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Protein

Transcription factor Sp5

Gene

SP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp5
Gene namesi
Name:SP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000204335.3
HGNCiHGNC:14529 SP5
MIMi609391 gene
neXtProtiNX_Q6BEB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi389058
OpenTargetsiENSG00000204335
PharmGKBiPA134875843

Polymorphism and mutation databases

BioMutaiSP5
DMDMi74762296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471461 – 398Transcription factor Sp5Add BLAST398

Proteomic databases

MaxQBiQ6BEB4
PaxDbiQ6BEB4
PeptideAtlasiQ6BEB4
PRIDEiQ6BEB4
ProteomicsDBi66220

PTM databases

iPTMnetiQ6BEB4
PhosphoSitePlusiQ6BEB4

Expressioni

Gene expression databases

BgeeiENSG00000204335 Expressed in 93 organ(s), highest expression level in endocervix
CleanExiHS_SP5
GenevisibleiQ6BEB4 HS

Organism-specific databases

HPAiHPA074123

Interactioni

Protein-protein interaction databases

BioGridi132951, 1 interactor
STRINGi9606.ENSP00000364430

Structurei

3D structure databases

ProteinModelPortaliQ6BEB4
SMRiQ6BEB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi164 – 173Poly-Pro10
Compositional biasi224 – 235Poly-AlaAdd BLAST12

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG014797
InParanoidiQ6BEB4
KOiK09195
OMAiEDIPWWS
OrthoDBiEOG091G0HX6
PhylomeDBiQ6BEB4
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q6BEB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA
60 70 80 90 100
PPDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH
110 120 130 140 150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA
160 170 180 190 200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP NPAPDDLPWW SIPQAGAGPG
210 220 230 240 250
ASGVPGSGLS GACAGAPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY
260 270 280 290 300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
310 320 330 340 350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH
360 370 380 390
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KREDARDL
Length:398
Mass (Da):41,964
Last modified:September 13, 2004 - v1
Checksum:iBC2C27EE3ED499FA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05271375A → T. Corresponds to variant dbSNP:rs3749036Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096175 mRNA Translation: BAD34944.1
CCDSiCCDS33322.1
RefSeqiNP_001003845.1, NM_001003845.2
UniGeneiHs.368802

Genome annotation databases

EnsembliENST00000375281; ENSP00000364430; ENSG00000204335
GeneIDi389058
KEGGihsa:389058
UCSCiuc002uge.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096175 mRNA Translation: BAD34944.1
CCDSiCCDS33322.1
RefSeqiNP_001003845.1, NM_001003845.2
UniGeneiHs.368802

3D structure databases

ProteinModelPortaliQ6BEB4
SMRiQ6BEB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132951, 1 interactor
STRINGi9606.ENSP00000364430

PTM databases

iPTMnetiQ6BEB4
PhosphoSitePlusiQ6BEB4

Polymorphism and mutation databases

BioMutaiSP5
DMDMi74762296

Proteomic databases

MaxQBiQ6BEB4
PaxDbiQ6BEB4
PeptideAtlasiQ6BEB4
PRIDEiQ6BEB4
ProteomicsDBi66220

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375281; ENSP00000364430; ENSG00000204335
GeneIDi389058
KEGGihsa:389058
UCSCiuc002uge.4 human

Organism-specific databases

CTDi389058
DisGeNETi389058
EuPathDBiHostDB:ENSG00000204335.3
GeneCardsiSP5
HGNCiHGNC:14529 SP5
HPAiHPA074123
MIMi609391 gene
neXtProtiNX_Q6BEB4
OpenTargetsiENSG00000204335
PharmGKBiPA134875843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG014797
InParanoidiQ6BEB4
KOiK09195
OMAiEDIPWWS
OrthoDBiEOG091G0HX6
PhylomeDBiQ6BEB4
TreeFamiTF350150

Miscellaneous databases

GenomeRNAii389058
PROiPR:Q6BEB4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204335 Expressed in 93 organ(s), highest expression level in endocervix
CleanExiHS_SP5
GenevisibleiQ6BEB4 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP5_HUMAN
AccessioniPrimary (citable) accession number: Q6BEB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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