UniProtKB - Q6BM04 (SET2_DEBHA)
Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
SET2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Functioni
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.By similarity
Catalytic activityi
- L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteinePROSITE-ProRule annotationBy similarityEC:2.1.1.359PROSITE-ProRule annotationBy similarity
GO - Molecular functioni
- histone methyltransferase activity (H3-K36 specific) Source: EnsemblFungi
GO - Biological processi
- ascospore formation Source: EnsemblFungi
- DNA-templated transcription, termination Source: EnsemblFungi
- histone deacetylation Source: EnsemblFungi
- histone H3-K36 dimethylation Source: EnsemblFungi
- histone H3-K36 trimethylation Source: EnsemblFungi
- negative regulation of antisense RNA transcription Source: EnsemblFungi
- negative regulation of histone H3-K14 acetylation Source: EnsemblFungi
- negative regulation of histone H3-K9 acetylation Source: EnsemblFungi
- negative regulation of reciprocal meiotic recombination Source: EnsemblFungi
- positive regulation of histone acetylation Source: EnsemblFungi
- regulation of DNA-dependent DNA replication initiation Source: EnsemblFungi
- regulation of histone exchange Source: EnsemblFungi
- transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
Keywordsi
Molecular function | Methyltransferase, Repressor, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.359By similarity)Alternative name(s): SET domain-containing protein 2 |
Gene namesi | Name:SET2 Ordered Locus Names:DEHA2F09350g |
Organismi | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
Taxonomic identifieri | 284592 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Debaryomyces › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Cytosol
- cytosol Source: EnsemblFungi
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269787 | 1 – 731 | Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST | 731 |
Proteomic databases
PRIDEi | Q6BM04 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 108 | AWSPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 110 – 227 | SETPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 234 – 250 | Post-SETPROSITE-ProRule annotationAdd BLAST | 17 | |
Domaini | 477 – 511 | WWPROSITE-ProRule annotationAdd BLAST | 35 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 539 – 618 | Sequence analysisAdd BLAST | 80 |
Domaini
The AWS and SET domains are necessary for transcription repression.By similarity
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4442, Eukaryota |
HOGENOMi | CLU_008492_1_1_1 |
InParanoidi | Q6BM04 |
OMAi | NHACGED |
OrthoDBi | 453286at2759 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit cd00201, WW, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR035441, TFIIS/LEDGF_dom_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit SM00456, WW, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6BM04-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDMEELDVK AKQYTPQLFL ESEDKTDEAR STFNELQECT YSSKSTGSSG
60 70 80 90 100
QHEHMTCDCY EDWDSDKQQN MACGEDSDCI NRVTSVECSN KFCTCGNDCQ
110 120 130 140 150
NQRFQKKQYA NVTVIQTELK GYGLRANEDI SESSFIYEYI GEVIDEESFR
160 170 180 190 200
KRMIDYDTKK LIHFYFMMLK KDSFIDATMK GSLARFCNHS CNPNAYVDKW
210 220 230 240 250
VVGEKLRMGI FSKRNIQKGE EITFDYNVDR YGAQSQPCYC GEPNCIKWMG
260 270 280 290 300
GKTQTDAALL LPDGISEALG VTHKQERQWL KENKHLRSKQ QSDESIINEA
310 320 330 340 350
FVKSIEVSAL TESDVSKVMG ALMRVQDLNI TQKLIERIYL TSDDSINSSI
360 370 380 390 400
IRVHGYKTLS QTIKAFKDED KELISKILII LAKWPKVTRN KISSSQIEDV
410 420 430 440 450
VKDINTNSND DNLKKLSSDL LAEWGKLQMA YRIPKNIGND KESNSPALYG
460 470 480 490 500
RNARSRSRSR SPDRGKSAEP QHVETDEALP DGWQTAFDPN TQTNYYYHAE
510 520 530 540 550
LGISKWERPI KEVPKGPKGP KALPVSEPIQ RPNSNSNGRS YNEEELTRRE
560 570 580 590 600
EERLKREKEE QFKEIQQKER LLQELILQSQ KELEEKKSFE EKMKLEKLEK
610 620 630 640 650
EKERQALKRK KLKKSKSSIP PAPPVPIDGQ WTKTFAKHVP NFLKKYEAEI
660 670 680 690 700
GRDNIKGCAK ELVKTLVAKE MKKNPDTKPP KELDNAKLKK IKEYSKMFMD
710 720 730
KFLIKYRSKH DKKRSHNEEN GGTKRVKPDV E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382138 Genomic DNA Translation: CAG89108.2 |
RefSeqi | XP_460767.2, XM_460767.1 |
Genome annotation databases
EnsemblFungii | CAG89108; CAG89108; DEHA2F09350g |
GeneIDi | 2903609 |
KEGGi | dha:DEHA2F09350g |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382138 Genomic DNA Translation: CAG89108.2 |
RefSeqi | XP_460767.2, XM_460767.1 |
3D structure databases
SMRi | Q6BM04 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4959.XP_460767.2 |
Proteomic databases
PRIDEi | Q6BM04 |
Genome annotation databases
EnsemblFungii | CAG89108; CAG89108; DEHA2F09350g |
GeneIDi | 2903609 |
KEGGi | dha:DEHA2F09350g |
Phylogenomic databases
eggNOGi | KOG4442, Eukaryota |
HOGENOMi | CLU_008492_1_1_1 |
InParanoidi | Q6BM04 |
OMAi | NHACGED |
OrthoDBi | 453286at2759 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit cd00201, WW, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR035441, TFIIS/LEDGF_dom_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit SM00456, WW, 1 hit |
SUPFAMi | SSF47676, SSF47676, 1 hit SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SET2_DEBHA | |
Accessioni | Q6BM04Primary (citable) accession number: Q6BM04 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 16, 2008 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families