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Entry version 142 (02 Jun 2021)
Sequence version 2 (03 Oct 2012)
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Protein

Nucleosome-remodeling factor subunit NURF301-like

Gene

nurf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates.

Curated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri347 – 392PHD-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1899 – 1950PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri1959 – 2010PHD-type 3PROSITE-ProRule annotationAdd BLAST52

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleosome-remodeling factor subunit NURF301-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nurf-1
ORF Names:F26H11.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
F26H11.2a ; CE46896 ; WBGene00009180 ; nurf-1
F26H11.2b ; CE46841 ; WBGene00009180 ; nurf-1
F26H11.2c ; CE47064 ; WBGene00009180 ; nurf-1
F26H11.2d ; CE42388 ; WBGene00009180 ; nurf-1
F26H11.2e ; CE15909 ; WBGene00009180 ; nurf-1
F26H11.2f ; CE15910 ; WBGene00009180 ; nurf-1
F26H11.2g ; CE37638 ; WBGene00009180 ; nurf-1
F26H11.2h ; CE42387 ; WBGene00009180 ; nurf-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002493211 – 2194Nucleosome-remodeling factor subunit NURF301-likeAdd BLAST2194

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6BER5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6BER5

PeptideAtlas

More...
PeptideAtlasi
Q6BER5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009180, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6BER5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a nucleosome remodeling factor-like (NURF-like) complex containing nurf-1 and isw-1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
40379, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-25937N

Protein interaction database and analysis system

More...
IntActi
Q6BER5, 8 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F26H11.2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6BER5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 256DDT 1PROSITE-ProRule annotationAdd BLAST61
Domaini341 – 396DDT 2PROSITE-ProRule annotationAdd BLAST56
Domaini1883 – 1953DDT 3PROSITE-ProRule annotationAdd BLAST71
Domaini1948 – 2014DDT 4PROSITE-ProRule annotationAdd BLAST67
Domaini2047 – 2117BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 137DisorderedSequence analysisAdd BLAST137
Regioni1091 – 1122DisorderedSequence analysisAdd BLAST32
Regioni1158 – 1255DisorderedSequence analysisAdd BLAST98
Regioni1413 – 1433DisorderedSequence analysisAdd BLAST21
Regioni1657 – 1701DisorderedSequence analysisAdd BLAST45
Regioni1834 – 1888DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1151 – 1187Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 77Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi121 – 137Acidic residuesSequence analysisAdd BLAST17
Compositional biasi1107 – 1122Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1158 – 1183Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1204 – 1240Polar residuesSequence analysisAdd BLAST37
Compositional biasi1415 – 1433Polar residuesSequence analysisAdd BLAST19
Compositional biasi1666 – 1701Polar residuesSequence analysisAdd BLAST36
Compositional biasi1847 – 1878Basic and acidic residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BPTF family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri347 – 392PHD-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1899 – 1950PHD-type 2PROSITE-ProRule annotationAdd BLAST52
Zinc fingeri1959 – 2010PHD-type 3PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1473, Eukaryota
KOG1632, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000284_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6BER5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FECAIRR

Database of Orthologous Groups

More...
OrthoDBi
180712at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038028, BPTF
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018501, DDT_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45975, PTHR45975, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF00628, PHD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00249, PHD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform c (identifier: Q6BER5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPRGRSKR KHPSESGNSS IADSEDPSES TSSSRPRRSR LPKRYFDDGY
60 70 80 90 100
SPPPTKKRAA QRETPSDAEE VEVKIEEISV RSTPASTPAP KSTSKARGRP
110 120 130 140 150
KKNPTPPRRK SLKRQEEDII YMDEDSEEEE ESSDDEFMLN EDQVVQEEEE
160 170 180 190 200
ELNLTDIKIE KGLDEENKYC PWLDEDPASL PKLELPESSQ DIPIPTASIM
210 220 230 240 250
DAVEIYEILR SYHRTLRITP FTFEDFCAAL ISHNNSCIMA EVHMALLRNC
260 270 280 290 300
LKSDDEEQTH YSVTETNNSV NIMIHHMDTL TYAEILRQYI EAYPFADASV
310 320 330 340 350
RDAINVDNYP FVGYDAKLVV LLFMSYRFLY SSEFKKLVNN VGKFQNDENC
360 370 380 390 400
RVCGKSSGRV VGCTQCEAAF HVECSHLKPF PEVLVCNICK KNSAVRGVLP
410 420 430 440 450
PDEAVDREPL RSQPIGRDRY GRYYWFIVRR LVVQSLDETE LYYYSTVPQL
460 470 480 490 500
YQLLQKLDRT YYEKDLCDTI RLRIDEFLEQ MALTVEMTSE RREAALETMV
510 520 530 540 550
KRQLIGYDFA EATTPQIYLH RDSMKRMASI LRDCAQKGQV KQEVKLEEPV
560 570 580 590 600
EGQSPVKCVQ FVEDSILPES MIGIFDAKLI NTFWSGGATQ EELVEQFVDI
610 620 630 640 650
SDNFDAPSAN LWRMGDEGND QTFMTYYNYY SRNEMSESFL TRKKAADKKK
660 670 680 690 700
YMASKFAQID NFDWVVAKNR QFYGDASLHC KFIMWTLQQV IKNIPIDLMH
710 720 730 740 750
RKWPEFAKGF DLEVSVADDY KKLVTCLLKL DCAVRKTIFM PQWWNGLGQT
760 770 780 790 800
RLERITVDQR ENFMKEQQRL KKIDADALTK DLDDSFVRVN YMKPKWPNTY
810 820 830 840 850
ILRQRGETYR NAGKGSMGGW AWVAAKYVEK WIQVPESPKL PLAVTVEEIK
860 870 880 890 900
TESVSNRKAR RLELLVSKIT KKRQRSGGKS SKKPTFELTN GCYSPSCRSN
910 920 930 940 950
PNRKCYSPMC RNGYLVSAKQ AHDERKLEES GVLGEEKAWP IPEIQTFSTK
960 970 980 990 1000
RGGKSIFVLQ KKILRQMIMG GGCQQVYMPG FSAGIKSNLL IWPYPAPRPT
1010 1020 1030 1040 1050
LDLCWKWQTL NARSLHAVAL QLKIIWSSIK FNEFDPDDTH PDRRVVIDTP
1060 1070 1080 1090 1100
SHDERRRIIR HKEMPPYGQY ERYEMEIEII PLYDEPEEED ESWLSRNRGG
1110 1120 1130 1140 1150
SSEFSHRSSS ARKKRPQRSL DNRRATAIRR EWVDGVTLKV FEIKDYWKWI
1160 1170 1180 1190 1200
RAEAEKTAKR KLEATRKAQK AKEDEERRRI QQQQQRSVAR IPVPMHSLIP
1210 1220 1230 1240 1250
SERNNVPYLG SQQQRRPNGN ERGFLEKYNN SSSVSPQAHG YASTPPPGYH
1260 1270 1280 1290 1300
QPQPNIIRQA GYNQLPRKPT TSPFNFQSRP VATIPTTPQL RAAAGADGVV
1310 1320 1330 1340 1350
RAVMMTPGNK STVNTNSTPY PQALNRQQYQ LQRQQQQPAV RRLTNGYHFM
1360 1370 1380 1390 1400
DGTMRGGGRN PSVQMHQRLP QNRAALQRPF GESTTEMRRV TEAAIPDNDG
1410 1420 1430 1440 1450
DEQPPVIPRY DPTSNFDAQR AQQQHPQSRP VYSTPAQMIR TTQPGGVKHN
1460 1470 1480 1490 1500
VILMKASDGT QKMVLKPGQF PPGTVISTGQ RVVPYRQPTA VQQRQLYTAT
1510 1520 1530 1540 1550
PGTRVVRIPN ANGGAPRQQD HQVMRRVVQA SGPRAMEYMD DQGTPPPGQQ
1560 1570 1580 1590 1600
VRYVLQGGNS GTPNVNPPKV SSRGGPRGGL TMQMVQQQQQ HNPEHRRLLA
1610 1620 1630 1640 1650
GRQKQKVTTY RDFMASRGYL DTSKFMMQTK PTFLPFEFNE EEEREINEAI
1660 1670 1680 1690 1700
AREEAWMRQE EENKTSGYDS SGNPIRSITS SGDTQRAPPY VSNLLPSSND
1710 1720 1730 1740 1750
SPDDKVIKQV LDVMFSQVCR WDRQYGWSKT HVKRARQKND SDKMHLRKFR
1760 1770 1780 1790 1800
MNQRELLITD HMERLKKEIN KRRTRMENEA EQQCGLLTPW RKARARPHRA
1810 1820 1830 1840 1850
AKPKAEVKKE VINPADITLG GDTYDYVKEQ KPTESIATNV SRRRRTSANL
1860 1870 1880 1890 1900
SKSEDDRDKP ESQSTAPKSK ERRTSEPPAS HVAFHTPGSA TPHDINLSIE
1910 1920 1930 1940 1950
HCTCQKIFDA SKLYIQCELC ARWYHGDCVG VAEQTILGLE HWSCEECIEE
1960 1970 1980 1990 2000
QERVKDQPAL YCVCQKPYDD TKFYVGCDSC QGWFHPECVG TTRAEAEQAA
2010 2020 2030 2040 2050
DYNCPACTRE AEGYESEASD VSGSSRVSVQ LTRADYTHVF ELLELLLEHR
2060 2070 2080 2090 2100
MSTPFRNPVD LNEFPDYEKF IKKPMDLSTI TKKVERTEYL YLSQFVNDVN
2110 2120 2130 2140 2150
QMFENAKTYN PKGNAVFKCA ETMQEVFDKK LIDVREQMTA RQQMLLLATA
2160 2170 2180 2190
QQQDPMSSIR KRVQSESQRT VDSLDIDSDQ LLPLDANLMR LYDF
Length:2,194
Mass (Da):252,195
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A85C3AB3704E93B
GO
Isoform a (identifier: Q6BER5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1745-1745: H → QMFS

Show »
Length:2,197
Mass (Da):252,551
Checksum:i965F4D71C150C834
GO
Isoform b (identifier: Q6BER5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1594-1621: EHRRLLAGRQKQKVTTYRDFMASRGYLD → FQAHYDMPDDATGFAVSTTTEQVPDEQQ
     1622-2194: Missing.

Show »
Length:1,621
Mass (Da):185,717
Checksum:iFF400C89951C0A92
GO
Isoform d (identifier: Q6BER5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1386: Missing.

Show »
Length:808
Mass (Da):92,275
Checksum:iC8FCB6DE7FDCD97C
GO
Isoform e (identifier: Q6BER5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1789: Missing.
     1790-1799: WRKARARPHR → MKALHVFFLP

Show »
Length:405
Mass (Da):46,199
Checksum:iDE6BE7384A5AEB2F
GO
Isoform f (identifier: Q6BER5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1676: Missing.
     1677-1799: SITSSGDTQR...WRKARARPHR → MVLRTVILPT...RCADREISEL

Show »
Length:510
Mass (Da):57,881
Checksum:iC567A57D0DBE160F
GO
Isoform g (identifier: Q6BER5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1626: Missing.
     1627-1875: MQTKPTFLPF...APKSKERRTS → MVLRTVILPT...KKITVFQKPV

Show »
Length:413
Mass (Da):46,959
Checksum:i5C803054D8AB1068
GO
Isoform h (identifier: Q6BER5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1386: Missing.
     1832-2085: Missing.

Show »
Length:554
Mass (Da):63,523
Checksum:iABA4D4048F64F914
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AR10A0A0K3AR10_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
2,196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ARK1A0A0K3ARK1_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
2,075Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3ATY3A0A0K3ATY3_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
2,073Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AUK7A0A0K3AUK7_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
568Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AWW5A0A0K3AWW5_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5S9MQ08A0A5S9MQ08_CAEEL
NURF (Nucleosome remodeling factor)...
nurf-1 CELE_F26H11.2, F26H11.2
2,199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B6VQ92B6VQ92_CAEEL
DDT domain-containing protein
nurf-1 CELE_F26H11.2, F26H11.2
1,619Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2FLJ6H2FLJ6_CAEEL
DDT domain-containing protein
nurf-1 CELE_F26H11.2, F26H11.2
1,621Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GUF5F5GUF5_CAEEL
Bromo domain-containing protein
nurf-1 CELE_F26H11.2, F26H11.2
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A486WW91A0A486WW91_CAEEL
Nucleosome-remodeling factor subuni...
nurf-1 CELE_F26H11.2, F26H11.2
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0204101 – 1789Missing in isoform e. CuratedAdd BLAST1789
Alternative sequenceiVSP_0204111 – 1676Missing in isoform f. CuratedAdd BLAST1676
Alternative sequenceiVSP_0204121 – 1626Missing in isoform g. CuratedAdd BLAST1626
Alternative sequenceiVSP_0204131 – 1386Missing in isoform d and isoform h. CuratedAdd BLAST1386
Alternative sequenceiVSP_0204151594 – 1621EHRRL…RGYLD → FQAHYDMPDDATGFAVSTTT EQVPDEQQ in isoform b. CuratedAdd BLAST28
Alternative sequenceiVSP_0204181622 – 2194Missing in isoform b. CuratedAdd BLAST573
Alternative sequenceiVSP_0204191627 – 1875MQTKP…ERRTS → MVLRTVILPTATYTAPSQYC PSTVLSNLTLSCPYQDQEAD ASLEISDFAEVLPKFESAEQ DWNSFGYLLNEQPGTSSDKT TTPIKKITVFQKPV in isoform g. CuratedAdd BLAST249
Alternative sequenceiVSP_0204201677 – 1799SITSS…ARPHR → MVLRTVILPTATYTAPSQYC PSTVLSNLTLSCPYQDQEAD ASLEISDFAEVLPKFESAEQ DWNSFGYLLNEQPGTSSDKT TTPIKKITVFQKPVEPIGKG PRRRRRCADREISEL in isoform f. CuratedAdd BLAST123
Alternative sequenceiVSP_0442041745H → QMFS in isoform a. Curated1
Alternative sequenceiVSP_0204211790 – 1799WRKARARPHR → MKALHVFFLP in isoform e. Curated10
Alternative sequenceiVSP_0350301832 – 2085Missing in isoform h. CuratedAdd BLAST254

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z81515 Genomic DNA Translation: CAB04195.1
Z81515 Genomic DNA Translation: CAB04197.3
Z81515 Genomic DNA Translation: CAB04198.1
Z81515 Genomic DNA Translation: CAB54234.4
Z81515 Genomic DNA Translation: CAC42289.3
Z81515 Genomic DNA Translation: CAH04722.2
Z81515 Genomic DNA Translation: CAH60782.1
Z81515 Genomic DNA Translation: CAQ16138.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T21430
T21432
T21433
T21435

NCBI Reference Sequences

More...
RefSeqi
NP_001022117.2, NM_001026946.3 [Q6BER5-1]
NP_001022118.2, NM_001026947.5
NP_001022119.1, NM_001026948.3 [Q6BER5-5]
NP_001022120.1, NM_001026949.3 [Q6BER5-6]
NP_001022121.1, NM_001026950.3
NP_001122607.1, NM_001129135.2
NP_496994.3, NM_064593.3 [Q6BER5-2]
NP_496995.3, NM_064594.6 [Q6BER5-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F26H11.2a.1; F26H11.2a.1; WBGene00009180 [Q6BER5-3]
F26H11.2b.1; F26H11.2b.1; WBGene00009180 [Q6BER5-2]
F26H11.2c.1; F26H11.2c.1; WBGene00009180 [Q6BER5-1]
F26H11.2d.1; F26H11.2d.1; WBGene00009180 [Q6BER5-4]
F26H11.2e.1; F26H11.2e.1; WBGene00009180 [Q6BER5-5]
F26H11.2f.1; F26H11.2f.1; WBGene00009180 [Q6BER5-6]
F26H11.2f.2; F26H11.2f.2; WBGene00009180 [Q6BER5-6]
F26H11.2g.1; F26H11.2g.1; WBGene00009180 [Q6BER5-7]
F26H11.2h.1; F26H11.2h.1; WBGene00009180 [Q6BER5-8]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175098

UCSC genome browser

More...
UCSCi
F26H11.2a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81515 Genomic DNA Translation: CAB04195.1
Z81515 Genomic DNA Translation: CAB04197.3
Z81515 Genomic DNA Translation: CAB04198.1
Z81515 Genomic DNA Translation: CAB54234.4
Z81515 Genomic DNA Translation: CAC42289.3
Z81515 Genomic DNA Translation: CAH04722.2
Z81515 Genomic DNA Translation: CAH60782.1
Z81515 Genomic DNA Translation: CAQ16138.1
PIRiT21430
T21432
T21433
T21435
RefSeqiNP_001022117.2, NM_001026946.3 [Q6BER5-1]
NP_001022118.2, NM_001026947.5
NP_001022119.1, NM_001026948.3 [Q6BER5-5]
NP_001022120.1, NM_001026949.3 [Q6BER5-6]
NP_001022121.1, NM_001026950.3
NP_001122607.1, NM_001129135.2
NP_496994.3, NM_064593.3 [Q6BER5-2]
NP_496995.3, NM_064594.6 [Q6BER5-3]

3D structure databases

SMRiQ6BER5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi40379, 13 interactors
DIPiDIP-25937N
IntActiQ6BER5, 8 interactors
STRINGi6239.F26H11.2a

Proteomic databases

EPDiQ6BER5
PaxDbiQ6BER5
PeptideAtlasiQ6BER5

Genome annotation databases

EnsemblMetazoaiF26H11.2a.1; F26H11.2a.1; WBGene00009180 [Q6BER5-3]
F26H11.2b.1; F26H11.2b.1; WBGene00009180 [Q6BER5-2]
F26H11.2c.1; F26H11.2c.1; WBGene00009180 [Q6BER5-1]
F26H11.2d.1; F26H11.2d.1; WBGene00009180 [Q6BER5-4]
F26H11.2e.1; F26H11.2e.1; WBGene00009180 [Q6BER5-5]
F26H11.2f.1; F26H11.2f.1; WBGene00009180 [Q6BER5-6]
F26H11.2f.2; F26H11.2f.2; WBGene00009180 [Q6BER5-6]
F26H11.2g.1; F26H11.2g.1; WBGene00009180 [Q6BER5-7]
F26H11.2h.1; F26H11.2h.1; WBGene00009180 [Q6BER5-8]
GeneIDi175098
UCSCiF26H11.2a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175098
WormBaseiF26H11.2a ; CE46896 ; WBGene00009180 ; nurf-1
F26H11.2b ; CE46841 ; WBGene00009180 ; nurf-1
F26H11.2c ; CE47064 ; WBGene00009180 ; nurf-1
F26H11.2d ; CE42388 ; WBGene00009180 ; nurf-1
F26H11.2e ; CE15909 ; WBGene00009180 ; nurf-1
F26H11.2f ; CE15910 ; WBGene00009180 ; nurf-1
F26H11.2g ; CE37638 ; WBGene00009180 ; nurf-1
F26H11.2h ; CE42387 ; WBGene00009180 ; nurf-1

Phylogenomic databases

eggNOGiKOG1473, Eukaryota
KOG1632, Eukaryota
HOGENOMiCLU_000284_0_0_1
InParanoidiQ6BER5
OMAiFECAIRR
OrthoDBi180712at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6BER5

Gene expression databases

BgeeiWBGene00009180, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiQ6BER5, baseline and differential

Family and domain databases

Gene3Di1.20.920.10, 1 hit
3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR038028, BPTF
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018501, DDT_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45975, PTHR45975, 2 hits
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF02791, DDT, 1 hit
PF00628, PHD, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00571, DDT, 1 hit
SM00249, PHD, 3 hits
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS50827, DDT, 1 hit
PS01359, ZF_PHD_1, 3 hits
PS50016, ZF_PHD_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU301_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6BER5
Secondary accession number(s): B1Q274
, O45407, O45409, O45410, Q5WRM3, Q95ZU8, Q9NLC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 3, 2012
Last modified: June 2, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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