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Entry version 84 (31 Jul 2019)
Sequence version 1 (16 Aug 2004)
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Protein
Submitted name:

KLLA0E17887p

Gene

KLLA0_E17887g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KLLA0E17887pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:KLLA0_E17887gImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284590 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000598 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome E

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
28985.XP_454757.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1508 – 1697Ras-GAPInterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni452 – 488DisorderedSequence analysisAdd BLAST37
Regioni728 – 755DisorderedSequence analysisAdd BLAST28
Regioni774 – 802DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi471 – 488PolarSequence analysisAdd BLAST18
Compositional biasi778 – 802PolarSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1826 Eukaryota
ENOG410XRPJ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113101

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6CMT2

Identification of Orthologs from Complete Genome Data

More...
OMAi
RLYNIVF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.525.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036865 CRAL-TRIO_dom_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot

The PANTHER Classification System

More...
PANTHERi
PTHR10194 PTHR10194, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00616 RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00323 RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6CMT2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEAHNVLTD VTAFLLSQLD PLLPVNSHVK TFEEVERDPY FTNIRLSLFN
60 70 80 90 100
LVVSHGYSAI SPAIVAKLEQ IANLSKDKNQ DFDILLTLVV LLRMFTDTSE
110 120 130 140 150
IYWRNLDPEY KLNYSLSDDS AFSRFYNGYS VQMASLHTIR PKPLSPQIAN
160 170 180 190 200
SFLQLLSRIK SNKRVIKMLN SMLKSLHGGS SSSLYPSQGK DNSNSDAKKS
210 220 230 240 250
KYYTYLVDVL DQHCAYLFKY IAASNPHEFH SFIRSVIITP LLVAHTHTES
260 270 280 290 300
EIAPYLCYFS FHYITSETLP SFLDVLQRMV VRMKKSIHQE ILLYFASESI
310 320 330 340 350
QSWIMARPHD YLRVIEGLQK NSSDPALQNI QKISTSLFED VFSSFNIERI
360 370 380 390 400
LTEGAISSAT SPTVISPQEL SSHLDPFEEY AIYDEESSSG HSRTASTSSG
410 420 430 440 450
RSGYNAPYYG PQFELNDDTE DMTRVSVLTF ATLMLMLSPD IFEEINNTSL
460 470 480 490 500
KNIPDDALGT DEDTDAFDDK SSSDSPFLSR SSSSTLKSSR SSKFGLKKIR
510 520 530 540 550
NQLTSLNHVT NKKTKFLLTI LKNINGNNII SEYSILDTLR VLILISKLST
560 570 580 590 600
SPLLREADSS VSYFTRRLFF LMCDLLQLGS EKDAKRNPMV AHCLAKFPQS
610 620 630 640 650
HFKLQVDYFY VACSLDADAF LEKLSDFIKR KHSGISHIRM ITDGFCIYFN
660 670 680 690 700
NATMHNTKDR IMTRIDDFLK DTACEMANIL LSESNLFDEH ASEVVDSIFE
710 720 730 740 750
LKPGDYSKGY QKIQFNASPL PSSSPAFMNF FSRTGDSTPT SKSTSTTSSS
760 770 780 790 800
SLSPVEGVSA AIAGKNLRDI VAPTARRPSK SSFASLRETS SPNEGEKSTN
810 820 830 840 850
TIRTIIDKNI KSPLRVGSML RKTSQESISS ATVKNIRDTL ERHEQETTQS
860 870 880 890 900
ARIILINIFS IYKGMTRYYY MTYDEDSDTT VYLRDFNRTI KPVFASLVDD
910 920 930 940 950
NESLFDTARG IISSVITQLK EPQVDITAFR SVCYVGSAYL LSLMGTTLFD
960 970 980 990 1000
LNLSDLKREQ LLKPLVDLWT ARIGIAKTYE MNDSLSDLLE EEALTFHLIR
1010 1020 1030 1040 1050
GSVGRALFCS LYSNNTAIHK LLKTAFKLFT EEIRIHQLLH EDDVDDIDDD
1060 1070 1080 1090 1100
HELDFANVEF FQVMCRDNYV STGVVAFQRR LRTDILKYIK FPDKIVFDVS
1110 1120 1130 1140 1150
HLIYKRWYDA SLKPSLSTSE TSHFRNYAGF LAASCGIFST INDSTQHHFP
1160 1170 1180 1190 1200
LLHEMKKSVE AKVSYFVGKQ CSWLNNEDLL TRENSKDILA TELHPLAFDA
1210 1220 1230 1240 1250
LFAALRQRID ELKDINIVEK DNELSFILLE QVIMVVRMIL ERDDTSEVLI
1260 1270 1280 1290 1300
IVSLPLLNLI DDILRIVDTI DKSSPKYFKC VIHLSKMLKS FQHSESSICI
1310 1320 1330 1340 1350
AGYMVVKNRW LRLVTQWFQS AIFKEFDLLN LSKSHRDMDL EKRDMDYLYI
1360 1370 1380 1390 1400
DTTIESSKAI AYLTKDLVLE APQSMSEIEL QRSKSVVFGN YFNILLKALE
1410 1420 1430 1440 1450
KSTNVENFPS TLRHKIASLN ENIIISLTNL LIANVDVGLN HATPIGYSNN
1460 1470 1480 1490 1500
RNIRLAFMNV FVNIVSSFDI SNNRTKRKRD EIVEEVVLMT LKRPTLLSKA
1510 1520 1530 1540 1550
CRICPASDID ALASSIVYFF DVKNAAHIIV TELVREEIGN ATRHMEILRR
1560 1570 1580 1590 1600
NSCATRALSM LARLKGMDYL SNILKPILEE LINSKECFDV EKLDPNDVDA
1610 1620 1630 1640 1650
PRNLMLFKKY MTKVVDAITG SVDSFPPQFF VICQAIHSSA SERFPEYADI
1660 1670 1680 1690 1700
AVGSFLFLRF FCPALVSPDS EEIVDSLTPK ARKSSMSLAK VIQNIANGSV
1710 1720 1730 1740 1750
NSIKWKILES ESEFLKNCSN KIFEFLSVVS DKNRKVKINL RMQNRVLPNE
1760 1770 1780 1790 1800
FSFLHKFLYY HGLEMRNALI EDIKSFDDLA TVRETAEAVD ELLSLMGQPR
1810 1820 1830 1840 1850
MEFKNEIPAY IREHSETSSE LYEFMIKQAV KCPETPENEC KFVQESVTSE
1860 1870 1880 1890 1900
GLPVVIFNWC EYQKDGNDDV ETLIYLIFQI YSKVMTKKHF FVTDCTGFDG
1910 1920 1930 1940 1950
VRQPKNRFVK LSSLFFNLIP AEGLANCETF YFFNPTPIYL EWWTEFQNSH
1960 1970 1980 1990 2000
ANIFQNMNVS MSFLNTDSDP KLIKALGLSD YSKEVYHDVR VTLHDVSLYD
2010 2020 2030 2040 2050
EAKRQFSPVT LKVGNKYFQI VHDSAWTLKA SDASDTIVIN PNDVYEIAEV
2060 2070 2080 2090 2100
ASTSVSRITG VSSEFCFELR NRKRLIMSSP KYLEILKMFY YSQAKILEEF
2110 2120 2130 2140 2150
NDNEYSDISS RHSKEAIKTA DIVSHLLLVA LVGLGGDDEI RVVSYNLLSS
2160 2170 2180 2190 2200
MHTTFSLNMG HLLPKTPDIY ISEDPNPIFE PLIKTLAETS PELTSYYLKY
2210 2220 2230 2240 2250
SIDLLENGEH DLHFIANLLR TMRYWAKNLS KHVFLADDQK GPEIATKLVR
2260 2270 2280 2290 2300
RLVKLTVQQN QPTSLYLDYI WPVLVHDSCL LKEVIEEVVG HCMDRAAEGV
2310 2320 2330 2340 2350
DWHPACKILL RAPTIDITGV IIKRVIDITH SFLPNLKEET NVNSWTELII
2360 2370 2380 2390 2400
LVHLCSSLFC DSPLLVDIYM PEVLYIVSLL IDVGSTEMRL SLHKLLMNAC
2410 2420 2430 2440 2450
QSLLSNASLP KYNRRNLYEI QKIFSDQKMK IMFGFSQERG RVLQNFSASS
2460 2470 2480 2490 2500
FLTKFTTLEH FVNNLMSLMD NGSLINVEQW KTRYMQYIMG TVFHVQSFLS
2510 2520 2530 2540 2550
ARAMMILGIV SKEGISDGLL LNLLRQSMVI VAMPDVNDEQ IFFVISTFFT
2560 2570 2580 2590 2600
YTKAVIGVDP QSPLLPKLFW LASSISFSIN MMIYQSGLLF MSSTAQHLSL
2610 2620 2630 2640 2650
GSMEKMDRGE IPEPLIKQLM AQRNFGENIL RQVEAMGDLR VTESNFSHVM
2660 2670 2680 2690 2700
ISLICKGLLI PYTRATSLSS LVVFFKLFYF ELMFGPNEDY LIFMFFIFIL
2710 2720 2730 2740 2750
QRPSAFLKCM EDVDMDTDVV QLDDRNKIHK SLLDWLVKFS PDACLTMYKA
2760 2770 2780 2790 2800
SLYFSCKATD EQGKVRFMLV YRHLMQHNLK AAFKLYPFVL NELRRLSKYS
2810 2820 2830 2840 2850
NNSSTVLLSF EIIKMAVKSK EYLKLPMIEK EMYKKLEERG LTGIKSIPFE
2860 2870 2880
NELANDVLTG VRENPIITYE RKKLAVMLLS KVISSASER
Length:2,889
Mass (Da):329,662
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54A5A1F32A94A04D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR382125 Genomic DNA Translation: CAG99844.1

NCBI Reference Sequences

More...
RefSeqi
XP_454757.1, XM_454757.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG99844; CAG99844; KLLA0_E17887g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2893923

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
kla:KLLA0_E17887g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA Translation: CAG99844.1
RefSeqiXP_454757.1, XM_454757.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi28985.XP_454757.1

Genome annotation databases

EnsemblFungiiCAG99844; CAG99844; KLLA0_E17887g
GeneIDi2893923
KEGGikla:KLLA0_E17887g

Phylogenomic databases

eggNOGiKOG1826 Eukaryota
ENOG410XRPJ LUCA
HOGENOMiHOG000113101
InParanoidiQ6CMT2
OMAiRLYNIVF

Family and domain databases

Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR036865 CRAL-TRIO_dom_sf
IPR039360 Ras_GTPase
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
PANTHERiPTHR10194 PTHR10194, 3 hits
PfamiView protein in Pfam
PF00616 RasGAP, 1 hit
SMARTiView protein in SMART
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6CMT2_KLULA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6CMT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 31, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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