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UniProtKB - Q6DBY0 (NUP85_DANRE)

Entry version 74 (02 Dec 2020)
Sequence version 1 (16 Aug 2004)
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Protein

Nuclear pore complex protein Nup85

Gene

nup85

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-2467813, Separation of Sister Chromatids
R-DRE-2500257, Resolution of Sister Chromatid Cohesion
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-5663220, RHO GTPases Activate Formins
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation
R-DRE-9648025, EML4 and NUDC in mitotic spindle formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup85
Alternative name(s):
85 kDa nucleoporin
Nucleoporin Nup85
Pericentrin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup85
Synonyms:pcnt1
ORF Names:zgc:100943
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-040801-145, nup85

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241921 – 649Nuclear pore complex protein Nup85Add BLAST649

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6DBY0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nuclear pore complex (NPC).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000067719

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6DBY0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin Nup85 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2271, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6DBY0

Database of Orthologous Groups

More...OrthoDBi		588551at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6DBY0

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011502, Nucleoporin_Nup85

The PANTHER Classification System

More...PANTHERi		PTHR13373, PTHR13373, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07575, Nucleopor_Nup85, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6DBY0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELDVEPST TLVPAAGVLQ KHLGFEWGPG DLLVYETNYK LRGSSSAGSP 
        60         70         80         90        100
LVHVVRKDED ICSPILRKLF NESHLIFMGL QKIKEDAPSK NKKTQFVSIS 
       110        120        130        140        150
RNYRSVIRAC MEELQQNAVT AQDGSLASQY GDQVSILLAI ELIWNLCEVL 
       160        170        180        190        200
FIEAAPAGSL LLHLLNWVRL HKSDVDTRAR EVLQSENPTQ HPAYWDVVTS 
       210        220        230        240        250
LVLQGRMDEA RQILSKQASL RMESSSVFKR MDTLLQTMPI FNPAGAQTLT 
       260        270        280        290        300
EFDVKWRHWH EECDRCLQDH TFASSAELET LCKILLGDED VILEQKDLMS 
       310        320        330        340        350
TWYHFLVSRL LFTHPTIKPP DLHYYAQSSM NMFLGPRATP EPLDIILLSA 
       360        370        380        390        400
FEFDLHQVIK DCSIALNNWW FVAHLTDLLD HCKLLQSHNL HFGSNLREFL 
       410        420        430        440        450
VLEYASGLFT HHSLWQLAVD YLDHCPEFGR VYLELQIERV PLDTERKANK 
       460        470        480        490        500
VLRICEDRQM SEQVRSICKI MAKRALRNNR LGSALSWSIR AKDAALATLI 
       510        520        530        540        550
SERFLQDYSN KGSFTDLDVL DNLGPAMLLS DRLTFLGKYR EFHRLYGENR 
       560        570        580        590        600
FSDAAKLLLS LMMAKIAPRS LWMTLLTDAL PLLEQEEVIF TVDQTYELMS 
       610        620        630        640 
CLEELNSGTK DSNQMEQEED LESTKTELLR VALARNLATA IVKEGTIET
Length:649
Mass (Da):74,148
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F2ABF964724E588
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IZD5A0A0R4IZD5_DANRE
Nuclear pore complex protein Nup85
nup85
327Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IBW5A0A0R4IBW5_DANRE
Nuclear pore complex protein Nup85
nup85
412Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC078318 mRNA Translation: AAH78318.1

NCBI Reference Sequences

More...RefSeqi		NP_001003625.1, NM_001003625.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		445231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:445231

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078318 mRNA Translation: AAH78318.1
RefSeqiNP_001003625.1, NM_001003625.1

3D structure databases

SMRiQ6DBY0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067719

Proteomic databases

PaxDbiQ6DBY0

Genome annotation databases

GeneIDi445231
KEGGidre:445231

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79902
ZFINiZDB-GENE-040801-145, nup85

Phylogenomic databases

eggNOGiKOG2271, Eukaryota
InParanoidiQ6DBY0
OrthoDBi588551at2759
PhylomeDBiQ6DBY0

Enzyme and pathway databases

ReactomeiR-DRE-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-2467813, Separation of Sister Chromatids
R-DRE-2500257, Resolution of Sister Chromatid Cohesion
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-5663220, RHO GTPases Activate Formins
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation
R-DRE-9648025, EML4 and NUDC in mitotic spindle formation

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q6DBY0

Family and domain databases

InterProiView protein in InterPro
IPR011502, Nucleoporin_Nup85
PANTHERiPTHR13373, PTHR13373, 1 hit
PfamiView protein in Pfam
PF07575, Nucleopor_Nup85, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP85_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6DBY0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 16, 2004
Last modified: December 2, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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