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UniProtKB - Q6CIY7 (SYM1_KLULA)
Protein
Protein SYM1
Gene
SYM1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Functioni
May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
By similarityGO - Biological processi
- ethanol metabolic process Source: EnsemblFungi
Names & Taxonomyi
Protein namesi | Recommended name: Protein SYM1 |
Gene namesi | Name:SYM1 Ordered Locus Names:KLLA0F22924g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 39 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 55 – 71 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 98 – 115 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 159 – 175 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234413 | 1 – 195 | Protein SYM1Add BLAST | 195 |
Structurei
3D structure databases
AlphaFoldDBi | Q6CIY7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peroxisomal membrane protein PXMP2/4 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1944, Eukaryota |
HOGENOMi | CLU_049109_8_1_1 |
InParanoidi | Q6CIY7 |
OMAi | TYLSWKT |
Family and domain databases
InterProi | View protein in InterPro IPR007248, Mpv17_PMP22 |
PANTHERi | PTHR11266, PTHR11266, 1 hit |
Pfami | View protein in Pfam PF04117, Mpv17_PMP22, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6CIY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGFVNWYTA SVKRSPRLTN GIMTGSLFGI GDVIAQVGFP EKKGQKYDLA
60 70 80 90 100
RTVRAVVYGS LIFSIIGDSW YKFLNQKVIV KPGKHWTNTA ARVGCDQLLF
110 120 130 140 150
APVGIPMYYG VMSILEGKSL VDAKKKIEDN WWPTLVTNWY VWPAFQLINF
160 170 180 190
SLVPVHHRLF SVNIISIFWN AFLSFKNSIS PSDKKVPVNF PPVPE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382126 Genomic DNA Translation: CAG98810.1 |
RefSeqi | XP_456102.1, XM_456102.1 |
Genome annotation databases
EnsemblFungii | CAG98810; CAG98810; KLLA0_F22924g |
GeneIDi | 2895360 |
KEGGi | kla:KLLA0_F22924g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382126 Genomic DNA Translation: CAG98810.1 |
RefSeqi | XP_456102.1, XM_456102.1 |
3D structure databases
AlphaFoldDBi | Q6CIY7 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28985.XP_456102.1 |
Genome annotation databases
EnsemblFungii | CAG98810; CAG98810; KLLA0_F22924g |
GeneIDi | 2895360 |
KEGGi | kla:KLLA0_F22924g |
Phylogenomic databases
eggNOGi | KOG1944, Eukaryota |
HOGENOMi | CLU_049109_8_1_1 |
InParanoidi | Q6CIY7 |
OMAi | TYLSWKT |
Family and domain databases
InterProi | View protein in InterPro IPR007248, Mpv17_PMP22 |
PANTHERi | PTHR11266, PTHR11266, 1 hit |
Pfami | View protein in Pfam PF04117, Mpv17_PMP22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYM1_KLULA | |
Accessioni | Q6CIY7Primary (citable) accession number: Q6CIY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families