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UniProtKB - Q6DCE8 (CTR2_XENLA)

Entry version 76 (08 May 2019)
Sequence version 1 (16 Aug 2004)
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Protein

Cationic amino acid transporter 2

Gene

slc7a2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 2
Short name:
CAT-2
Short name:
CAT2
Alternative name(s):
Low affinity cationic amino acid transporter 2
Solute carrier family 7 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc7a2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-5763998 slc7a2.2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 66ExtracellularSequence analysis7
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 163ExtracellularSequence analysisAdd BLAST38
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 192CytoplasmicSequence analysis8
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 249ExtracellularSequence analysisAdd BLAST36
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 288CytoplasmicSequence analysisAdd BLAST18
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 340ExtracellularSequence analysisAdd BLAST31
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 386CytoplasmicSequence analysisAdd BLAST25
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 409ExtracellularSequence analysis2
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 473CytoplasmicSequence analysisAdd BLAST43
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 501ExtracellularSequence analysis7
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 532CytoplasmicSequence analysis10
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 559ExtracellularSequence analysis6
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Topological domaini581 – 622CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003752301 – 622Cationic amino acid transporter 2Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q6DCE8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...KOi		K13864

Database of Orthologous Groups

More...OrthoDBi		439017at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF006060 AA_transporter, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00906 2A0303, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6DCE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPYEGLYSF YKILTRTKHV TLEGTGSSDL CRCLSTLDLV ALGVGSTLGA 
        60         70         80         90        100
GVYVLAGEVA KVDSGPSIII SFLIAALASV LAGLCYAEFG ARVPLTGSAY 
       110        120        130        140        150
LYSYVTVGEL WAFITGWNLI LSYVIGTSSV ARAWSATFDE LVGKKIGNFL 
       160        170        180        190        200
GNTMHMDLPG LAEYPDIFAV CLIILLAGLL SFGVKESTAV NKVFTAINIL 
       210        220        230        240        250
VLLFVIASGC VTGNLKYWKM SKEDLWATKQ SVSNHSIGNE TGLDFGAGGF 
       260        270        280        290        300
MPFGFSGTLA GAATCFYAFV GFDCIATTGE EVKNPQKSIP LGIVLSLSIC 
       310        320        330        340        350
FFAYFGVSAS LTLMMPYHLL DSQSPLPAAF EYVGWNVAKY IVAVGSLCAL 
       360        370        380        390        400
TTSLLGSMFP MPRILFAMAR DGLLFQPLSR VSSRQSPVIA TIVSGVVAAL 
       410        420        430        440        450
MAFLFNLKAL VDMMSIGTLL AYTLVSTCVL LLRYQPQTDF GKSPDGNLQE 
       460        470        480        490        500
QNISSISHLP ETPSVHSSAL VTRCVIAITL LVCVASVVST VGSQCLLSGR 
       510        520        530        540        550
AWCLSLLVLS LLGIIIALVI IWRQPQNQSK ATFMVPFVPV LPVVSILVNI 
       560        570        580        590        600
YLMVQLSTDT WLRYAVWMAV GFVIYFGYGI RHSIERLHLK ETCTQKMAIS 
       610        620 
STETLCKAQC LELQLGEAKP MD
Length:622
Mass (Da):66,932
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5333925F2334B19
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC078099 mRNA Translation: AAH78099.1

NCBI Reference Sequences

More...RefSeqi		NP_001087158.1, NM_001093689.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		447047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		xla:447047

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078099 mRNA Translation: AAH78099.1
RefSeqiNP_001087158.1, NM_001093689.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PRIDEiQ6DCE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi447047
KEGGixla:447047

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		447047
XenbaseiXB-GENE-5763998 slc7a2.2

Phylogenomic databases

KOiK13864
OrthoDBi439017at2759

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTR2_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DCE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: August 16, 2004
Last modified: May 8, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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