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UniProtKB - Q6DD21 (CBPC1_XENLA)
Protein
Cytosolic carboxypeptidase 1
Gene
agtpbp1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.
By similarityCatalytic activityi
- (L-glutamyl)(n+1)-γ-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-γ-L-glutamyl-L-glutamyl-[protein] + L-glutamateBy similarityThis reaction proceeds in the forwardBy similarity direction.
- C-terminal L-α-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-α-aminoacyl-L-glutamyl-[tubulin] + L-glutamateBy similarityEC:3.4.17.24By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 914 | ZincBy similarity | 1 | |
Metal bindingi | 917 | ZincBy similarity | 1 | |
Active sitei | 964 | NucleophileBy similarity | 1 | |
Metal bindingi | 1011 | ZincBy similarity | 1 |
GO - Molecular functioni
- metallocarboxypeptidase activity Source: UniProtKB
- tubulin binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- cerebellar Purkinje cell differentiation Source: UniProtKB
- C-terminal protein deglutamylation Source: UniProtKB
- eye photoreceptor cell differentiation Source: UniProtKB
- mitochondrion organization Source: UniProtKB
- neuromuscular process Source: UniProtKB
- olfactory bulb development Source: UniProtKB
- protein side chain deglutamylation Source: UniProtKB
Keywordsi
Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:agtpbp1 Synonyms:ccp1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-5932611, agtpbp1.L |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- Mitochondrion By similarity
Cytoplasm and Cytosol
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308693 | 1 – 1225 | Cytosolic carboxypeptidase 1Add BLAST | 1225 |
Proteomic databases
MaxQBi | Q6DD21 |
Interactioni
GO - Molecular functioni
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 103853, 1 interactor |
IntActi | Q6DD21, 1 interactor |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 366 – 398 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1181 – 1225 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 366 – 388 | Acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1181 – 1208 | Acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the peptidase M14 family.Curated
Phylogenomic databases
OMAi | HVATCGN |
OrthoDBi | 481670at2759 |
Family and domain databases
CDDi | cd06906, M14_Nna1, 1 hit |
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR033852, CBPC1/4 IPR040626, Pepdidase_M14_N IPR000834, Peptidase_M14 |
Pfami | View protein in Pfam PF18027, Pepdidase_M14_N, 1 hit PF00246, Peptidase_M14, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6DD21-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKVKATAEK CQLNISRIQS LLSQLEKVNA ESLLFDTDNT RYVTAKIFHL
60 70 80 90 100
AQTQEKTRKE MTAKGSTGIE VILCTLENTR DLQTILNILN ILNELASTAG
110 120 130 140 150
GRRINALISK GGARILLQLL LSASKESPSN EELMIVLHSL LAKLGPKDKK
160 170 180 190 200
FGVKARVSGA LNISLNLVKQ NLQNPRLILP CLQVLRVCCM NSVNSAYLGK
210 220 230 240 250
NGAVEILFKI IGPFTRRNTG LIKVSLDTLA ALLKSRTNAR KAVDRAYVQT
260 270 280 290 300
LISTYMDWHR HDTRHRHMLI RKGILQCLKS ITNIKIGRKA FIDANGMKTL
310 320 330 340 350
YNTSQECQAV RTLDPLVNTS SLIMRKCFPK NRLPLPTIKS AFQFQLPFMP
360 370 380 390 400
TSGPVALLYS MPPEVDDVVD ESDDNEDTDA ETEAEAENED SDQICKNDDI
410 420 430 440 450
ETDITKLIPG QELGRTLEDL KMYERFFPEL TEDFQEFDLV SNEPKPGAKL
460 470 480 490 500
GPIIVPTAGE EQPEVPNNFM KNLARRSCNI SLEDESNQRP TFLDMSKNVT
510 520 530 540 550
NKGNSLDQKV HVDKDGSCYY YSNDIVRDLE KLSLHKASGN HPCRNGCVSA
560 570 580 590 600
KDKPNFLPHP CNKSTSSSIS CSNSLFEKHS MHLGPLCCSG IAPDDDESSP
610 620 630 640 650
LDEQVMREMT DFDSILPLHD PDLYIEIVKN TKSVPEYTEV AYPDYFGHVP
660 670 680 690 700
PFFKERLLER PYGVQRSKIF QDIERMIHPN DIIDRVIYDL DNPSCSAHDE
710 720 730 740 750
IDILKFNSKF ESGNLRKVIQ IRKNEYDLIL NSDINSNHYH QWFYFEVSGM
760 770 780 790 800
RTGVAYRFNI INCEKSNSQF NYGMQPLMYS VQEALASRPW WYRVGTDICY
810 820 830 840 850
YKNHFSRSSL ATGGQKGKSY YTITFTVTFP HKDDVCYFAY HYPYTYSTLK
860 870 880 890 900
MHLQKLESLH SPQQIYFRQE VLCETLGGNG CPVITITAMP ESNYYEHVYQ
910 920 930 940 950
FRNRPYIFLT SRVHPGETNA SWVMKGTLEF LMGSSATAQS LRESYIFKIV
960 970 980 990 1000
PMLNPDGVIN GNHRCSLSGE DLNRQWQNPN SDLHPTIYHT KGLLQYLSAI
1010 1020 1030 1040 1050
KRVPLVYCDY HGHSRKKNVF MYGCSIKETV WHTNANAASC DMVEESGYKT
1060 1070 1080 1090 1100
LPKVLNQIAP AFSMSSCSFV VEKSKESTAR VVVWKEIGVQ RSYTMESTLC
1110 1120 1130 1140 1150
GCDQGKYKDL QIGTKELEEM GAKFCVGLLR LKRLTSPMEL TLPPSLIDIE
1160 1170 1180 1190 1200
NELIESSCKV ASPTTYVLED DEPRFIEEVD YSAESNDDVD PDLPENIGDF
1210 1220
ETSTLEEESF SDSEITRTHM SGQST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077808 mRNA Translation: AAH77808.1 |
RefSeqi | NP_001087104.1, NM_001093635.1 |
Genome annotation databases
GeneIDi | 446993 |
KEGGi | xla:446993 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077808 mRNA Translation: AAH77808.1 |
RefSeqi | NP_001087104.1, NM_001093635.1 |
3D structure databases
SMRi | Q6DD21 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 103853, 1 interactor |
IntActi | Q6DD21, 1 interactor |
Proteomic databases
MaxQBi | Q6DD21 |
Protocols and materials databases
DNASUi | 446993 |
Genome annotation databases
GeneIDi | 446993 |
KEGGi | xla:446993 |
Organism-specific databases
CTDi | 446993 |
Xenbasei | XB-GENE-5932611, agtpbp1.L |
Phylogenomic databases
OMAi | HVATCGN |
OrthoDBi | 481670at2759 |
Family and domain databases
CDDi | cd06906, M14_Nna1, 1 hit |
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR033852, CBPC1/4 IPR040626, Pepdidase_M14_N IPR000834, Peptidase_M14 |
Pfami | View protein in Pfam PF18027, Pepdidase_M14_N, 1 hit PF00246, Peptidase_M14, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CBPC1_XENLA | |
Accessioni | Q6DD21Primary (citable) accession number: Q6DD21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families