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UniProtKB - Q6CXY0 (ALG13_KLULA)
Protein
UDP-N-acetylglucosamine transferase subunit ALG13
Gene
ALG13
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Functioni
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity).
By similarityCatalytic activityi
- N-acetyl-α-D-glucosaminyl-diphosphodolichol + UDP-N-acetyl-α-D-glucosamine = H+ + N,N'-diacetylchitobiosyl diphosphodolichol + UDPEC:2.4.1.141
GO - Molecular functioni
- identical protein binding Source: EnsemblFungi
- N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- dolichol-linked oligosaccharide biosynthetic process Source: EnsemblFungi
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylglucosamine transferase subunit ALG13 (EC:2.4.1.141)Alternative name(s): Asparagine-linked glycosylation protein 13 |
Gene namesi | Name:ALG13 Ordered Locus Names:KLLA0A04774g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Cytosol
- cytosol Source: EnsemblFungi
Endoplasmic reticulum
- extrinsic component of endoplasmic reticulum membrane Source: EnsemblFungi
- UDP-N-acetylglucosamine transferase complex Source: EnsemblFungi
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215602 | 1 – 197 | UDP-N-acetylglucosamine transferase subunit ALG13Add BLAST | 197 |
Interactioni
Subunit structurei
Heterodimer with ALG14 to form a functional enzyme.
By similarityGO - Molecular functioni
- identical protein binding Source: EnsemblFungi
Protein-protein interaction databases
STRINGi | 28985.XP_451209.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 28 family.Curated
Phylogenomic databases
eggNOGi | KOG3349, Eukaryota |
HOGENOMi | CLU_085408_2_0_1 |
InParanoidi | Q6CXY0 |
OMAi | ENKTRWP |
Family and domain databases
InterProi | View protein in InterPro IPR039042, Alg13-like IPR007235, Glyco_trans_28_C |
PANTHERi | PTHR12867, PTHR12867, 1 hit |
Pfami | View protein in Pfam PF04101, Glyco_tran_28_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6CXY0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNTVLVTCG ATVSFPRLVE TVLDRSVTEK LKVLGYGRIV IQYGRGFSDT
60 70 80 90 100
FLQLVEKHLG LFTEKKSCGI KVLDKIENLK VISVDGIEIC GFEFSHDIEK
110 120 130 140 150
LIANNIDLVI SHAGTGSILD SLRVGKKLIV VVNDTLMDNH QQLIADKFEQ
160 170 180 190
QKLLWSVHAN TEELLRALDR SENEELLKID NTYNKQFEKL LYNVAID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382121 Genomic DNA Translation: CAH02797.1 |
RefSeqi | XP_451209.1, XM_451209.1 |
Genome annotation databases
EnsemblFungii | CAH02797; CAH02797; KLLA0_A04774g |
GeneIDi | 2896531 |
KEGGi | kla:KLLA0_A04774g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382121 Genomic DNA Translation: CAH02797.1 |
RefSeqi | XP_451209.1, XM_451209.1 |
3D structure databases
AlphaFoldDBi | Q6CXY0 |
SMRi | Q6CXY0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28985.XP_451209.1 |
Genome annotation databases
EnsemblFungii | CAH02797; CAH02797; KLLA0_A04774g |
GeneIDi | 2896531 |
KEGGi | kla:KLLA0_A04774g |
Phylogenomic databases
eggNOGi | KOG3349, Eukaryota |
HOGENOMi | CLU_085408_2_0_1 |
InParanoidi | Q6CXY0 |
OMAi | ENKTRWP |
Family and domain databases
InterProi | View protein in InterPro IPR039042, Alg13-like IPR007235, Glyco_trans_28_C |
PANTHERi | PTHR12867, PTHR12867, 1 hit |
Pfami | View protein in Pfam PF04101, Glyco_tran_28_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG13_KLULA | |
Accessioni | Q6CXY0Primary (citable) accession number: Q6CXY0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families