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Protein

Chitobiosyldiphosphodolichol beta-mannosyltransferase

Gene

ALG1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc2-Man5 intermediate on the cytoplasmic surface of the ER (By similarity).By similarity

Catalytic activityi

GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT33 Glycosyltransferase Family 33

Names & Taxonomyi

Protein namesi
Recommended name:
Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC:2.4.1.142)
Alternative name(s):
Asparagine-linked glycosylation protein 1
Beta-1,4-mannosyltransferase
GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
Gene namesi
Name:ALG1
Ordered Locus Names:YALI0E34133g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802581 – 463Chitobiosyldiphosphodolichol beta-mannosyltransferaseAdd BLAST463

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_504760.1

Structurei

3D structure databases

ProteinModelPortaliQ6C3K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000216716
InParanoidiQ6C3K2
KOiK03842
OMAiGPQKEHY
OrthoDBiEOG092C312J

Family and domain databases

InterProiView protein in InterPro
IPR026051 ALG1-like
PANTHERiPTHR13036 PTHR13036, 1 hit

Sequencei

Sequence statusi: Complete.

Q6C3K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAWHWSVTL VVIYLAIPVI LYLLTRKDDR KPLSDIRKRK RTIVLVLGDL
60 70 80 90 100
GRSPRMLYHA RSLARSGHKV DLCGYDGAKP FDEILNNDLI KIHHIPLILN
110 120 130 140 150
TRKLPFVVFG ILKVIRQHWL LISLLYKLRG ADYLLVQNPP SIPTLGVVRF
160 170 180 190 200
YNLFLSTRTK VVLDWHNFGY TILALKLPET HPMVKFAKFY EGFFGGRAFV
210 220 230 240 250
HLCVTVLMGQ AMRKTFGMSG RRIVPLHDRP AFHFKPLSES EKLDVLRDFK
260 270 280 290 300
ETLYDDMTAD HKIIVSSTSY TPDENFNILL DALALYDESK LDLPPLRVII
310 320 330 340 350
TGKGPMMPEF LAKVEKLQLK RVSIRTAWLE FADYPRILGA AHLGVSLHES
360 370 380 390 400
SSGYDLPMKV VDMFGCGIPV VSVDYAALSE LVKTNTNGVA VKGHVEMGNT
410 420 430 440 450
FMSLFSNRGK LDNIKRGAMI ESRNTWDQTW VKTVGPLFDI GEYVQQRPDE
460
DYDFSSSSSD DDH
Length:463
Mass (Da):52,711
Last modified:August 16, 2004 - v1
Checksum:i18D986BA71EBF758
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382131 Genomic DNA Translation: CAG80366.1
RefSeqiXP_504760.1, XM_504760.1

Genome annotation databases

EnsemblFungiiCAG80366; CAG80366; YALI0_E34133g
GeneIDi2911951
KEGGiyli:YALI0E34133g

Similar proteinsi

Entry informationi

Entry nameiALG1_YARLI
AccessioniPrimary (citable) accession number: Q6C3K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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