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UniProtKB - Q6DD44 (XPR1_XENLA)
Protein
Xenotropic and polytropic retrovirus receptor 1 homolog
Gene
xpr1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 22 | Important for inositol polyphosphate bindingBy similarity | 1 | |
Sitei | 26 | Important for inositol polyphosphate bindingBy similarity | 1 |
GO - Molecular functioni
- efflux transmembrane transporter activity Source: UniProtKB
- inositol hexakisphosphate binding Source: UniProtKB
- phosphate ion transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- cellular phosphate ion homeostasis Source: UniProtKB
- phosphate ion transmembrane transport Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Xenotropic and polytropic retrovirus receptor 1 homolog |
Gene namesi | Name:xpr1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-1015951, xpr1.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- intrinsic component of plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 238 | CytoplasmicSequence analysisAdd BLAST | 238 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 269 | ExtracellularSequence analysis | 10 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 314 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 315 – 335 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 336 – 338 | ExtracellularSequence analysis | 3 | |
Transmembranei | 339 – 359 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 360 – 375 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 376 – 396 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 397 – 401 | ExtracellularSequence analysis | 5 | |
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 423 – 468 | CytoplasmicSequence analysisAdd BLAST | 46 | |
Transmembranei | 469 – 491 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 492 – 503 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 504 – 524 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 525 – 692 | CytoplasmicSequence analysisAdd BLAST | 168 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315861 | 1 – 692 | Xenotropic and polytropic retrovirus receptor 1 homologAdd BLAST | 692 |
Proteomic databases
PRIDEi | Q6DD44 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 177 | SPXPROSITE-ProRule annotationAdd BLAST | 177 | |
Domaini | 435 – 639 | EXSPROSITE-ProRule annotationAdd BLAST | 205 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 158 – 165 | Important for inositol polyphosphate bindingBy similarity | 8 | |
Regioni | 660 – 692 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 671 – 692 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Domaini
The SPX domain has high affinity for inositol polyphosphates, such as myo-inositol hexakisphosphate and 5-diphospho-myo-inositol pentakisphosphate (5-InsP7). Its affinity for inorganic phosphate is tow to three orders of magnitude lower.By similarity
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | GNWTEAR |
OrthoDBi | 536327at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004342, EXS_C IPR004331, SPX_dom |
Pfami | View protein in Pfam PF03124, EXS, 1 hit PF03105, SPX, 2 hits |
PROSITEi | View protein in PROSITE PS51380, EXS, 1 hit PS51382, SPX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6DD44-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFTEHLSAH ITPEWRKQYI QYEAFKEMLY AAQDQAPSIE VTDEDTVKRY
60 70 80 90 100
YAKFEEKFFQ TCEKELAKIN TFYSEKLAEA QRRSATLQNE LQSSLDAQRE
110 120 130 140 150
SSVVPGLRQR RKAVFALTHE ERVQHRNIKD LKLAFSEFYL SLILLQNYQN
160 170 180 190 200
LNFTGFRKIL KKHDKILETS RGADWRVAHV EVAPFYTCKK INQLISETET
210 220 230 240 250
VVTNELESGD RQKAMKRLRV PPLGAAQPAP AWTTFRVGLY CGIFMVVNLA
260 270 280 290 300
VVMAGYHFLQ GKNVWPMVRI YRGGFLLIEF LFLLGINTYG WRQAGVNHVL
310 320 330 340 350
IFELNPRNNL SHQHLFEIAG FLGILWCFSL FSCIFGLSIN LQMHLNPLIL
360 370 380 390 400
YGIMLVFLVN PTKTFYYKSR FWLLKLLFRV FTAPFHKVGF ADFWLADQLN
410 420 430 440 450
SLAIILMDLE FMICFYSFEL NWGKSEGLVE SAKSVCNSYS YGVRAVVQCI
460 470 480 490 500
PAWLRFIQCL RRYRDTKRAF PHLVNAGKYS TTFFMVTFAA LYSTHKERNH
510 520 530 540 550
SDAQVFFYLW IVFYFISSCY TLIWDLKMDW GLFDRNAGEN TFLREEIVYP
560 570 580 590 600
QKAYYYCAII QDVILRFAWT IQISVTSLNL FTDAGDVIST VLAPLEVFRR
610 620 630 640 650
FVWNFFRLEN EHLNNCGEFR AVRDISVAPL NADDQTMLEQ MMDQDDGVKN
660 670 680 690
RVKSRIWKRS QSMSLRRPRL SSQSKMKDAK ILIDDTDDEA NT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077785 mRNA Translation: AAH77785.1 |
RefSeqi | NP_001086930.1, NM_001093461.1 |
Genome annotation databases
GeneIDi | 446765 |
KEGGi | xla:446765 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077785 mRNA Translation: AAH77785.1 |
RefSeqi | NP_001086930.1, NM_001093461.1 |
3D structure databases
SMRi | Q6DD44 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q6DD44 |
Protocols and materials databases
DNASUi | 446765 |
Genome annotation databases
GeneIDi | 446765 |
KEGGi | xla:446765 |
Organism-specific databases
CTDi | 446765 |
Xenbasei | XB-GENE-1015951, xpr1.L |
Phylogenomic databases
OMAi | GNWTEAR |
OrthoDBi | 536327at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004342, EXS_C IPR004331, SPX_dom |
Pfami | View protein in Pfam PF03124, EXS, 1 hit PF03105, SPX, 2 hits |
PROSITEi | View protein in PROSITE PS51380, EXS, 1 hit PS51382, SPX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XPR1_XENLA | |
Accessioni | Q6DD44Primary (citable) accession number: Q6DD44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | August 16, 2004 | |
Last modified: | September 29, 2021 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |