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UniProtKB - Q6DCE8 (CTR2_XENLA)
Protein
Cationic amino acid transporter 2
Gene
slc7a2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
By similarityGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- amino acid transport Source: UniProtKB-KW
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cationic amino acid transporter 2Short name: CAT-2 Short name: CAT2 Alternative name(s): Low affinity cationic amino acid transporter 2 Solute carrier family 7 member 2 |
Gene namesi | Name:slc7a2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5763998, slc7a2.2.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | CytoplasmicSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 66 | ExtracellularSequence analysis | 7 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 88 – 104 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 105 – 125 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 126 – 163 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 192 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 249 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 271 – 288 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 310 – 340 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 341 – 361 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 362 – 386 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 387 – 407 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 409 | ExtracellularSequence analysis | 2 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 473 | CytoplasmicSequence analysisAdd BLAST | 43 | |
Transmembranei | 474 – 494 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 495 – 501 | ExtracellularSequence analysis | 7 | |
Transmembranei | 502 – 522 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 523 – 532 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 533 – 553 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 554 – 559 | ExtracellularSequence analysis | 6 | |
Transmembranei | 560 – 580 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 581 – 622 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375230 | 1 – 622 | Cationic amino acid transporter 2Add BLAST | 622 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 234 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OMAi | YGLFMCL |
OrthoDBi | 439017at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6DCE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPYEGLYSF YKILTRTKHV TLEGTGSSDL CRCLSTLDLV ALGVGSTLGA
60 70 80 90 100
GVYVLAGEVA KVDSGPSIII SFLIAALASV LAGLCYAEFG ARVPLTGSAY
110 120 130 140 150
LYSYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSATFDE LVGKKIGNFL
160 170 180 190 200
GNTMHMDLPG LAEYPDIFAV CLIILLAGLL SFGVKESTAV NKVFTAINIL
210 220 230 240 250
VLLFVIASGC VTGNLKYWKM SKEDLWATKQ SVSNHSIGNE TGLDFGAGGF
260 270 280 290 300
MPFGFSGTLA GAATCFYAFV GFDCIATTGE EVKNPQKSIP LGIVLSLSIC
310 320 330 340 350
FFAYFGVSAS LTLMMPYHLL DSQSPLPAAF EYVGWNVAKY IVAVGSLCAL
360 370 380 390 400
TTSLLGSMFP MPRILFAMAR DGLLFQPLSR VSSRQSPVIA TIVSGVVAAL
410 420 430 440 450
MAFLFNLKAL VDMMSIGTLL AYTLVSTCVL LLRYQPQTDF GKSPDGNLQE
460 470 480 490 500
QNISSISHLP ETPSVHSSAL VTRCVIAITL LVCVASVVST VGSQCLLSGR
510 520 530 540 550
AWCLSLLVLS LLGIIIALVI IWRQPQNQSK ATFMVPFVPV LPVVSILVNI
560 570 580 590 600
YLMVQLSTDT WLRYAVWMAV GFVIYFGYGI RHSIERLHLK ETCTQKMAIS
610 620
STETLCKAQC LELQLGEAKP MD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078099 mRNA Translation: AAH78099.1 |
RefSeqi | NP_001087158.1, NM_001093689.1 |
Genome annotation databases
GeneIDi | 447047 |
KEGGi | xla:447047 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078099 mRNA Translation: AAH78099.1 |
RefSeqi | NP_001087158.1, NM_001093689.1 |
3D structure databases
AlphaFoldDBi | Q6DCE8 |
SMRi | Q6DCE8 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 447047 |
Genome annotation databases
GeneIDi | 447047 |
KEGGi | xla:447047 |
Organism-specific databases
CTDi | 447047 |
Xenbasei | XB-GENE-5763998, slc7a2.2.L |
Phylogenomic databases
OMAi | YGLFMCL |
OrthoDBi | 439017at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR002293, AA/rel_permease1 IPR004755, Cat_AA_permease IPR029485, CAT_C |
Pfami | View protein in Pfam PF13520, AA_permease_2, 1 hit PF13906, AA_permease_C, 1 hit |
TIGRFAMsi | TIGR00906, 2A0303, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CTR2_XENLA | |
Accessioni | Q6DCE8Primary (citable) accession number: Q6DCE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families