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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi565Zinc; catalyticPROSITE-ProRule annotation1
Active sitei566PROSITE-ProRule annotation1
Metal bindingi569Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi572Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:KLLA0B12397g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000033858428 – 779Mitochondrial intermediate peptidaseAdd BLAST752

Proteomic databases

PRIDEiQ6CVF7

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_452082.1

Structurei

3D structure databases

ProteinModelPortaliQ6CVF7
SMRiQ6CVF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
HOGENOMiHOG000076521
InParanoidiQ6CVF7
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CVF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTVSVGRQ YVQRYFGHCL IVNSVRHSSS ATVNRLKQPL RRVFDDDSHW
60 70 80 90 100
RALNHSNYKL NESKGRKFGL RSTSDLETGL FQNSYLKSAN GLVEFTQHSF
110 120 130 140 150
EKAKELVQKI HSIETQDEMK YYIKDLDQLS DVLCRVIDLC EFIRATHPDK
160 170 180 190 200
KFVQTAQQCH EKMFEIMNIL NTDVRLCDLL TQCLRESDVL GLDSEEIRTG
210 220 230 240 250
KILLEDFEKS GIYMKPEIRE KFIQLSQEIS VIGQDFINNT EYVRSNYIKI
260 270 280 290 300
SCELMDAHVN KMVCSQMKKD ITGEYYKVPT YGYIPHTLLR TCSDEVIRMK
310 320 330 340 350
IWTEMHSCSD AQIERLTKLI SLRVELAKLL GSQNFAQYQL HGKMAKTPEN
360 370 380 390 400
VSGFLESLVH STRIKAASEL KPLAVLKSEL TGTQTPHTSE EVLELMKPWD
410 420 430 440 450
RDYYGSIQAL AQRRSSSLDN GESISSSFSL GVVMQGLSDL FEKIYGIKLV
460 470 480 490 500
PATPKTGETW SPDVRRIDVV DEHDGLIGVM YCDLFEREGK TPNPAHFTVC
510 520 530 540 550
CSRNMYLNEA DTSTIQVGVN SNGQKFQLPV ISLVCDFRWV EVNMGDGKHQ
560 570 580 590 600
QMCLLQLNEI ETLFHEMGHA MHSMLGRTQL QNVSGTRCAT DFVELPSILM
610 620 630 640 650
EHFARDTRVL SSISSHYKTG KSLDVEVLKN HQLENQFLQN CETFSQIKMS
660 670 680 690 700
FLDQELHNLD HTTDGSIDVI AIYHRLERRL AVLPDDQSNW CGKFGHLFGY
710 720 730 740 750
GASYYSYLFD RAIASKIWDH LFEQDPFNRT NGTKFKEGLL QWGGSRDPWY
760 770
LLSQVLDEPR LAKGDEWGMR YIGDVKTGM
Length:779
Mass (Da):89,380
Last modified:August 16, 2004 - v1
Checksum:iE25823250E5683BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382122 Genomic DNA Translation: CAH02475.1
RefSeqiXP_452082.1, XM_452082.1

Genome annotation databases

EnsemblFungiiCAH02475; CAH02475; KLLA0_B12397g
GeneIDi2897324
KEGGikla:KLLA0B12397g

Similar proteinsi

Entry informationi

Entry nameiPMIP_KLULA
AccessioniPrimary (citable) accession number: Q6CVF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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