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Protein

Palmitoyltransferase PFA4

Gene

PFA4

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.UniRule annotation

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108S-palmitoyl cysteine intermediateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA4UniRule annotation (EC:2.3.1.225UniRule annotation)
Alternative name(s):
Protein S-acyltransferaseUniRule annotation
Short name:
PATUniRule annotation
Protein fatty acyltransferase 4UniRule annotation
Gene namesi
Name:PFA4UniRule annotation
Ordered Locus Names:KLLA0C06204g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicUniRule annotation9
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Topological domaini31 – 122LumenalUniRule annotationAdd BLAST92
Transmembranei123 – 143HelicalUniRule annotationAdd BLAST21
Topological domaini144 – 163CytoplasmicUniRule annotationAdd BLAST20
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Topological domaini185 – 377LumenalUniRule annotationAdd BLAST193

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129681 – 377Palmitoyltransferase PFA4Add BLAST377

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_452474.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 128DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1314 Eukaryota
COG5273 LUCA
HOGENOMiHOG000248636
InParanoidiQ6CUB5
KOiK18932
OMAiLPWPPDG
OrthoDBiEOG092C4CK8

Family and domain databases

HAMAPiMF_03199 DHHC_PAT_PFA4, 1 hit
InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR033682 PFA4
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CUB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIKLKNRWL GVAIPAFLVA LIGYGSHYFI LSNFLSWNEQ IFYQTCQTMI
60 70 80 90 100
WVSYYLAIYT NPGIPPKDFK PSAEEWHNYC KKCRVYKPER AHHCKTCNQC
110 120 130 140 150
VLAMDHHCPW TLNCVGHSNF PHFMRFLFWV IFSTAYLLFL LIGRIYLLWS
160 170 180 190 200
IRHTAFHHRS TSEIIFICIM TPMDAFVLLT VSSLLGRCIY NQCLHGMTQI
210 220 230 240 250
ESWEMDRIQS LHYKNRLLAQ VIDRLVERRP EILPAKQHEI NKLLSKRYVN
260 270 280 290 300
QEDFTNFPYD VNPWTNINNA MGPWYLWLWP WSKPPTIGTS FAKNELFFYD
310 320 330 340 350
PNSSIEDMLM SLPWPPDGLT HHSRALGSGS SIETIVSGGE QVIRDKSVDL
360 370
RDRLGRNSWY NDWGEDLSDF GVDTELE
Length:377
Mass (Da):44,192
Last modified:August 16, 2004 - v1
Checksum:iB241E3F452A651D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA Translation: CAH01325.1
RefSeqiXP_452474.1, XM_452474.1

Genome annotation databases

EnsemblFungiiCAH01325; CAH01325; KLLA0_C06204g
GeneIDi2892046
KEGGikla:KLLA0C06204g

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA Translation: CAH01325.1
RefSeqiXP_452474.1, XM_452474.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_452474.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH01325; CAH01325; KLLA0_C06204g
GeneIDi2892046
KEGGikla:KLLA0C06204g

Phylogenomic databases

eggNOGiKOG1314 Eukaryota
COG5273 LUCA
HOGENOMiHOG000248636
InParanoidiQ6CUB5
KOiK18932
OMAiLPWPPDG
OrthoDBiEOG092C4CK8

Family and domain databases

HAMAPiMF_03199 DHHC_PAT_PFA4, 1 hit
InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR033682 PFA4
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFA4_KLULA
AccessioniPrimary (citable) accession number: Q6CUB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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