UniProtKB - Q6DC66 (BOKA_DANRE)
Protein
Bcl-2-related ovarian killer protein homolog A
Gene
boka
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.1 Publication
GO - Molecular functioni
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
GO - Biological processi
- extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
- intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
- regulation of apoptotic process Source: InterPro
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2-related ovarian killer protein homolog ACuratedShort name: zBok1 |
Gene namesi | ORF Names:zgc:100979 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040801-131, boka |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial outer membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283818 | 1 – 221 | Bcl-2-related ovarian killer protein homolog AAdd BLAST | 221 |
Proteomic databases
PaxDbi | Q6DC66 |
Expressioni
Tissue specificityi
Strongest expression in ovary and eye, weaker expression in gut, kidney and brain. Little expression in liver or heart.1 Publication
Developmental stagei
Not expressed maternally. Zygotic expression from 24-72 hours post-fertilization (hpf). Also expressed in adult.1 Publication
Interactioni
GO - Molecular functioni
- protein heterodimerization activity Source: GO_Central
- protein homodimerization activity Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000123964 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 44 | BH4Sequence analysisAdd BLAST | 13 | |
Motifi | 64 – 80 | BH3Sequence analysisAdd BLAST | 17 | |
Motifi | 110 – 140 | BH1Sequence analysisAdd BLAST | 31 | |
Motifi | 173 – 187 | BH2Sequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the Bcl-2 family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4728, Eukaryota |
InParanoidi | Q6DC66 |
PhylomeDBi | Q6DC66 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR002475, Bcl2-like IPR036834, Blc2-like_sf IPR026298, Blc2_fam IPR026309, BOK |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF48, PTHR11256:SF48, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit |
SMARTi | View protein in SMART SM00337, BCL, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6DC66-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEMLRRSSVF AAEVMEVFDR SPTDKELVSQ SKVLCRDYIH SRLHRAGIGW
60 70 80 90 100
SKPEHGSGGT LAEVSSVLLW LGDELEYLRP NVYRNVARQL NITIASENIV
110 120 130 140 150
SDAFLAVAAE IFSTEYSRKG LEKHKGVTWG KIVSLYAVAG ALAVDCVRNG
160 170 180 190 200
HPAMVHTIVD CMGEFVRKSL ASWLKKRGGW ADITKCVVST DPSFHSHWLV
210 220
TAACACGHYL KAVVFYLLRE K
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W479 | F8W479_DANRE | Bcl-2-related ovarian killer protei... | boka | 224 | Annotation score: | ||
A0A0R4IZP5 | A0A0R4IZP5_DANRE | Bcl-2-related ovarian killer protei... | boka | 220 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078217 mRNA Translation: AAH78217.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078217 mRNA Translation: AAH78217.1 |
3D structure databases
SMRi | Q6DC66 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000123964 |
Proteomic databases
PaxDbi | Q6DC66 |
Organism-specific databases
ZFINi | ZDB-GENE-040801-131, boka |
Phylogenomic databases
eggNOGi | KOG4728, Eukaryota |
InParanoidi | Q6DC66 |
PhylomeDBi | Q6DC66 |
Miscellaneous databases
ChiTaRSi | boka, zebrafish |
PROi | PR:Q6DC66 |
Family and domain databases
CDDi | cd06845, Bcl-2_like, 1 hit |
Gene3Di | 1.10.437.10, 1 hit |
InterProi | View protein in InterPro IPR002475, Bcl2-like IPR036834, Blc2-like_sf IPR026298, Blc2_fam IPR026309, BOK |
PANTHERi | PTHR11256, PTHR11256, 1 hit PTHR11256:SF48, PTHR11256:SF48, 1 hit |
Pfami | View protein in Pfam PF00452, Bcl-2, 1 hit |
SMARTi | View protein in SMART SM00337, BCL, 1 hit |
SUPFAMi | SSF56854, SSF56854, 1 hit |
PROSITEi | View protein in PROSITE PS50062, BCL2_FAMILY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BOKA_DANRE | |
Accessioni | Q6DC66Primary (citable) accession number: Q6DC66 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families