SP5

Functionⁱ

Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	296 – 320	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	326 – 350	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	356 – 378	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone morphogenesis Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
post-anal tail morphogenesis Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor Sp5
Gene namesⁱ	Name:SP5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204335.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14529 SP5
MIMⁱ	609391 gene
neXtProtⁱ	NX_Q6BEB4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	389058
Open Targets More...OpenTargetsⁱ	ENSG00000204335
PharmGKBⁱ	PA134875843

Polymorphism and mutation databases

BioMutaⁱ	SP5
DMDMⁱ	74762296

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047146	1 – 398	Transcription factor Sp5Add BLAST		398

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6BEB4
PaxDbⁱ	Q6BEB4
PeptideAtlas More...PeptideAtlasⁱ	Q6BEB4
PRIDEⁱ	Q6BEB4
ProteomicsDBⁱ	66220

PTM databases

iPTMnetⁱ	Q6BEB4
PhosphoSitePlusⁱ	Q6BEB4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204335 Expressed in 93 organ(s), highest expression level in endocervix
CleanExⁱ	HS_SP5
Genevisibleⁱ	Q6BEB4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074123

HPAⁱ

HPA074123

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	132951, 1 interactor
STRINGⁱ	9606.ENSP00000364430

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6BEB4
SMRⁱ	Q6BEB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	164 – 173	Poly-Pro		10
Compositional biasⁱ	224 – 235	Poly-AlaAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	296 – 320	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	326 – 350	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	356 – 378	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000231067
HOVERGENⁱ	HBG014797
InParanoidⁱ	Q6BEB4
KEGG Orthology (KO) More...KOⁱ	K09195
OMAⁱ	EDIPWWS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	Q6BEB4
TreeFamⁱ	TF350150

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6BEB4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA 
        60         70         80         90        100
PPDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH 
       110        120        130        140        150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA 
       160        170        180        190        200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP NPAPDDLPWW SIPQAGAGPG 
       210        220        230        240        250
ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY 
       260        270        280        290        300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV 
       310        320        330        340        350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH 
       360        370        380        390 
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL

Length:398

Mass (Da):41,964

Last modified:September 13, 2004 - v1

Checksum:ⁱBC2C27EE3ED499FA

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052713	75	A → T. Corresponds to variant dbSNP:rs3749036Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB096175 mRNA Translation: BAD34944.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33322.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001003845.1, NM_001003845.2
UniGeneⁱ	Hs.368802

Genome annotation databases

Ensemblⁱ	ENST00000375281; ENSP00000364430; ENSG00000204335
GeneIDⁱ	389058
KEGGⁱ	hsa:389058
UCSC genome browser More...UCSCⁱ	uc002uge.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6BEB4	Transcription factor Sp5		MOUSE		398	UniRef90_Q9JHX2
Sp5 transcription factor		RAT		398
Uncharacterized protein		AOTNA		400
transcription factor Sp5		DIPOR		400
Uncharacterized protein		FELCA		399
+87

Protein	Similar proteins		Species	Score	Length	Source
Q6BEB4	Transcription factor Sp5		MOUSE		398	UniRef50_Q9JHX2
Sp5 transcription factor		RAT		398
Uncharacterized protein		AOTNA		400
transcription factor Sp5		DIPOR		400
transcription factor Sp5		Yangtze finless porpoise		399
+117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB096175 mRNA Translation: BAD34944.1
CCDSⁱ	CCDS33322.1
RefSeqⁱ	NP_001003845.1, NM_001003845.2
UniGeneⁱ	Hs.368802

3D structure databases

ProteinModelPortalⁱ	Q6BEB4
SMRⁱ	Q6BEB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	132951, 1 interactor
STRINGⁱ	9606.ENSP00000364430

PTM databases

iPTMnetⁱ	Q6BEB4
PhosphoSitePlusⁱ	Q6BEB4

Polymorphism and mutation databases

BioMutaⁱ	SP5
DMDMⁱ	74762296

Proteomic databases

MaxQBⁱ	Q6BEB4
PaxDbⁱ	Q6BEB4
PeptideAtlasⁱ	Q6BEB4
PRIDEⁱ	Q6BEB4
ProteomicsDBⁱ	66220

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000375281; ENSP00000364430; ENSG00000204335
GeneIDⁱ	389058
KEGGⁱ	hsa:389058
UCSCⁱ	uc002uge.4 human

Organism-specific databases

CTDⁱ	389058
DisGeNETⁱ	389058
EuPathDBⁱ	HostDB:ENSG00000204335.3
GeneCardsⁱ	SP5
HGNCⁱ	HGNC:14529 SP5
HPAⁱ	HPA074123
MIMⁱ	609391 gene
neXtProtⁱ	NX_Q6BEB4
OpenTargetsⁱ	ENSG00000204335
PharmGKBⁱ	PA134875843
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000231067
HOVERGENⁱ	HBG014797
InParanoidⁱ	Q6BEB4
KOⁱ	K09195
OMAⁱ	EDIPWWS
OrthoDBⁱ	EOG091G0HX6
PhylomeDBⁱ	Q6BEB4
TreeFamⁱ	TF350150

Miscellaneous databases

GenomeRNAiⁱ	389058
Protein Ontology More...PROⁱ	PR:Q6BEB4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204335 Expressed in 93 organ(s), highest expression level in endocervix
CleanExⁱ	HS_SP5
Genevisibleⁱ	Q6BEB4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SP5_HUMAN
Accessionⁱ	Q6BEB4Primary (citable) accession number: Q6BEB4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	September 13, 2004
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6BEB4 (SP5_HUMAN)

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Transcription factor Sp5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ