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Protein

Pyruvate kinase

Gene

PYK1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • K+By similarity

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (GPD)
  2. no protein annotated in this organism
  3. Phosphoglycerate mutase (DEHA2E21054g), Phosphoglycerate mutase (DEHA2D12760g)
  4. Enolase 1 (ENO1), Enolase 2 (ENO2)
  5. Pyruvate kinase (PYK1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Metal bindingi55PotassiumBy similarity1
Metal bindingi57PotassiumBy similarity1
Metal bindingi88PotassiumBy similarity1
Metal bindingi89Potassium; via carbonyl oxygenBy similarity1
Sitei244Transition state stabilizerBy similarity1
Metal bindingi246MagnesiumSequence analysis1
Binding sitei269Substrate; via amide nitrogenBy similarity1
Metal bindingi270MagnesiumBy similarity1
Binding sitei270Substrate; via amide nitrogenBy similarity1
Binding sitei302SubstrateBy similarity1
Binding sitei341ADPSequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK1
Ordered Locus Names:DEHA2D11044g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome D

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001121121 – 504Pyruvate kinaseAdd BLAST504

Proteomic databases

PRIDEiQ6BS75

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6BS75
SMRiQ6BS75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

InParanoidiQ6BS75
KOiK00873
OMAiKHEAIEQ
OrthoDBiEOG092C1RXZ

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 2 hits
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6BS75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNASLSWLT KLNTSETPDK VLRRSSIIGT IGPKTNNVDV LVKLRKAGLN
60 70 80 90 100
IVRMNFSHGS YEYHQSVIDN AKQSEEIYKG RPLAIALDTK GPEIRTGTTI
110 120 130 140 150
DDKDYPILPN HEMIFTTDEA YAKKCDDKVM FIDYKNITKV IEAGKIIYID
160 170 180 190 200
DGVVSFEVLQ IVDDKTLKVR SVNSGKICSH KGVNLPGTDV DLPALSEKDK
210 220 230 240 250
ADIKFGVKNG VHMIFASFIR TGDDIKEIRK VLGEEGKDIQ IIAKIENQQG
260 270 280 290 300
VNNFDEILVE TDGVMVARGD LGIEIPAPQV FVVQKQLIAK CNLAAKPVIC
310 320 330 340 350
ATQMLESMTY NPRPTRAEVS DVGNAILDGA DCVMLSGETA KGNYPFEAVS
360 370 380 390 400
MMHNTAIIAE KAIAYQPLHN EIRSLANRPT PTTETCAMAS VSAAYEQDAK
410 420 430 440 450
AIVVLSTSGF TSRLVSKYKP NVPVMMVTRN HRAARYCHLY RGVYPFVYEK
460 470 480 490 500
KTVDNWQEDV ENRLRWAVSE AIDLGIIKKG DSIVTIQGWT RGSGHSNTVR

VVQA
Length:504
Mass (Da):55,714
Last modified:August 16, 2004 - v1
Checksum:iBE5F4E1B571C5595
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382136 Genomic DNA Translation: CAG87106.1
RefSeqiXP_458945.1, XM_458945.1

Genome annotation databases

EnsemblFungiiCAG87106; CAG87106; DEHA2D11044g
GeneIDi2901740
KEGGidha:DEHA2D11044g

Similar proteinsi

Entry informationi

Entry nameiKPYK_DEBHA
AccessioniPrimary (citable) accession number: Q6BS75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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