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Protein

PML-RARA-regulated adapter molecule 1

Gene

Pram1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in integrin signaling in neutrophils. Binds to PtdIns4P.1 Publication

GO - Molecular functioni

GO - Biological processi

  • integrin-mediated signaling pathway Source: MGI
  • regulation of neutrophil degranulation Source: MGI

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PML-RARA-regulated adapter molecule 1
Short name:
PRAM-1
Gene namesi
Name:Pram1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3576625 Pram1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Mice are healthy and do not display any obvious abnormality. They have normal hematopoietic differentiation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002701721 – 675PML-RARA-regulated adapter molecule 1Add BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei374PhosphoserineCombined sources1

Post-translational modificationi

May be phosphorylated on tyrosines.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6BCL1
PaxDbiQ6BCL1
PRIDEiQ6BCL1

PTM databases

iPTMnetiQ6BCL1
PhosphoSitePlusiQ6BCL1

Expressioni

Tissue specificityi

Expressed in bone marrow and mature neutrophils. Weakly expressed in macrophages and mast cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000032739 Expressed in 20 organ(s), highest expression level in bone marrow
CleanExiMM_PRAM1
ExpressionAtlasiQ6BCL1 baseline and differential
GenevisibleiQ6BCL1 MM

Interactioni

Subunit structurei

Interacts with SKAP2, LCP2 and DBNL. May interact with LYN (By similarity). Interacts with NEK6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057065

Structurei

3D structure databases

ProteinModelPortaliQ6BCL1
SMRiQ6BCL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini578 – 656SH3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 471Pro-richAdd BLAST399

Domaini

The SH3 domain binds to PtdIns4P.By similarity

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410J0FT Eukaryota
ENOG410YKSE LUCA
GeneTreeiENSGT00530000063460
HOGENOMiHOG000168515
HOVERGENiHBG082165
InParanoidiQ6BCL1
KOiK19994
OMAiFPKKPPQ
OrthoDBiEOG091G10IJ
TreeFamiTF337003

Family and domain databases

InterProiView protein in InterPro
IPR029294 hSH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14603 hSH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6BCL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSNQDFRNL QAKFQTSQPE LGELFRKTPK PELNKVLKKF PQTELSEQPK
60 70 80 90 100
KSSQSELSAV SLKPLQLQFA DLPRKPPQPG VLKKSPQPEF PHLANKPVQA
110 120 130 140 150
EFPRKPLHPE FTGLKKPSQA EFTDLKKPPQ PQFASLPKKP PKPEFGELSK
160 170 180 190 200
RPPQLETPQE PSAPPAQKLL KPEPNNPARP LGELKPKMFW HLEANEAPKR
210 220 230 240 250
PLPSESSTFP KKPLQPEAVV GFSRKSQPQS ESIEVSQTSP SKCGSRELDS
260 270 280 290 300
HSPQPDISTF PKNNENFRKP SYPQATGCPK SPKQPMFYEF PQTPPRKPES
310 320 330 340 350
CNPQSHSPLP DFNAFPKKHP QLQPSDLTRA SSEPEVCKVP KKTQKPDPNV
360 370 380 390 400
LSQKPSQPEL GHLPRTSSDP EFNSLPRKFL QPQHGKFFQP EFPKGLPRKP
410 420 430 440 450
KLPGSVSECS LPSASAGSSP QCPLSPGLIV PGIPRWRSED FQVQRPPRRR
460 470 480 490 500
PLPSASSLGH PPAKPALPPG PINIQSFRRA AATAAAVLKT GSSTGTHFQA
510 520 530 540 550
QQPQHIAQNP DEIYELYDAV EATDDSSISP RGRDEMLSTQ QATRWPQQEP
560 570 580 590 600
ELRKKATQPQ QLPATDPKLL KQIRKAEKAE REFRKKFKFE GEIVIHTKMM
610 620 630 640 650
IDPNAKTRRG GGKHLGIRRG EILEVIEFTS KDEMLCRDPK GKYGYVPRTA
660 670
LLPLETEVYD DVSFGDPLDM QPFPR
Length:675
Mass (Da):75,508
Last modified:July 27, 2011 - v2
Checksum:iCD5A2A14949B1732
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYJ5E9PYJ5_MOUSE
PML-RARA-regulated adapter molecule...
Pram1
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537L → P in AAT76049 (PubMed:15572693).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665714 mRNA Translation: AAT76049.1
CT033847 Genomic DNA No translation available.
CCDSiCCDS37569.1
RefSeqiNP_001002842.2, NM_001002842.2
UniGeneiMm.272606
Mm.408916

Genome annotation databases

EnsembliENSMUST00000052079; ENSMUSP00000057065; ENSMUSG00000032739
GeneIDi378460
KEGGimmu:378460
UCSCiuc008byz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665714 mRNA Translation: AAT76049.1
CT033847 Genomic DNA No translation available.
CCDSiCCDS37569.1
RefSeqiNP_001002842.2, NM_001002842.2
UniGeneiMm.272606
Mm.408916

3D structure databases

ProteinModelPortaliQ6BCL1
SMRiQ6BCL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057065

PTM databases

iPTMnetiQ6BCL1
PhosphoSitePlusiQ6BCL1

Proteomic databases

MaxQBiQ6BCL1
PaxDbiQ6BCL1
PRIDEiQ6BCL1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052079; ENSMUSP00000057065; ENSMUSG00000032739
GeneIDi378460
KEGGimmu:378460
UCSCiuc008byz.1 mouse

Organism-specific databases

CTDi84106
MGIiMGI:3576625 Pram1

Phylogenomic databases

eggNOGiENOG410J0FT Eukaryota
ENOG410YKSE LUCA
GeneTreeiENSGT00530000063460
HOGENOMiHOG000168515
HOVERGENiHBG082165
InParanoidiQ6BCL1
KOiK19994
OMAiFPKKPPQ
OrthoDBiEOG091G10IJ
TreeFamiTF337003

Miscellaneous databases

PROiPR:Q6BCL1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032739 Expressed in 20 organ(s), highest expression level in bone marrow
CleanExiMM_PRAM1
ExpressionAtlasiQ6BCL1 baseline and differential
GenevisibleiQ6BCL1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029294 hSH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14603 hSH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRAM_MOUSE
AccessioniPrimary (citable) accession number: Q6BCL1
Secondary accession number(s): E9QL42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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