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Entry version 96 (08 May 2019)
Sequence version 1 (13 Sep 2004)
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Protein

Plexin-A4

Gene

plxna4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-399954 Sema3A PAK dependent Axon repulsion
R-DRE-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DRE-399956 CRMPs in Sema3A signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-A4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:plxna4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-4663 plxna4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 1246ExtracellularSequence analysisAdd BLAST1220
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1247 – 1267HelicalSequence analysisAdd BLAST21
Topological domaini1268 – 1903CytoplasmicSequence analysisAdd BLAST636

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024028527 – 1903Plexin-A4Add BLAST1877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi97 ↔ 106PROSITE-ProRule annotation
Disulfide bondi132 ↔ 140PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi291 ↔ 413PROSITE-ProRule annotation
Disulfide bondi307 ↔ 364PROSITE-ProRule annotation
Disulfide bondi382 ↔ 401PROSITE-ProRule annotation
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi518 ↔ 535PROSITE-ProRule annotation
Disulfide bondi524 ↔ 566PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi538 ↔ 550PROSITE-ProRule annotation
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi601 ↔ 620PROSITE-ProRule annotation
Glycosylationi656N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi663N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi981N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi992N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1025N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1214N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6BEA0

PRoteomics IDEntifications database

More...
PRIDEi
Q6BEA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the embryonic brain expressed in specific subtypes of neurons. Found in the tectal region, hindbrain, neurons in the nucleus of the anterior commissure, posterior commissure, postoptic commissure, medial lateral fascile and epiphysis. Localized to both central and peripheral axons of the primary sensory neurons.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000021195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6BEA0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 515SemaPROSITE-ProRule annotationAdd BLAST489
Domaini517 – 567PSI 1Add BLAST51
Domaini663 – 710PSI 2Add BLAST48
Domaini811 – 864PSI 3Add BLAST54
Domaini866 – 960IPT/TIG 1Add BLAST95
Domaini962 – 1046IPT/TIG 2Add BLAST85
Domaini1049 – 1148IPT/TIG 3Add BLAST100
Domaini1151 – 1246IPT/TIG 4Add BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410XR88 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231377

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6BEA0

KEGG Orthology (KO)

More...
KOi
K06820

Database of Orthologous Groups

More...
OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6BEA0

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6BEA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFHNRRWNF TFSCCVVVLL LPLVAARPQQ PSAATRVHEE YSTFRVENTE
60 70 80 90 100
WTFNHLAVDH RNGNVYLGAV NRIYKLSPGL DIQVSHQTGP DEDNRNCYPP
110 120 130 140 150
RIVQPCSEPL TLTNNVNKML LMDYRENRLL ACGSLYQGIC KLLRLDDLFK
160 170 180 190 200
LGEPFHKKEH YLSGVNESGS VFGVIVSYGD ASPDKLFVAT AVDGRPEYFP
210 220 230 240 250
TISSRKLTRN SEEDGMFAYV FHDEFVASMI KIPSDTFTVV PDFDIYYVYG
260 270 280 290 300
FSSGNFVYFL TLQPEMGGGP TTGSSSAGRE QVYTSKLVRL CKDDTAFNSY
310 320 330 340 350
VEVPLGCVKG GVEYRLLQAA YLSKAGTILA RSLGIGPDDD ILYAVFSKGQ
360 370 380 390 400
KRRPKESSQE SALCVFTLKE INERIKDRLQ SCYKGEGTLD LAWLKVKDIS
410 420 430 440 450
CSSALLTIDD NFCGLDMNAP LGVSEMVRGI PLFSESKDKM TSVIAYVYKN
460 470 480 490 500
HSLAFVGTRG GRLKKIRVDG PTYGALQYET IQVVDNGPIL RDMAFSSDQH
510 520 530 540 550
FLYVMSESQL TRVPVEACEQ YSSCNECLGS GDPHCGWCVL HSMCTRKEKC
560 570 580 590 600
ERSSEPRRFA SNIKQCVRLS VHPNNISVSQ YSVMLVLEAH NVPELSAGVN
610 620 630 640 650
CTFEDLAEMD GLVEGNRITC SSPAEKEVPR IIVDQGDHQI VQLYLKSKET
660 670 680 690 700
GLAFANTSFV FYNCSVHKSC LSCVGSPYQC HWCKYRHTCT HDPSSCSFQE
710 720 730 740 750
GRVKQPEECP QLLPADRILV PVNVVKPITL RAKNLPQPQS GQRGYECVLT
760 770 780 790 800
IQGVEQRVPA LRFNSSSVQC QNTSYMYDGM EMSSLPVDLT VIWNGDFSID
810 820 830 840 850
NPAQNKVHLY KCDARRESCG LCLKADPLFG CVWCKGENRC SLKQHCSYPQ
860 870 880 890 900
SMWLEHNGIN SKCTHPRITK ITPLRGPREG GTLVTIRGEN LGLEFSEIKD
910 920 930 940 950
HVKVADVECT PVPEGYIPAE QIVCEMGKAE RSQFAGNVQV CVGECRPEFM
960 970 980 990 1000
AKSSKYYYFV IPQLLSLKPS RGPISGGTIV NITGGNLDAG SNVSIMFKDQ
1010 1020 1030 1040 1050
KCTYQRRGGQ WITCRSHASM QGYGNVSVSV YVDKAHIHKD LKFEYVEDPT
1060 1070 1080 1090 1100
ITKLEPEWSI FSGNTPLTVS GTNLDIIHTP LIRAKYKNLE TINICQVLSP
1110 1120 1130 1140 1150
TTMQCMAPEL PYSISKHKDV PERPDEFGFI LDNVQSVLAL NNTNFVYYPN
1160 1170 1180 1190 1200
PVFEPLSVSG VQELKPGSPI ILKGRNFLPP TPGGNGKLNY TVLIGDKPCA
1210 1220 1230 1240 1250
LTVSDTQLLC ESPNLTGRHK VLARVGGIEF SPGVVHITSD SPLSSTAVIS
1260 1270 1280 1290 1300
IAGAGGLLIF FIVIVLIAYK RKSRESDLTL KRLQMQMDNL ESRVALECKE
1310 1320 1330 1340 1350
AFAELQTDIH ELTSDLDGAG IPFLDYRTYT MRVLFPGIEE HPVLRDLEVP
1360 1370 1380 1390 1400
GYRQEQVEKG LKLFGQLINN KVFLLSFIRT LESQRGFSMR DRGNVASLIM
1410 1420 1430 1440 1450
TVLQSKLEYA TDVLKHLLSD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW
1460 1470 1480 1490 1500
FTFLLYKFLK ECAGEPLFSL FCAIKQQMEK GPIDSITGEA RYSLSEDKLI
1510 1520 1530 1540 1550
RQQIDYKTLV VNCMHPDNEK SPEVQVKVLN CDTVSQVKEK ILDAIYKNVP
1560 1570 1580 1590 1600
YSHRPKASDM DLEWRQGRVV RVILQDEDVT TKIEADWKRL NMLSHYQVTD
1610 1620 1630 1640 1650
NAVVALVPKQ VTAYNSVNNS TVSRTSASKY ENMIKYTGSP DSLRSRTPMI
1660 1670 1680 1690 1700
TPDLESGVKV WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL LATKGTLQKF
1710 1720 1730 1740 1750
VDDLFETIFS TAHRGSALPL AIKYMFDFLD EQADKHNIHD PHVRHTWKSN
1760 1770 1780 1790 1800
CLPLRFWVNV IKNPQFVFDI HKSSITDACL SVVAQTFMDS CSTSEHRLGK
1810 1820 1830 1840 1850
DSPSNKLLYA KDIPSYKSWV ERYYSDISKM PAISDQDMNA YLAEQSRMHM
1860 1870 1880 1890 1900
NEFNTMSSLS EIYSYIGKYT EEIVSALEQD DGARKQRLAY KLEQVVAFMS

LES
Length:1,903
Mass (Da):213,792
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2345B10968071612
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
T1ECS6T1ECS6_DANRE
Plexin-A4
plxna4
1,903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti974I → V in CAI21292 (PubMed:23594743).Curated1
Sequence conflicti974I → V in CAK10809 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB103158 mRNA Translation: BAD35133.1
BX537358, BX649446 Genomic DNA Translation: CAI21292.1
BX649446, BX537358 Genomic DNA Translation: CAK10809.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004495.1, NM_001004495.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
325938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:325938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103158 mRNA Translation: BAD35133.1
BX537358, BX649446 Genomic DNA Translation: CAI21292.1
BX649446, BX537358 Genomic DNA Translation: CAK10809.1
RefSeqiNP_001004495.1, NM_001004495.1

3D structure databases

SMRiQ6BEA0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000021195

Proteomic databases

PaxDbiQ6BEA0
PRIDEiQ6BEA0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi325938
KEGGidre:325938

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91584
ZFINiZDB-GENE-030131-4663 plxna4

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
HOGENOMiHOG000231377
InParanoidiQ6BEA0
KOiK06820
OrthoDBi90434at2759
PhylomeDBiQ6BEA0
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-DRE-399954 Sema3A PAK dependent Axon repulsion
R-DRE-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DRE-399956 CRMPs in Sema3A signaling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6BEA0

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR041362 TIG2_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
PF18020 TIG_2, 1 hit
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXA4_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6BEA0
Secondary accession number(s): Q5RHC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2004
Last modified: May 8, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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