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UniProtKB - Q6DEL2 (CLPT1_DANRE)
Protein
Cleft lip and palate transmembrane protein 1 homolog
Gene
clptm1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
May play a role in T-cell development.
By similarityGO - Biological processi
- cell differentiation Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Cleft lip and palate transmembrane protein 1 homolog |
Gene namesi | Name:clptm1 ORF Names:zgc:100803 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040801-265, clptm1 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 352 | ExtracellularSequence analysisAdd BLAST | 352 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 374 – 388 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 389 – 409 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 410 – 414 | ExtracellularSequence analysis | 5 | |
Transmembranei | 415 – 435 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 436 – 475 | CytoplasmicSequence analysisAdd BLAST | 40 | |
Transmembranei | 476 – 496 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 497 – 500 | ExtracellularSequence analysis | 4 | |
Transmembranei | 501 – 521 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 522 – 631 | CytoplasmicSequence analysisAdd BLAST | 110 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245098 | 1 – 631 | Cleft lip and palate transmembrane protein 1 homologAdd BLAST | 631 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 293 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q6DEL2 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 47 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 599 – 631 | DisorderedSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the CLPTM1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2489, Eukaryota |
InParanoidi | Q6DEL2 |
PhylomeDBi | Q6DEL2 |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF0, PTHR21347:SF0, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q6DEL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQETQATQ QSSVSNGEVS SNGAAASGQV AQTGATAQDP QQQQQQQPSA
60 70 80 90 100
WQVIKGVLFR IFIIWAISSW FRRGPSTPDP NTPAGAPRVP SRNLFPKDTL
110 120 130 140 150
MDLYVYISQS EIFTDFNNTE ELFWYQQDLV YGEWTTGDSG DGCYEYYKEL
160 170 180 190 200
DLSESVKQNG SIYMHIYFTK SGFHPDPKRK GQYRRLSTVH ATRMLNKYKR
210 220 230 240 250
RKFLKTKNLL TGETEADPEM IKRAESHGPV EIISHWHPNL TINMVDDHTA
260 270 280 290 300
WVKGSVPPPL DQHVKFDAVS GDYYPIVYFN DYWNLQKDYY PINDTLLNLP
310 320 330 340 350
LRLTYCPLSL WRWQLYAAQS ARSPWNFLGE DTYEQSDEDQ DSVKVALLET
360 370 380 390 400
NPYLLGLTIV VSIVHSIFEF LAFKNDIQFW NSRQSLEGLS VRSIIFGVFQ
410 420 430 440 450
SLVVLLYILD NETNFVVQVS VFIGLLIDFW KITKVMDVRL DRENRIAGIV
460 470 480 490 500
PRLVFKDKST YVESSTKIYD DMAFKYLSWL LYPLFGCYAV YSLLYVEHKG
510 520 530 540 550
WYSWVLSMLY GFLLTFGFIT MTPQLFINYK MKSVAHLPWR MLTYKALNTF
560 570 580 590 600
IDDLFAFVIK MPMMYRIGCL RDDVVFFIYL YQRWIYRVDP NRVNEFGTSG
610 620 630
VDHSKDSSAQ PAAGETPAAI TEKPEGEKKN D
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Q2Y3 | A0A2R8Q2Y3_DANRE | Cleft lip and palate transmembrane ... | clptm1 | 609 | Annotation score: | ||
F1R5K1 | F1R5K1_DANRE | Cleft lip and palate transmembrane ... | clptm1 | 631 | Annotation score: | ||
A0A2R8RYU6 | A0A2R8RYU6_DANRE | Cleft lip and palate transmembrane ... | clptm1 | 632 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077099 mRNA Translation: AAH77099.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077099 mRNA Translation: AAH77099.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000046647 |
Proteomic databases
PaxDbi | Q6DEL2 |
Organism-specific databases
ZFINi | ZDB-GENE-040801-265, clptm1 |
Phylogenomic databases
eggNOGi | KOG2489, Eukaryota |
InParanoidi | Q6DEL2 |
PhylomeDBi | Q6DEL2 |
Miscellaneous databases
PROi | PR:Q6DEL2 |
Family and domain databases
InterProi | View protein in InterPro IPR008429, CLPTM1 IPR030434, CLPTM1L |
PANTHERi | PTHR21347, PTHR21347, 1 hit PTHR21347:SF0, PTHR21347:SF0, 1 hit |
Pfami | View protein in Pfam PF05602, CLPTM1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLPT1_DANRE | |
Accessioni | Q6DEL2Primary (citable) accession number: Q6DEL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families