340 350
NEQASTKAAS RTTSPASVPT AHLIHQTTGS RSLEPSGILL KSGNYSGHSE
360 370 380 390 400
GISSSRSQAV DSPPVSVNHY SANSHQHIDW KNYKTYKEYI DNRRLHIGCR
410 420 430 440 450
TIQERLDSLR AASQSAADYN QVVPTRTTLQ VRRRSTSHDR VPQSVQIRQR
460 470 480 490 500
SVSQERLEDS VLMKYCPRSA SQGALTSPPV SFNNHRTRSW DYIEGQTEAT
510 520 530 540 550
ATVNSESQIP DSNGERKQTY KWSGFTEQDD RRGIHERPRQ QEMHKPFRGS
560 570 580 590 600
NLTVAPVVNS DNRRLVGRGV GPVSQFKKIP PDLRPPHSNR NFPTTTGVSL
610 620 630 640 650
QRGIAQDRSP LVKVRSNSLK VPPPPVSKPS FSQHSLASMK DQRPVNHLHQ
660 670 680 690 700
HSVLSQQTQF RSESTFEHQL ETEVSSCLPG TSAKTSPQLS ENLGTSDLEL
710 720 730 740 750
PAIPRNGDIN LQEAEIQQPD VLDNKESVIL REKPQSGRQT PQPLRHQSYI
760 770 780 790 800
LAVNDQETGS DTTCWLPNDA RREVHIKRME ERKASSTSPP GDSLASIPFI
810 820 830 840 850
DEPTSPSIDH EIAHIPASAV ISASTAHVPS IATVPPSLTT SAPLIRRQLS
860 870 880 890 900
HDQESVGPPS LDGQHSSKTE RSKSYDEGLD DYREDAKLSF KHVSSLKGIK
910 920 930 940 950
ITDSQKSSED SGSRKGSSSE VFSDAAREGW LQFRPLVTDK GKRVGGSIRP
960 970 980 990 1000
WKQMYVVLRG HSLYLYKDRR EQTTPSEEEQ PISVNACLID ISYSETKRRN
1010 1020 1030 1040 1050
VFRLTTSDCE CLFQAEDRDD MLSWIKTIQE SSNLNEEDTG VTNRDLISRR
1060 1070 1080 1090 1100
IKEYNSLLSK TEQLPKTPRQ SLSIRQTLLG AKSEPKTQSP HSPKEESERK
1110 1120 1130 1140 1150
LLSKDDTSPP KDKGTWRRGI PSIVRKTFEK KPAATGTFGV RLDDCPPAHT
1160 1170 1180 1190 1200
NRYIPLIVDI CCKLVEERGL EYTGIYRVPG NNAAISSMQE ELNKGMADID
1210 1220 1230 1240 1250
IQDDKWRDLN VISSLLKSFF RKLPEPLFTN DKYADFIEAN RKEDPLDRLR
1260 1270 1280 1290 1300
TLKRLIHDLP EHHFETLKFL SAHLKTVAEN SEKNKMEPRN LAIVFGPTLV
1310 1320 1330 1340 1350
RTSEDNMTHM VTHMPDQYKI VETLIQHHDW FFTEEGAEEP LTAVQEENTV
1360 1370 1380 1390 1400
DSQPVPNIDH LLTNIGRTGV LPGDVSDSAT SDSAKSKGSW GSGKDQYSRE
1410 1420 1430 1440 1450
LLVSSIFAAA SRKRKKPKEK AQPSSSEDEL DSVFFKKENT EQSHSEIKEE
1460 1470 1480 1490 1500
SKRESETSGS KQRVVVAKES NTKKDSGTTK EEKKIPWEEP PPPHSSKRNR
1510 1520 1530 1540 1550
SPTLSCRLAM LKEGPRSLLT QKPHCEETGS DSGTLLSTSS QASLLRSSTK
1560 1570 1580 1590 1600
KSTSPETKHS EFLSIAGTTT SDYSTTSSTT YLTSLDSSRL SPEVQSVAES
1610 1620 1630 1640 1650
KGDEADDERS ELVSEGRPVE TDSESEFPVF PTTLTSDRLF RGKFQEVARV
1660 1670 1680 1690 1700
SRRNSEGSEA SCTEGSLTPS LDSRRQQFSS HRLIECDTLS RKKSARFKSD
1710 1720 1730 1740 1750
SGSPGDTRTE KETPALAKMF DVMKKGKSTG SLLTPSRSES EKQEATWKTK
1760 1770 1780 1790 1800
IADRLKLRPR APADDMFGVG NQKPTAETAK RKNIKRRHTL GGHRDATEIS
1810 1820 1830 1840 1850
VLSFWKAHEQ SADKESELSA VNRLKPKCSA QDLSISDWLA RERVRTSASD
1860 1870 1880 1890 1900
LSRGEGLEPQ AESPSVLGTP ISTHSPPSQQ PEARVAATST LASTSQSPLF
1910 1920 1930 1940
TPPQSPDQIN RESFQNMSQN ASSTANIHPH KQSESPDTKA ETPP
Length:1,944
Mass (Da):215,743
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7F832ECD3DBC081
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCJ1B7ZCJ1_MOUSE
Rho GTPase-activating protein 21
Arhgap21
1,955Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCJ0B7ZCJ0_MOUSE
Rho GTPase-activating protein 21
Arhgap21
1,945Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQE8A0A0A0MQE8_MOUSE
Rho GTPase-activating protein 21
Arhgap21
1,949Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UWM5G3UWM5_MOUSE
Rho GTPase-activating protein 21
Arhgap21
1,263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UX38G3UX38_MOUSE
Rho GTPase-activating protein 21
Arhgap21
396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2BHQ2A2BHQ2_MOUSE
Rho GTPase-activating protein 21
Arhgap21
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WQR2F6WQR2_MOUSE
Rho GTPase-activating protein 21
Arhgap21
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM13451 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM16533 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM24301 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1491P → S in AAH43038 (PubMed:19468303).Curated1
Sequence conflicti1491P → S (PubMed:15489334).Curated1
Sequence conflicti1491P → S in BAC65790 (PubMed:12693553).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX649226, AL773540, AL929100 Genomic DNA Translation: CAM13451.1 Sequence problems.
AL773540, AL929100, BX649226 Genomic DNA Translation: CAM16533.1 Sequence problems.
AL929100, AL773540, BX649226 Genomic DNA Translation: CAM24301.1 Sequence problems.
BC043038 mRNA Translation: AAH43038.1
BC076629 mRNA Translation: AAH76629.1
AK122508 Transcribed RNA Translation: BAC65790.1

NCBI Reference Sequences

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RefSeqi
NP_001074833.3, NM_001081364.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
71435

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71435

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649226, AL773540, AL929100 Genomic DNA Translation: CAM13451.1 Sequence problems.
AL773540, AL929100, BX649226 Genomic DNA Translation: CAM16533.1 Sequence problems.
AL929100, AL773540, BX649226 Genomic DNA Translation: CAM24301.1 Sequence problems.
BC043038 mRNA Translation: AAH43038.1
BC076629 mRNA Translation: AAH76629.1
AK122508 Transcribed RNA Translation: BAC65790.1
RefSeqiNP_001074833.3, NM_001081364.3

3D structure databases

SMRiQ6DFV3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi214707, 4 interactors
IntActiQ6DFV3, 4 interactors
MINTiQ6DFV3
STRINGi10090.ENSMUSP00000133851

PTM databases

iPTMnetiQ6DFV3
PhosphoSitePlusiQ6DFV3
SwissPalmiQ6DFV3

Proteomic databases

EPDiQ6DFV3
jPOSTiQ6DFV3
MaxQBiQ6DFV3
PaxDbiQ6DFV3
PRIDEiQ6DFV3

Genome annotation databases

GeneIDi71435
KEGGimmu:71435

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57584
MGIiMGI:1918685 Arhgap21

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410KD1S Eukaryota
ENOG410YY7B LUCA
HOGENOMiHOG000082464
InParanoidiQ6DFV3
KOiK20315
OrthoDBi142586at2759

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arhgap21 mouse

Protein Ontology

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PROi
PR:Q6DFV3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG21_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DFV3
Secondary accession number(s): A2AL67, Q80TD7, Q80XS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: August 16, 2004
Last modified: September 18, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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