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Entry version 117 (13 Feb 2019)
Sequence version 1 (16 Aug 2004)
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Protein
Submitted name:

KLLA0F20075p

Gene

KLLA0_F20075g

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi660 – 667ATPPROSITE-ProRule annotation8
Nucleotide bindingi1309 – 1316ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
KLLA0F20075pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:KLLA0_F20075gImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284590 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000598 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome F

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 60HelicalSequence analysisAdd BLAST26
Transmembranei81 – 103HelicalSequence analysisAdd BLAST23
Transmembranei115 – 133HelicalSequence analysisAdd BLAST19
Transmembranei140 – 161HelicalSequence analysisAdd BLAST22
Transmembranei181 – 202HelicalSequence analysisAdd BLAST22
Transmembranei287 – 309HelicalSequence analysisAdd BLAST23
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Transmembranei423 – 441HelicalSequence analysisAdd BLAST19
Transmembranei447 – 466HelicalSequence analysisAdd BLAST20
Transmembranei527 – 551HelicalSequence analysisAdd BLAST25
Transmembranei563 – 587HelicalSequence analysisAdd BLAST25
Transmembranei954 – 975HelicalSequence analysisAdd BLAST22
Transmembranei995 – 1019HelicalSequence analysisAdd BLAST25
Transmembranei1083 – 1109HelicalSequence analysisAdd BLAST27
Transmembranei1179 – 1200HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
284590.XP_455982.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6CJA7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 588ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini624 – 850ABC transporterInterPro annotationAdd BLAST227
Domaini958 – 1238ABC transmembrane type-1InterPro annotationAdd BLAST281
Domaini1275 – 1510ABC transporterInterPro annotationAdd BLAST236

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili463 – 483Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6CJA7

KEGG Orthology (KO)

More...
KOi
K05665

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWRVDA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6CJA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQTVSVSEM ISAVSGNSTA CWLCRDDEGF GPISYFGDFT ICFIDGVLLN
60 70 80 90 100
FAALFMLIFG TYQLVKLSKA EHPGVKYKHD WLLLSRIGLV GCFLLFTSMS
110 120 130 140 150
AYYSSEKHES VTLTSQYTLT LLSIFVALML HWVEYHRSRI SNGVVLFYWL
160 170 180 190 200
FESLFQGSKW INFSIRHAYG DEHELPVSYS VYILTVFQTI SAVMILLLES
210 220 230 240 250
LFEKPLPSYQ RVIESYSKQK RNPVDSAHIF QRLSFSWMTE LMKTGYKKYL
260 270 280 290 300
TEKDLYKLPK SFGSKEISEK FGERWQYQLK HKANPSLSWA MLTTFGGKLL
310 320 330 340 350
LGGTFKVAYD ILQFTQPQLL RILIKFVSDY TSTPEPELPL VKGVMLSLAM
360 370 380 390 400
FFVSVVQTSI LHQYFLNAFD TGMNIKSGLT SVIYQKALVL SNEASASSST
410 420 430 440 450
GDIVNLMSVD VQRLQDLTQW GQIIWSGPFQ IVLCLVSLYK LLGPCMWVGV
460 470 480 490 500
IIMIVMIPIN SVIVRIQKKL QKIQMKNKDE RTRVTSEILN NIKSLKVYGW
510 520 530 540 550
EIPYKAKLDH VRNEKELKNL KKMGCTLALA NFQFNIVPFL VSCSTFAVFV
560 570 580 590 600
YTEERPLSTD LVFPALTLFN LLSFPLAVVP NAISSFIEAS VSINRLFAFL
610 620 630 640 650
TNEELQNDAV LREPKVKNIG DEGVKVNDAT FLWQRKPEYK VALKNINFVA
660 670 680 690 700
KKGELTCIVG KVGSGKSALI QSLLGDLIRV KGFATVHGDV ANVSQVPWIM
710 720 730 740 750
NGTVKDNILF GHKYDPEFYQ LTIKACALSI DLSMLPDGDQ TLVGEKGISL
760 770 780 790 800
SGGQKARLSL ARAVYSRADT YLLDDPLAAV DEHVAKHLIE HVLGPHGLLH
810 820 830 840 850
SKTKVLATNK ITVLSIADSI TLMENGEIIQ QGSYDQVNES TNSPLSKLIA
860 870 880 890 900
EFGKKGKPTP SQSTTSLAKL ASEGIESYSD SKISEITVDI NQLDTENLSE
910 920 930 940 950
AEDLKSLRRA SLATLGSIGF DDNENSARRE HREQGKVKWD IYMEYARACN
960 970 980 990 1000
PRNVCVFLGF LILSMLLAVI GNFWLKHWSE VNTEKGYNPH ATRYLMIYLA
1010 1020 1030 1040 1050
LGVGSALATL IQTIVLWVFC TIHGSKYLHD AMASSVLKAP MSFFETTPIG
1060 1070 1080 1090 1100
RILNRFSNDI YKVDEILGRT FAQFFANVVK VSFTIVVICM ATWQFIFIVL
1110 1120 1130 1140 1150
PLSVLYIYYQ QYYLRTSREL RRLDSVTRSP IYAHFQETLG GLTTIRGYSQ
1160 1170 1180 1190 1200
QNRFVHINQT RVDNNMSAFY PSVNANRWLA FRLEFIGSVI ILAASMLAVI
1210 1220 1230 1240 1250
RLGNGTLTAG MIGLSLSFAL QITQSLNWIV RMTVEVETNI VSVERIKEYA
1260 1270 1280 1290 1300
ELKSEAPYII KDHRPPASWP ESGEIKFVNY STRYRPELEL ILKDIDLHIH
1310 1320 1330 1340 1350
PKEKIGIVGR TGAGKSSLTL ALFRIIEAAS GHIVIDGIPI DSIGLADLRH
1360 1370 1380 1390 1400
GLSIIPQDSQ IFEGTVRENI DPTNRYTDEE IWNALALSHL KDHILGMGSN
1410 1420 1430 1440 1450
GLETMLTEGG SNLSVGQRQL MCLARALLIS SNILILDEAT AAVDVETDQL
1460 1470 1480 1490 1500
IQKTIRNAFK ERTILTIAHR INTIMDSDRI IVLDKGRVTE FDTPQNLLQK
1510
KDSIFYSLCL EAGLTE
Length:1,516
Mass (Da):170,328
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE8B072AE6C2D8F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR382126 Genomic DNA Translation: CAG98690.1

NCBI Reference Sequences

More...
RefSeqi
XP_455982.1, XM_455982.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG98690; CAG98690; KLLA0_F20075g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2895493

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
kla:KLLA0_F20075g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA Translation: CAG98690.1
RefSeqiXP_455982.1, XM_455982.1

3D structure databases

ProteinModelPortaliQ6CJA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_455982.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98690; CAG98690; KLLA0_F20075g
GeneIDi2895493
KEGGikla:KLLA0_F20075g

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
InParanoidiQ6CJA7
KOiK05665
OMAiNEWRVDA

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6CJA7_KLULA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6CJA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: February 13, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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