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Protein

Purine nucleoside phosphorylase

Gene

KLLA0_C16621g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42PhosphateUniRule annotation1
Binding sitei76PhosphateUniRule annotation1
Binding sitei129Phosphate; via amide nitrogenUniRule annotation1
Binding sitei214Purine nucleosideUniRule annotation1
Binding sitei233PhosphateUniRule annotation1
Binding sitei256Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
ORF Names:KLLA0_C16621gImported
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome C

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_452943.1

Structurei

3D structure databases

ProteinModelPortaliQ6CSZ6
SMRiQ6CSZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 303PNP_UDP_1InterPro annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni96 – 98Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
HOGENOMiHOG000045183
InParanoidiQ6CSZ6
KOiK03783
OMAiVLISDHI
OrthoDBiEOG092C4NS7

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CSZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLDINEQR ALIKSAHRYI SEKLEDHFSS EFLPKALVIC GSGLSGISTK
60 70 80 90 100
IADEPKPLIL SYSTIPGFKV STVPGHSGEL IFGYMNGAPV VLMNGRLHSY
110 120 130 140 150
EGHSLAETVH PIRALHLLGS INVLIVTNAA GGINASFKAG DLMCVYDHIN
160 170 180 190 200
FPGLCGFHPL RGANFDEFGP RFLATSDAYD LELRKLLFSK KKELNIERKI
210 220 230 240 250
HEGTYSYVHG PTFESRAESR FLRLAGTDAV GMSTVPEVVT ARHCGWRVLA
260 270 280 290 300
LSLITNECVV DPPASAHDEN PVPIQEGKAT HEEVLENSAK ASKDVQELIF

SVVAEI
Length:306
Mass (Da):33,366
Last modified:August 16, 2004 - v1
Checksum:i057EC84401DED3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA Translation: CAH01794.1
RefSeqiXP_452943.1, XM_452943.1

Genome annotation databases

EnsemblFungiiCAH01794; CAH01794; KLLA0_C16621g
GeneIDi2891987
KEGGikla:KLLA0_C16621g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382123 Genomic DNA Translation: CAH01794.1
RefSeqiXP_452943.1, XM_452943.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IFKX-ray1.97A/B/C1-306[»]
ProteinModelPortaliQ6CSZ6
SMRiQ6CSZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_452943.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH01794; CAH01794; KLLA0_C16621g
GeneIDi2891987
KEGGikla:KLLA0_C16621g

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
HOGENOMiHOG000045183
InParanoidiQ6CSZ6
KOiK03783
OMAiVLISDHI
OrthoDBiEOG092C4NS7

Enzyme and pathway databases

UniPathwayi
UPA00606

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6CSZ6_KLULA
AccessioniPrimary (citable) accession number: Q6CSZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 10, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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