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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

  • ribosomal large subunit binding Source: GO_Central
  • ribosome binding Source: InterPro
  • translation initiation factor activity Source: UniProtKB-UniRule

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotationImported, IntegrinImported
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6Imported
Synonyms:EIF6UniRule annotation, itgb4bpImported
ORF Names:TEgg004b07.1-001Imported, TNeu062l19.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-868337 eif6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
HOGENOMiHOG000230605
HOVERGENiHBG001300
KOiK03264
OrthoDBiEOG091G0HYF

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DDC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRASFENN NEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSETIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL MVPNNTTDQE LQHIRNSLPD SVRIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TIADQVLVGS
160 170 180 190 200
YCAFSNQGGL LHPKTSIEDQ DELSSLLQVP LVTGTVNRGS EVIAAGMVVN
210 220 230 240
DWSAFCGLDT TSTELSVIES VFKLSDAHPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,606
Last modified:August 16, 2004 - v1
Checksum:i2600CC69C9DB4F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077665 mRNA Translation: AAH77665.1
CR760524 mRNA Translation: CAJ81759.1
CR848359 mRNA Translation: CAJ82882.1
RefSeqiNP_001006884.1, NM_001006883.1
UniGeneiStr.5852

Genome annotation databases

GeneIDi448711
KEGGixtr:448711

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077665 mRNA Translation: AAH77665.1
CR760524 mRNA Translation: CAJ81759.1
CR848359 mRNA Translation: CAJ82882.1
RefSeqiNP_001006884.1, NM_001006883.1
UniGeneiStr.5852

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448711
KEGGixtr:448711

Organism-specific databases

CTDi3692
XenbaseiXB-GENE-868337 eif6

Phylogenomic databases

eggNOGiKOG3185 Eukaryota
COG1976 LUCA
HOGENOMiHOG000230605
HOVERGENiHBG001300
KOiK03264
OrthoDBiEOG091G0HYF

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DDC3_XENTR
AccessioniPrimary (citable) accession number: Q6DDC3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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