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UniProtKB - Q6DD21 (CBPC1_XENLA)

Entry version 71 (23 Feb 2022)
Sequence version 1 (16 Aug 2004)
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Protein

Cytosolic carboxypeptidase 1

Gene

agtpbp1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi914ZincBy similarity1
Metal bindingi917ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei964NucleophileBy similarity1
Metal bindingi1011ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytosolic carboxypeptidase 1By similarity (EC:3.4.17.-By similarity, EC:3.4.17.24By similarity)
Alternative name(s):
ATP/GTP-binding protein 1By similarity
Protein deglutamylase CCP1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:agtpbp1
Synonyms:ccp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-5932611, agtpbp1.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003086931 – 1225Cytosolic carboxypeptidase 1Add BLAST1225

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6DD21

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		103853, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q6DD21, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6DD21

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni366 – 398DisorderedSequence analysisAdd BLAST33
Regioni1181 – 1225DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi366 – 388Acidic residuesSequence analysisAdd BLAST23
Compositional biasi1181 – 1208Acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		HVATCGN

Database of Orthologous Groups

More...OrthoDBi		481670at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd06906, M14_Nna1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033852, CBPC1/4
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6DD21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVKATAEK CQLNISRIQS LLSQLEKVNA ESLLFDTDNT RYVTAKIFHL 
        60         70         80         90        100
AQTQEKTRKE MTAKGSTGIE VILCTLENTR DLQTILNILN ILNELASTAG 
       110        120        130        140        150
GRRINALISK GGARILLQLL LSASKESPSN EELMIVLHSL LAKLGPKDKK 
       160        170        180        190        200
FGVKARVSGA LNISLNLVKQ NLQNPRLILP CLQVLRVCCM NSVNSAYLGK 
       210        220        230        240        250
NGAVEILFKI IGPFTRRNTG LIKVSLDTLA ALLKSRTNAR KAVDRAYVQT 
       260        270        280        290        300
LISTYMDWHR HDTRHRHMLI RKGILQCLKS ITNIKIGRKA FIDANGMKTL 
       310        320        330        340        350
YNTSQECQAV RTLDPLVNTS SLIMRKCFPK NRLPLPTIKS AFQFQLPFMP 
       360        370        380        390        400
TSGPVALLYS MPPEVDDVVD ESDDNEDTDA ETEAEAENED SDQICKNDDI 
       410        420        430        440        450
ETDITKLIPG QELGRTLEDL KMYERFFPEL TEDFQEFDLV SNEPKPGAKL 
       460        470        480        490        500
GPIIVPTAGE EQPEVPNNFM KNLARRSCNI SLEDESNQRP TFLDMSKNVT 
       510        520        530        540        550
NKGNSLDQKV HVDKDGSCYY YSNDIVRDLE KLSLHKASGN HPCRNGCVSA 
       560        570        580        590        600
KDKPNFLPHP CNKSTSSSIS CSNSLFEKHS MHLGPLCCSG IAPDDDESSP 
       610        620        630        640        650
LDEQVMREMT DFDSILPLHD PDLYIEIVKN TKSVPEYTEV AYPDYFGHVP 
       660        670        680        690        700
PFFKERLLER PYGVQRSKIF QDIERMIHPN DIIDRVIYDL DNPSCSAHDE 
       710        720        730        740        750
IDILKFNSKF ESGNLRKVIQ IRKNEYDLIL NSDINSNHYH QWFYFEVSGM 
       760        770        780        790        800
RTGVAYRFNI INCEKSNSQF NYGMQPLMYS VQEALASRPW WYRVGTDICY 
       810        820        830        840        850
YKNHFSRSSL ATGGQKGKSY YTITFTVTFP HKDDVCYFAY HYPYTYSTLK 
       860        870        880        890        900
MHLQKLESLH SPQQIYFRQE VLCETLGGNG CPVITITAMP ESNYYEHVYQ 
       910        920        930        940        950
FRNRPYIFLT SRVHPGETNA SWVMKGTLEF LMGSSATAQS LRESYIFKIV 
       960        970        980        990       1000
PMLNPDGVIN GNHRCSLSGE DLNRQWQNPN SDLHPTIYHT KGLLQYLSAI 
      1010       1020       1030       1040       1050
KRVPLVYCDY HGHSRKKNVF MYGCSIKETV WHTNANAASC DMVEESGYKT 
      1060       1070       1080       1090       1100
LPKVLNQIAP AFSMSSCSFV VEKSKESTAR VVVWKEIGVQ RSYTMESTLC 
      1110       1120       1130       1140       1150
GCDQGKYKDL QIGTKELEEM GAKFCVGLLR LKRLTSPMEL TLPPSLIDIE 
      1160       1170       1180       1190       1200
NELIESSCKV ASPTTYVLED DEPRFIEEVD YSAESNDDVD PDLPENIGDF 
      1210       1220 
ETSTLEEESF SDSEITRTHM SGQST
Length:1,225
Mass (Da):138,782
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D560A9F5D0513B3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC077808 mRNA Translation: AAH77808.1

NCBI Reference Sequences

More...RefSeqi		NP_001087104.1, NM_001093635.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		446993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:446993

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077808 mRNA Translation: AAH77808.1
RefSeqiNP_001087104.1, NM_001093635.1

3D structure databases

SMRiQ6DD21
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi103853, 1 interactor
IntActiQ6DD21, 1 interactor

Proteomic databases

MaxQBiQ6DD21

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		446993

Genome annotation databases

GeneIDi446993
KEGGixla:446993

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		446993
XenbaseiXB-GENE-5932611, agtpbp1.L

Phylogenomic databases

OMAiHVATCGN
OrthoDBi481670at2759

Family and domain databases

CDDicd06906, M14_Nna1, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR033852, CBPC1/4
IPR040626, Pepdidase_M14_N
IPR000834, Peptidase_M14
PfamiView protein in Pfam
PF18027, Pepdidase_M14_N, 1 hit
PF00246, Peptidase_M14, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBPC1_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DD21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 16, 2004
Last modified: February 23, 2022
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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