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Protein

Dead end protein homolog 1

Gene

dnd1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during early embryonic survival (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dead end protein homolog 1
Gene namesi
Name:dnd1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815711 – 371Dead end protein homolog 1Add BLAST371

Proteomic databases

PRIDEiQ6DCB7

Expressioni

Developmental stagei

Expressed in germ cells; along the cleavage planes at the vegetal pole of early cleavage stage embryos.

Interactioni

Protein-protein interaction databases

IntActiQ6DCB7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6DCB7
SMRiQ6DCB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 163RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini165 – 245RRM 2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG051370

Family and domain databases

CDDicd12487 RRM1_DND1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034414 DND1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DCB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSAAFLKG DFKRTGKMEL SDEQKSQMWI NSVNSENKEA LLAWVKETGI
60 70 80 90 100
ELVQINGQRK YGGPPPGWIG NAPVSGSEVF IGKIPQDIYE DKLIPLFQSV
110 120 130 140 150
GKLYEFRLMM TFSGLNRGFA YARYISRRQA ISAIMSLNGF EITKGCCIVV
160 170 180 190 200
CRSTEKSELA LDGLPGNFDE NMLKNVLDEV TSGVSSISLH PSPTKESQVL
210 220 230 240 250
AVVKYDSHRA AAMAKKTLCE GSPILPGLPL TVNWLKTDMR QKLRSTDKLQ
260 270 280 290 300
QTKDLSPLPL LYTDRPDLPK ETLLSAVGCL NMLCQEMKLG RPVFLIKLFS
310 320 330 340 350
VTSFGWIRFW YQVVIPTYPT PFCGYAWMIG ENLELNEKYE HARQVVAMKI
360 370
LSALGYIPDF SLGDVTARNA L
Length:371
Mass (Da):41,413
Last modified:March 1, 2005 - v2
Checksum:iB6B0C0C75E8D4741
GO

Sequence cautioni

The sequence AAH78132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270K → R in AAQ63637 (PubMed:12932328).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078132 mRNA Translation: AAH78132.1 Different initiation.
AY321494 mRNA Translation: AAQ63637.1
UniGeneiXl.29785

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078132 mRNA Translation: AAH78132.1 Different initiation.
AY321494 mRNA Translation: AAQ63637.1
UniGeneiXl.29785

3D structure databases

ProteinModelPortaliQ6DCB7
SMRiQ6DCB7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6DCB7, 1 interactor

Proteomic databases

PRIDEiQ6DCB7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051370

Family and domain databases

CDDicd12487 RRM1_DND1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034414 DND1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDND1_XENLA
AccessioniPrimary (citable) accession number: Q6DCB7
Secondary accession number(s): Q6VXX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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