We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q6BEB4 (SP5_HUMAN)
Protein
Transcription factor Sp5
Gene
SP5
Organism
Homo sapiens (Human)
Status
Functioni
Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 326 – 350 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 356 – 378 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- bone morphogenesis Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- post-anal tail morphogenesis Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6BEB4 |
SignaLinki | Q6BEB4 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sp5 |
Gene namesi | Name:SP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14529, SP5 |
MIMi | 609391, gene |
neXtProti | NX_Q6BEB4 |
VEuPathDBi | HostDB:ENSG00000204335 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 389058 |
OpenTargetsi | ENSG00000204335 |
PharmGKBi | PA134875843 |
Miscellaneous databases
Pharosi | Q6BEB4, Tdark |
Genetic variation databases
BioMutai | SP5 |
DMDMi | 74762296 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047146 | 1 – 398 | Transcription factor Sp5Add BLAST | 398 |
Proteomic databases
jPOSTi | Q6BEB4 |
MassIVEi | Q6BEB4 |
MaxQBi | Q6BEB4 |
PaxDbi | Q6BEB4 |
PeptideAtlasi | Q6BEB4 |
PRIDEi | Q6BEB4 |
ProteomicsDBi | 66220 |
PTM databases
iPTMneti | Q6BEB4 |
PhosphoSitePlusi | Q6BEB4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204335, Expressed in endocervix and 107 other tissues |
Genevisiblei | Q6BEB4, HS |
Organism-specific databases
HPAi | ENSG00000204335, Tissue enhanced (cervix) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 132951, 2 interactors |
IntActi | Q6BEB4, 1 interactor |
STRINGi | 9606.ENSP00000364430 |
Miscellaneous databases
RNActi | Q6BEB4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 204 | DisorderedSequence analysisAdd BLAST | 45 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 187 – 195 | 9aaTAD1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 160 – 179 | Pro residuesSequence analysisAdd BLAST | 20 |
Domaini
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 326 – 350 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 356 – 378 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160673 |
HOGENOMi | CLU_019484_5_0_1 |
InParanoidi | Q6BEB4 |
OMAi | NKRSKCH |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q6BEB4 |
TreeFami | TF350150 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q6BEB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA
60 70 80 90 100
PPDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH
110 120 130 140 150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA
160 170 180 190 200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP NPAPDDLPWW SIPQAGAGPG
210 220 230 240 250
ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY
260 270 280 290 300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
310 320 330 340 350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH
360 370 380 390
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052713 | 75 | A → T. Corresponds to variant dbSNP:rs3749036Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096175 mRNA Translation: BAD34944.1 |
CCDSi | CCDS33322.1 |
RefSeqi | NP_001003845.1, NM_001003845.2 |
Genome annotation databases
Ensembli | ENST00000375281; ENSP00000364430; ENSG00000204335 |
GeneIDi | 389058 |
KEGGi | hsa:389058 |
MANE-Selecti | ENST00000375281.4; ENSP00000364430.3; NM_001003845.3; NP_001003845.1 |
UCSCi | uc002uge.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB096175 mRNA Translation: BAD34944.1 |
CCDSi | CCDS33322.1 |
RefSeqi | NP_001003845.1, NM_001003845.2 |
3D structure databases
SMRi | Q6BEB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132951, 2 interactors |
IntActi | Q6BEB4, 1 interactor |
STRINGi | 9606.ENSP00000364430 |
PTM databases
iPTMneti | Q6BEB4 |
PhosphoSitePlusi | Q6BEB4 |
Genetic variation databases
BioMutai | SP5 |
DMDMi | 74762296 |
Proteomic databases
jPOSTi | Q6BEB4 |
MassIVEi | Q6BEB4 |
MaxQBi | Q6BEB4 |
PaxDbi | Q6BEB4 |
PeptideAtlasi | Q6BEB4 |
PRIDEi | Q6BEB4 |
ProteomicsDBi | 66220 |
Protocols and materials databases
Antibodypediai | 53490, 52 antibodies from 21 providers |
DNASUi | 389058 |
Genome annotation databases
Ensembli | ENST00000375281; ENSP00000364430; ENSG00000204335 |
GeneIDi | 389058 |
KEGGi | hsa:389058 |
MANE-Selecti | ENST00000375281.4; ENSP00000364430.3; NM_001003845.3; NP_001003845.1 |
UCSCi | uc002uge.4, human |
Organism-specific databases
CTDi | 389058 |
DisGeNETi | 389058 |
GeneCardsi | SP5 |
HGNCi | HGNC:14529, SP5 |
HPAi | ENSG00000204335, Tissue enhanced (cervix) |
MIMi | 609391, gene |
neXtProti | NX_Q6BEB4 |
OpenTargetsi | ENSG00000204335 |
PharmGKBi | PA134875843 |
VEuPathDBi | HostDB:ENSG00000204335 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160673 |
HOGENOMi | CLU_019484_5_0_1 |
InParanoidi | Q6BEB4 |
OMAi | NKRSKCH |
OrthoDBi | 1085860at2759 |
PhylomeDBi | Q6BEB4 |
TreeFami | TF350150 |
Enzyme and pathway databases
PathwayCommonsi | Q6BEB4 |
SignaLinki | Q6BEB4 |
Miscellaneous databases
BioGRID-ORCSi | 389058, 10 hits in 1064 CRISPR screens |
GenomeRNAii | 389058 |
Pharosi | Q6BEB4, Tdark |
PROi | PR:Q6BEB4 |
RNActi | Q6BEB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204335, Expressed in endocervix and 107 other tissues |
Genevisiblei | Q6BEB4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SP5_HUMAN | |
Accessioni | Q6BEB4Primary (citable) accession number: Q6BEB4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | February 23, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families