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Protein

Iron-sulfur protein IND1

Gene

IND1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I.1 Publication

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 82ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur protein IND1
Alternative name(s):
Iron-sulfur protein required for NADH dehydrogenase 1
Gene namesi
Name:IND1
Ordered Locus Names:YALI0B18590g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication1
Mutagenesisi245C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication1
Mutagenesisi279C → A or S: No effect. 1 Publication1
Mutagenesisi279C → E: Abolishes most of complex I activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000035252735 – 312Iron-sulfur protein IND1Add BLAST278

Proteomic databases

PRIDEiQ6CE48

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_501064.1

Structurei

3D structure databases

ProteinModelPortaliQ6CE48
SMRiQ6CE48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000079916
InParanoidiQ6CE48
KOiK03593
OMAiPMLNGII
OrthoDBiEOG092C4BLN

Family and domain databases

CDDicd02037 MRP-like, 1 hit
HAMAPiMF_02040 Mrp_NBP35, 1 hit
InterProiView protein in InterPro
IPR019591 Mrp/NBP35_ATP-bd
IPR000808 Mrp_CS
IPR027417 P-loop_NTPase
IPR033756 YlxH/NBP35
PfamiView protein in Pfam
PF10609 ParA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01215 MRP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CE48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFRLIAPI QRSIAIISRL QPITANFHSS PALRSHENPL GIPKSPASAP
60 70 80 90 100
RIPRKTTRRP EPIAGVKKTI VVSSAKGGVG KSTVSVNTAL SLAKRGLRVG
110 120 130 140 150
LLDVDIFGPS IPTMFGLSGE PRMTHEGKLI PMSKFGIQVM SMGFLVDPNK
160 170 180 190 200
AVAWRGLLVQ KALEQLLQDV DWGTLDVLVM DLPPGTGDVQ LTIAQTVKID
210 220 230 240 250
GAIIVSTPQD VALVDVVRGL DLFEKTYTKV LGLVQNMSVF VCPNCNHETH
260 270 280 290 300
IFGVDGAVSK AKSRGLGVLG NVPLDPQICS QSDKGVPVAV SGGVQAKYYD
310
KIAEGVAEQL GV
Length:312
Mass (Da):33,167
Last modified:August 16, 2004 - v1
Checksum:i25F5F96432C8A327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA Translation: CAG83317.1
RefSeqiXP_501064.1, XM_501064.1

Genome annotation databases

EnsemblFungiiCAG83317; CAG83317; YALI0_B18590g
GeneIDi2907193
KEGGiyli:YALI0B18590g

Similar proteinsi

Entry informationi

Entry nameiIND1_YARLI
AccessioniPrimary (citable) accession number: Q6CE48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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