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Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51ATPPROSITE-ProRule annotation1
Active sitei143Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
Ordered Locus Names:KLLA0F20053g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002896941 – 444Mitogen-activated protein kinase HOG1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphothreonineBy similarity1
Modified residuei175PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-173 and Tyr-175, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi284590.XP_455981.1

Structurei

3D structure databases

ProteinModelPortaliQ6CJA8
SMRiQ6CJA8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 301Protein kinasePROSITE-ProRule annotationAdd BLAST280

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi173 – 175TXY3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi374 – 403Gln-richAdd BLAST30

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ6CJA8
KOiK04441
OMAiDVIDTIC
OrthoDBiEOG092C2FL8

Family and domain databases

CDDicd07856 STKc_Sty1_Hog1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008352 MAPK_p38-like
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01773 P38MAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00221 MIP, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CJA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEEFIRTQ IFGTVFEITN RYTNLNPVGM GAFGLVCSAT DTLTSQPVAI
60 70 80 90 100
KKIMKPFSTS VLAKRTYREL KLLKHLRHEN LICLEDIFLS PLEDIYFVTE
110 120 130 140 150
LQGTDLHRLL QTRPLEKQFV QYFLYQILRG LKYVHSAGVI HRDLKPSNIL
160 170 180 190 200
INENCDLKIC DFGLARIQDP QMTGYVSTRY YRAPEIMLTW QKYNVEVDIW
210 220 230 240 250
SAGCIFAEMI EGKPLFPGKD HVHQFSIITD LLGSPPKDVI DTICSENTLK
260 270 280 290 300
FVTSLPHRDP VPFSSRFQNL EPDAIDLLEK MLVFDPKKRI TAADALAHPY
310 320 330 340 350
LSPYHDPTDE PIAEAKFDWN FNDADLPVDT WRVMMYSEIL DFHQIGDPQI
360 370 380 390 400
NTNATFDDQV AAATVAAAEA ASKQQQQQQH QTEEQTQQTI ASTPPQAQVT
410 420 430 440
PQQLESGANS NSNSNPSFSI GPDPANETLT NFANQADQYV SKFK
Length:444
Mass (Da):50,298
Last modified:August 16, 2004 - v1
Checksum:iCEA1CB7A1849891D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA Translation: CAG98689.1
RefSeqiXP_455981.1, XM_455981.1

Genome annotation databases

EnsemblFungiiCAG98689; CAG98689; KLLA0_F20053g
GeneIDi2895492
KEGGikla:KLLA0F20053g

Similar proteinsi

Entry informationi

Entry nameiHOG1_KLULA
AccessioniPrimary (citable) accession number: Q6CJA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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