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Protein

Mitochondrial glycine transporter

Gene

KLLA0E08911g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Ordered Locus Names:KLLA0E08911g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 36Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei59 – 85Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei108 – 133Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei161 – 184Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei212 – 238Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei267 – 285Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789361 – 294Mitochondrial glycine transporterAdd BLAST294

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_454351.1

Structurei

3D structure databases

ProteinModelPortaliQ6CNY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 84Solcar 1UniRule annotationAdd BLAST80
Repeati102 – 186Solcar 2UniRule annotationAdd BLAST85
Repeati208 – 292Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
HOGENOMiHOG000006978
InParanoidiQ6CNY8
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 1 hit
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6CNY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQRRATTH LIGGFSGGLV SAIILQPFDL LKTRLQQDKT STLWKTLKSI
60 70 80 90 100
ETPSQLWRGA LPSCIRTSVG SAMYLTMLNS IRQAISKGKN TGSTGSSYLP
110 120 130 140 150
QLNMYENMFS GAVTRALTGL ITMPITVIKV RYESTLYQYT SLRYATSHIF
160 170 180 190 200
RTEGLRGFFR GFGATALRDA PYAGLYMLFY DRMKVLVPTL LPSNVVKLNS
210 220 230 240 250
DNRYSTYAST LINGSSAFSA AVIATSITAP FDTVKTRMQL EPAKFHSFTS
260 270 280 290
TFWHIATKES VRNLFAGISL RLTRKAFSAG IAWGIYEEIV KKFV
Length:294
Mass (Da):32,692
Last modified:August 16, 2004 - v1
Checksum:iB2BFF0ECAD4FF2B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA Translation: CAG99438.1
RefSeqiXP_454351.1, XM_454351.1

Genome annotation databases

EnsemblFungiiCAG99438; CAG99438; KLLA0_E08911g
GeneIDi2894220
KEGGikla:KLLA0E08911g

Similar proteinsi

Entry informationi

Entry nameiS2538_KLULA
AccessioniPrimary (citable) accession number: Q6CNY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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