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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

HIS6

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (HIS1)
  2. Histidine biosynthesis trifunctional protein (HIS4)
  3. Histidine biosynthesis trifunctional protein (HIS4)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (HIS6)
  5. Imidazole glycerol phosphate synthase hisHF (KLLA0_F06578g)
  6. Imidazoleglycerol-phosphate dehydratase (HIS3)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. Histidine biosynthesis trifunctional protein (HIS4)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00009

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:HIS6
Ordered Locus Names:KLLA0D16148g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome D

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001419591 – 2671-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseAdd BLAST267

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_453772.1

Structurei

3D structure databases

ProteinModelPortaliQ6CQL7
SMRiQ6CQL7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

eggNOGiKOG3055 Eukaryota
COG0106 LUCA
HOGENOMiHOG000172261
InParanoidiQ6CQL7
KOiK01814
OMAiFVAMNKW
OrthoDBiEOG092C43NB

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR011858 HisA_euk
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02129 hisA_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CQL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKFVGCIDL HDGQVKQIVG GTLTDSSKDK VTTNFVSKLP PSHYAKLYHE
60 70 80 90 100
NQVEGCHVIK LGPNNDEAAL EALNECPNFL QVGGGITLDN CGYWLKYASK
110 120 130 140 150
IIVTSFLFDK STYQFQREKL VKLAEICGKD RLVVDLSCKR VTKPDQEPKW
160 170 180 190 200
VVAMNKWQTL TDLELNERTF ADLCQYTDEF LVHAADVEGL CNGIDEELVA
210 220 230 240 250
HLYKWTADIP KVKIVYAGGA KSVDDLRLVE KLSHGKIDLT FGSALDIFGG
260
SLVKFEDCVQ WNHEKHA
Length:267
Mass (Da):29,913
Last modified:August 16, 2004 - v1
Checksum:i6A75F855853C6FA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA Translation: CAH00868.1
RefSeqiXP_453772.1, XM_453772.1

Genome annotation databases

EnsemblFungiiCAH00868; CAH00868; KLLA0_D16148g
GeneIDi2893434
KEGGikla:KLLA0_D16148g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA Translation: CAH00868.1
RefSeqiXP_453772.1, XM_453772.1

3D structure databases

ProteinModelPortaliQ6CQL7
SMRiQ6CQL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_453772.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAH00868; CAH00868; KLLA0_D16148g
GeneIDi2893434
KEGGikla:KLLA0_D16148g

Phylogenomic databases

eggNOGiKOG3055 Eukaryota
COG0106 LUCA
HOGENOMiHOG000172261
InParanoidiQ6CQL7
KOiK01814
OMAiFVAMNKW
OrthoDBiEOG092C43NB

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00009

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR011858 HisA_euk
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02129 hisA_euk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIS4_KLULA
AccessioniPrimary (citable) accession number: Q6CQL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: August 16, 2004
Last modified: October 10, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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