UniProtKB - Q6CW24 (CCPR_KLULA)
Protein
Cytochrome c peroxidase, mitochondrial
Gene
CCP1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Functioni
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity
Catalytic activityi
- EC:1.11.1.5
Cofactori
heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 101 | Transition state stabilizerPROSITE-ProRule annotation | 1 | |
Active sitei | 105 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 228 | Iron (heme axial ligand) | 1 | |
Active sitei | 244 | Tryptophan radical intermediateBy similarity | 1 |
GO - Molecular functioni
- cytochrome-c peroxidase activity Source: UniProtKB-EC
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to oxidative stress Source: EnsemblFungi
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Ligand | Heme, Iron, Metal-binding |
Protein family/group databases
PeroxiBasei | 2358, KlCcP01 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CCP1 Ordered Locus Names:KLLA0B07557g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion matrix By similarity
Mitochondrion
- mitochondrial intermembrane space Source: EnsemblFungi
- mitochondrial matrix Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 12 | MitochondrionAdd BLAST | 12 | |
ChainiPRO_0000045294 | 13 – 346 | Cytochrome c peroxidase, mitochondrialAdd BLAST | 334 |
Interactioni
Subunit structurei
Forms a one-to-one complex with cytochrome c.
By similarityProtein-protein interaction databases
STRINGi | 28985.XP_451865.1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QR1E, Eukaryota |
HOGENOMi | CLU_036959_1_1_1 |
InParanoidi | Q6CW24 |
OMAi | CAIQEMQ |
Family and domain databases
InterProi | View protein in InterPro IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR002207, Peroxidase_I IPR019794, Peroxidases_AS |
Pfami | View protein in Pfam PF00141, peroxidase, 1 hit |
PRINTSi | PR00459, ASPEROXIDASE PR00458, PEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS00436, PEROXIDASE_2, 1 hit PS50873, PEROXIDASE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6CW24-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTTFGNVFR RVNVKTLSFI VGAGALAGSA TGTVMEYQDM RNYNNRNYNK
60 70 80 90 100
QKLAALAAAH VAAKEKYDVA KYQKVYNDIA LKIRDEDEYD DFIGYGPVLV
110 120 130 140 150
RLAWHCAGTW DAKDNTGGPY GGTYRFAMET NDPSNNGLQN AAKFLEPIHE
160 170 180 190 200
KYPWLSHGDL YSLAGVTAIQ EMQGPTIPWR SGRVDQPEDT TPENGRLPDA
210 220 230 240 250
SKDAKYVRCF FHRLNFEDRQ VVALLGAHAL GKTHLKNSGF EGPWGAATNI
260 270 280 290 300
FTNEFYNNLL NEKWDLITND AGNKQYVNDK GWMMLPTDMA LVQDPKYLPI
310 320 330 340
VKEFANDQDT FFKEFTKAFV VLLENGIDFP QENKPIKFKT LDAQDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382122 Genomic DNA Translation: CAH02258.1 |
RefSeqi | XP_451865.1, XM_451865.1 |
Genome annotation databases
EnsemblFungii | CAH02258; CAH02258; KLLA0_B07557g |
GeneIDi | 2896897 |
KEGGi | kla:KLLA0_B07557g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382122 Genomic DNA Translation: CAH02258.1 |
RefSeqi | XP_451865.1, XM_451865.1 |
3D structure databases
SMRi | Q6CW24 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 28985.XP_451865.1 |
Protein family/group databases
PeroxiBasei | 2358, KlCcP01 |
Genome annotation databases
EnsemblFungii | CAH02258; CAH02258; KLLA0_B07557g |
GeneIDi | 2896897 |
KEGGi | kla:KLLA0_B07557g |
Phylogenomic databases
eggNOGi | ENOG502QR1E, Eukaryota |
HOGENOMi | CLU_036959_1_1_1 |
InParanoidi | Q6CW24 |
OMAi | CAIQEMQ |
Family and domain databases
InterProi | View protein in InterPro IPR002016, Haem_peroxidase IPR010255, Haem_peroxidase_sf IPR002207, Peroxidase_I IPR019794, Peroxidases_AS |
Pfami | View protein in Pfam PF00141, peroxidase, 1 hit |
PRINTSi | PR00459, ASPEROXIDASE PR00458, PEROXIDASE |
SUPFAMi | SSF48113, SSF48113, 1 hit |
PROSITEi | View protein in PROSITE PS00436, PEROXIDASE_2, 1 hit PS50873, PEROXIDASE_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCPR_KLULA | |
Accessioni | Q6CW24Primary (citable) accession number: Q6CW24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families