UniProtKB - Q6DFV1 (CNDG2_MOUSE)
Condensin-2 complex subunit G2
Ncapg2
Functioni
Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst.
1 PublicationGO - Molecular functioni
- bHLH transcription factor binding Source: MGI
- enzyme activator activity Source: MGI
- histone deacetylase regulator activity Source: MGI
- methylated histone binding Source: MGI
- transmembrane receptor protein tyrosine kinase inhibitor activity Source: MGI
GO - Biological processi
- cell division Source: UniProtKB-KW
- chromosome condensation Source: UniProtKB-KW
- erythrocyte differentiation Source: MGI
- inner cell mass cell proliferation Source: MGI
- mitotic sister chromatid segregation Source: GO_Central
- positive regulation of chromosome segregation Source: ComplexPortal
- positive regulation of chromosome separation Source: ComplexPortal
- transcription by RNA polymerase II Source: MGI
Keywordsi
Biological process | Cell cycle, Cell division, DNA condensation, Mitosis |
Enzyme and pathway databases
Reactomei | R-MMU-2299718, Condensation of Prophase Chromosomes |
Names & Taxonomyi
Protein namesi | Recommended name: Condensin-2 complex subunit G2Alternative name(s): Chromosome-associated protein G2 Short name: CAP-G2 Leucine zipper protein 5 More than blood protein Non-SMC condensin II complex subunit G2 |
Gene namesi | Name:Ncapg2 Synonyms:Luzp5, Mtb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923294, Ncapg2 |
VEuPathDBi | HostDB:ENSMUSG00000042029 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- condensed nuclear chromosome Source: ComplexPortal
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- condensin complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000255943 | 1 – 1138 | Condensin-2 complex subunit G2Add BLAST | 1138 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 30 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1114 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6DFV1 |
MaxQBi | Q6DFV1 |
PaxDbi | Q6DFV1 |
PeptideAtlasi | Q6DFV1 |
PRIDEi | Q6DFV1 |
ProteomicsDBi | 283398 |
PTM databases
iPTMneti | Q6DFV1 |
PhosphoSitePlusi | Q6DFV1 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000042029, Expressed in olfactory epithelium and 262 other tissues |
ExpressionAtlasi | Q6DFV1, baseline and differential |
Genevisiblei | Q6DFV1, MM |
Interactioni
Subunit structurei
Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.
GO - Molecular functioni
- bHLH transcription factor binding Source: MGI
- methylated histone binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 217926, 24 interactors |
ComplexPortali | CPX-986, Condensin II complex |
IntActi | Q6DFV1, 12 interactors |
STRINGi | 10090.ENSMUSP00000081889 |
Miscellaneous databases
RNActi | Q6DFV1, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 459 – 497 | HEATAdd BLAST | 39 |
Phylogenomic databases
eggNOGi | KOG1949, Eukaryota |
GeneTreei | ENSGT00490000043432 |
HOGENOMi | CLU_008117_0_0_1 |
InParanoidi | Q6DFV1 |
OMAi | WGQVGHV |
OrthoDBi | 79594at2759 |
PhylomeDBi | Q6DFV1 |
TreeFami | TF101163 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR024741, Condensin2_G2 |
Pfami | View protein in Pfam PF12422, Condensin2nSMC, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEKREAFIQA VSKELVEEFL QFLQLDKDSS NPFSLSELLD ELSRKQKEEL
60 70 80 90 100
WQRLKDLLTE TLLESPVDRW QTVEVEGADD MESEHSPKMR KSIKIICAIV
110 120 130 140 150
TVILASVSII NEHENYGALL ECAVILNGIL YALPESEQKL QNSIQDLCVK
160 170 180 190 200
WWERGLPAKE DMGKTAFIML LRRSLETKSG ADVCRLWRIH QALYCFDYDW
210 220 230 240 250
EESREIKDML LECFINVNYI KKEEGRRFLS FLFSWNVDFI KMIHETIKNQ
260 270 280 290 300
LAGLQKSLMV HIAEIYFRAW KKASGKMLET IEYDCIQDFM FHGIHLLRRS
310 320 330 340 350
PVHSKVREVL SYFHQQKVRQ GVEEMLYRLY KPILWRGLKA RNSEVRSNAA
360 370 380 390 400
LLFVEAFPIR DPNFTATEMD NEIQKQFEEL YNLIEDPYPR VRSTGILGVC
410 420 430 440 450
KISSKYWEMM PPNILVDFLK KVTGELAFDI SSADVRCSVF KCLPIILDNK
460 470 480 490 500
LSHPLLEQLL PTLRYSLHDN SEKVRVAFVD LLLKIKAVRA AKFWKICPME
510 520 530 540 550
DILVRLEMDS RPVSRRLVSL IFNSFLPVNQ PEEVWCERCV TLIQMNRAAA
560 570 580 590 600
RRFYQYAHEH TASTNIAKLI HVIRHCLNAC IQRTLREGSE AHKECEKENA
610 620 630 640 650
SVLDKTLSVN DTASMAGLLE IIVILWKNIH RSLENNKEAK IYTINKFAAV
660 670 680 690 700
LPEYLKVFKD ERCKIPLFML MSFLPASAVP VFSCGVISVL RNQESVTGRS
710 720 730 740 750
YCTLLDCLCS WGQVGHVLEL IVDWLPTVPP QAKSNLASKR KVEINDTCSV
760 770 780 790 800
KPELALLYME YLLTHPKNRE CLLSVPQKKL NQLLKALEGS KAELESFLQS
810 820 830 840 850
PSGNPLNFNK ATALHAFGLY CRMSVHLQYK FCSEEKIHLS ILDDTGSWLE
860 870 880 890 900
NKVLPLLEDQ EEEYLKLRKD VYQQIIQTYL AVCKDVVMVG LGDPKFQMQL
910 920 930 940 950
LQRSFGIMKT VKGFFYVSLL LGILKEIAGN TIIHKTDSDE KVTVLFDLVQ
960 970 980 990 1000
EVFQKMLECI ACIFRKQPEE SLPLFHSVQT PLHEFITTIQ SWHKDTAVHH
1010 1020 1030 1040 1050
AVLSTLIAAP VVEISHQLQK VSDIEELTSP QCLHDLPPFS RCLVGVIMKS
1060 1070 1080 1090 1100
SDVVRSFVDE LKACVTSGDV EGIVCLTAVL HIILVINKGK HISAKVKEVA
1110 1120 1130
TAVYRKLKTF MEITLEEDSL ERFLYESSMR TLGEFLNP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VLA8 | A0A1Y7VLA8_MOUSE | Condensin-2 complex subunit G2 | Ncapg2 | 111 | Annotation score: | ||
A0A1Y7VP55 | A0A1Y7VP55_MOUSE | Condensin-2 complex subunit G2 | Ncapg2 | 66 | Annotation score: | ||
A0A1Y7VJK1 | A0A1Y7VJK1_MOUSE | Condensin-2 complex subunit G2 | Ncapg2 | 107 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 589 | S → P in AAR21588 (PubMed:14729962).Curated | 1 | |
Sequence conflicti | 674 | L → F in AAH76631 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 723 | D → G in AAR21588 (PubMed:14729962).Curated | 1 | |
Sequence conflicti | 758 | Y → C in AAR21588 (PubMed:14729962).Curated | 1 | |
Sequence conflicti | 1101 | T → A in AAR21588 (PubMed:14729962).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160634 Genomic DNA No translation available. CT030173 Genomic DNA No translation available. BC008539 mRNA Translation: AAH08539.1 Sequence problems. BC076631 mRNA Translation: AAH76631.1 AY455829 mRNA Translation: AAR21588.1 |
CCDSi | CCDS26212.1 |
RefSeqi | NP_598523.3, NM_133762.3 XP_006516412.1, XM_006516349.3 XP_006516413.1, XM_006516350.3 XP_006516414.1, XM_006516351.3 XP_006516415.1, XM_006516352.3 XP_006516416.1, XM_006516353.3 XP_006516417.1, XM_006516354.3 |
Genome annotation databases
Ensembli | ENSMUST00000084828; ENSMUSP00000081889; ENSMUSG00000042029 |
GeneIDi | 76044 |
KEGGi | mmu:76044 |
UCSCi | uc007pht.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160634 Genomic DNA No translation available. CT030173 Genomic DNA No translation available. BC008539 mRNA Translation: AAH08539.1 Sequence problems. BC076631 mRNA Translation: AAH76631.1 AY455829 mRNA Translation: AAR21588.1 |
CCDSi | CCDS26212.1 |
RefSeqi | NP_598523.3, NM_133762.3 XP_006516412.1, XM_006516349.3 XP_006516413.1, XM_006516350.3 XP_006516414.1, XM_006516351.3 XP_006516415.1, XM_006516352.3 XP_006516416.1, XM_006516353.3 XP_006516417.1, XM_006516354.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 217926, 24 interactors |
ComplexPortali | CPX-986, Condensin II complex |
IntActi | Q6DFV1, 12 interactors |
STRINGi | 10090.ENSMUSP00000081889 |
PTM databases
iPTMneti | Q6DFV1 |
PhosphoSitePlusi | Q6DFV1 |
Proteomic databases
EPDi | Q6DFV1 |
MaxQBi | Q6DFV1 |
PaxDbi | Q6DFV1 |
PeptideAtlasi | Q6DFV1 |
PRIDEi | Q6DFV1 |
ProteomicsDBi | 283398 |
Protocols and materials databases
Antibodypediai | 10695, 142 antibodies from 22 providers |
DNASUi | 76044 |
Genome annotation databases
Ensembli | ENSMUST00000084828; ENSMUSP00000081889; ENSMUSG00000042029 |
GeneIDi | 76044 |
KEGGi | mmu:76044 |
UCSCi | uc007pht.1, mouse |
Organism-specific databases
CTDi | 54892 |
MGIi | MGI:1923294, Ncapg2 |
VEuPathDBi | HostDB:ENSMUSG00000042029 |
Phylogenomic databases
eggNOGi | KOG1949, Eukaryota |
GeneTreei | ENSGT00490000043432 |
HOGENOMi | CLU_008117_0_0_1 |
InParanoidi | Q6DFV1 |
OMAi | WGQVGHV |
OrthoDBi | 79594at2759 |
PhylomeDBi | Q6DFV1 |
TreeFami | TF101163 |
Enzyme and pathway databases
Reactomei | R-MMU-2299718, Condensation of Prophase Chromosomes |
Miscellaneous databases
BioGRID-ORCSi | 76044, 20 hits in 65 CRISPR screens |
ChiTaRSi | Ncapg2, mouse |
PROi | PR:Q6DFV1 |
RNActi | Q6DFV1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042029, Expressed in olfactory epithelium and 262 other tissues |
ExpressionAtlasi | Q6DFV1, baseline and differential |
Genevisiblei | Q6DFV1, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR024741, Condensin2_G2 |
Pfami | View protein in Pfam PF12422, Condensin2nSMC, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNDG2_MOUSE | |
Accessioni | Q6DFV1Primary (citable) accession number: Q6DFV1 Secondary accession number(s): E9QP71, Q6SLL0, Q922D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot