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Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.By similarity

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.By similarity

Cofactori

pyridoxal 5'-phosphateBy similarity

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-aminolevulinate from glycine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. 5-aminolevulinate synthase, mitochondrial (HEM1)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from glycine, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Binding sitei270SubstrateBy similarity1
Binding sitei303Pyridoxal phosphateBy similarity1
Binding sitei331Pyridoxal phosphateBy similarity1
Binding sitei373Pyridoxal phosphateBy similarity1
Active sitei376By similarity1
Binding sitei405Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei406Pyridoxal phosphate; shared with dimeric partnerBy similarity1
Binding sitei491SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processHeme biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:YALI0C06083g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionSequence analysisAdd BLAST18
ChainiPRO_000000124419 – 5635-aminolevulinate synthase, mitochondrialAdd BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ6CCW0

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4952.XP_501502.1

Structurei

3D structure databases

ProteinModelPortaliQ6CCW0
SMRiQ6CCW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000221020
InParanoidiQ6CCW0
KOiK00643
OMAiKQDHTYR
OrthoDBiEOG092C1OK6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR010961 4pyrrol_synth_NH2levulA_synth
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01821 5aminolev_synth, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CCW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLVRQSKK LCPYIGRTSA SSLKQLGNGR LTQKAGQCPI MGKAMGVRGF
60 70 80 90 100
KSDAGSNAES ATVDVHAAVD TSKGTCPHAA QYSPVYPSSR LDNYPFGMTQ
110 120 130 140 150
RGLGKVPTQD AHNATTFNYE SFYENKINAK HQDKSYRYFN NINRLAAEFP
160 170 180 190 200
RAHRGSIEED KVTVWCANDY LGMGRNPVVV DAMHETLDKY GAGAGGTRNI
210 220 230 240 250
AGHNRHAVEL EAAIADLHKK EAALVFSSCY VANDSTLSLL GQALPNCVYF
260 270 280 290 300
SDASNHASMI HGIRHGGSEK VVWKHNDLAD LEAKLARYPK STPKVIAFES
310 320 330 340 350
VYSMCGSIGP IEEICDLADK YGAITFLDEV HAVGMYGPTG AGVAEHLDFE
360 370 380 390 400
HYHSGAQTQR QPIMDRVDIF TGTLGKAYGC VGGYIAGSAK FVDMVRSYAP
410 420 430 440 450
GFIFTTTLPP ATMAGARAAI NYQKATMKDR VAQQTHTRYV KDKLANRGIP
460 470 480 490 500
VVPNPSHIVP VLVGDAQKAK AASDLLLTKH QIYVQAINFP TVPIGQERLR
510 520 530 540 550
VTPTPGHHEG LCDELVAALE DVWQELDLKR VEDWTAEGGL CGVGEGVEVE
560
PLWSEEQLSY GRD
Length:563
Mass (Da):61,237
Last modified:August 16, 2004 - v1
Checksum:iFC7BBC2F382C0170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA Translation: CAG81803.1
RefSeqiXP_501502.1, XM_501502.1

Genome annotation databases

EnsemblFungiiCAG81803; CAG81803; YALI0_C06083g
GeneIDi2909236
KEGGiyli:YALI0C06083g

Similar proteinsi

Entry informationi

Entry nameiHEM1_YARLI
AccessioniPrimary (citable) accession number: Q6CCW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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