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Entry version 101 (31 Jul 2019)
Sequence version 1 (16 Aug 2004)
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Protein

Helicase SWR1

Gene

SWR1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi934 – 941ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SWR1
Ordered Locus Names:YALI0D04961g
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284591 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001300 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome D

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743741 – 1772Helicase SWR1Add BLAST1772

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6CA87

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWR1 chromatin-remodeling complex.

By similarity

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6CA87

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini536 – 609HSAPROSITE-ProRule annotationAdd BLAST74
Domaini921 – 1086Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1470 – 1623Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1037 – 1040DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 868Glu-richAdd BLAST744

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186095

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6CA87

KEGG Orthology (KO)

More...
KOi
K11681

Identification of Orthologs from Complete Genome Data

More...
OMAi
NKPDAFH

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6CA87-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRTQDLAT THANGSVDSA TAPGASKRRR LADPVLDTPV ELLASGRRTS
60 70 80 90 100
GRHRPVEDAS RQATQQQQAP GTPGGRQQRR AAAAAKESLS TPKRAPAKPK
110 120 130 140 150
EKTPKATPKK TPSRRNGRRR SVKVEEVEEE EPEEEEGPEE EEAPEEEVEG
160 170 180 190 200
DDEEEVQVEE EAEPVSLTPL EEKKQELAKL ISDNDSRVRL LFHLKQFVSL
210 220 230 240 250
VFYDPAEAKQ DQSSVWEQVS MRESIIGTRT RLTQFQQNYD LWTKYLERKT
260 270 280 290 300
GGHMRSTRRQ IRSKQGALED DFVIKLKEEM TAVEEEEEEE LVEEEEEEEE
310 320 330 340 350
EEEQEEDEEQ EQQEEEEEEQ EEEVTSRRGS RRSAPTKAKG KSKTASKTSK
360 370 380 390 400
SKSKASSKSK SKSKGKGQAR ASKLSKSRRY VNAVDSSSEE ESDYDPNKPY
410 420 430 440 450
DVSKEVWEPI DTGWLLPDSE DEYYHFDDKF AQHMFPNGVK LKLNVSLKPP
460 470 480 490 500
RVTHPAHLLL DVAEGQTPDN RERLEGFMSS FKLLDEEMTL EEYEEHYERE
510 520 530 540 550
LETLDKINEM KREGVLQGLA DEEEGESLTV AEIRRGFNDP ERSTRPTHWD
560 570 580 590 600
HVVAQACHFA KLMADERKAH VSQAKRLAAA VDQHFRRLEG AEERDKKAQA
610 620 630 640 650
KLLKTMARKM AQDVMRRWKL AEKVVLKKKE QEAKEEERKQ GKKKLKEILE
660 670 680 690 700
NSAQLLEARV RGDNDTPETE EGEKEEVEAV SDDAMSDVDM EDDREQVEVD
710 720 730 740 750
TRDDDELTVE ELRAKYAALD NIKVERAEEE DEEDEENGDD EDEDEEEDDA
760 770 780 790 800
EIEEETETTT PALETPIDTP AEEDEFSSDT DITLDSEDES SSEQESDYEA
810 820 830 840 850
ETTAPGLAAL MGGPKAIEED EEEDDAFVIK EEEEEVEVED DEEEEKADTE
860 870 880 890 900
VDRKVETVSE AVGEAVEEIK SNGVESKPTS NGVDVTELDR VTPERAPAVE
910 920 930 940 950
PPFLLRGTLR AYQQLGLEWL AGLYNNDTNG ILADEMGLGK TIQTISLLSY
960 970 980 990 1000
LACEHHIWGP HLIIVPTSVM LNWEMEFKRF APGFKVMTYY GNPVQRREKR
1010 1020 1030 1040 1050
RGWNKEDTWH VCITSYQLVL QDLFAFRRKR WHYMILDEAH NIKNFRSQRW
1060 1070 1080 1090 1100
QSLLHFNTVR RLLLTGTPLQ NNLMELWSLL YFLMPSSRNQ MDMPGFANLK
1110 1120 1130 1140 1150
DFQEWFSRPI DKMVEGGVDE EAKTTVSKLH QILRPYLLRR LKKDVEKQMP
1160 1170 1180 1190 1200
AKYEHVVYCR LSKRQRYLYD DFMSRAQTRE TLKTGNFLSI INCLMQLRKV
1210 1220 1230 1240 1250
CNHPDLFEVR PIVTSFVQEQ SVITPYERVS DRVKSLLVNT VDGGYAPSEV
1260 1270 1280 1290 1300
SLSFLGFNAE LEDMSTHEAT SFRKYHNVQT VKNRIRELEK FCPAETPEEE
1310 1320 1330 1340 1350
RYNDIEGHYK HMHHASFQQV IGSLKRVEYL HQIALAKKPV YGRNLVEVCT
1360 1370 1380 1390 1400
INTSRLQPDR PEETNESSYH WQLTHLRHPT VQECANNMAP YIERFACITP
1410 1420 1430 1440 1450
KAVTLNMAEL SLGGIGPILQ QRYFKQVTPK KSQRVVVGPP AAIADPFHQA
1460 1470 1480 1490 1500
QVKLSIAFPD KRLLQYDCGK LQRLATLLQD LIAGGHRALI FTQMTKVLDV
1510 1520 1530 1540 1550
LEQFLNIHGL RYMRLDGATK IEQRQLLTER FNTDPKIPVF ILSTRSGGLG
1560 1570 1580 1590 1600
INLTGADTVI FYDSDWNPSM DKQCQDRCHR IGQTRDVHIY RFVSEHTIES
1610 1620 1630 1640 1650
NILKKANQKQ ILDNVVIQDG EFTTDYFNKM SVHDMLGLEP DDDAAPVADT
1660 1670 1680 1690 1700
LNLSGKNLER ALAQAEDADD AAAAKVATKE TNLDVEDFDE TQKENNKGAT
1710 1720 1730 1740 1750
PGSRSTSATP MEKENTGELS SAMDSPTPVA TPDVAVDNGG GDDDDSDSDE
1760 1770
SDSGIGHIDE YMIKFIEDGW FW
Length:1,772
Mass (Da):202,404
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D9C8787FF55D07A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR382130 Genomic DNA Translation: CAG80613.1

NCBI Reference Sequences

More...
RefSeqi
XP_502425.1, XM_502425.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG80613; CAG80613; YALI0_D04961g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2910662

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
yli:YALI0D04961g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382130 Genomic DNA Translation: CAG80613.1
RefSeqiXP_502425.1, XM_502425.1

3D structure databases

SMRiQ6CA87
ModBaseiSearch...

Proteomic databases

PRIDEiQ6CA87

Genome annotation databases

EnsemblFungiiCAG80613; CAG80613; YALI0_D04961g
GeneIDi2910662
KEGGiyli:YALI0D04961g

Phylogenomic databases

HOGENOMiHOG000186095
InParanoidiQ6CA87
KOiK11681
OMAiNKPDAFH

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00573 HSA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWR1_YARLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6CA87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: July 31, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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