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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Gracilaria tenuistipitata var. liui (Red alga)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Synonyms:odpB
Ordered Locus Names:Grc000123
Encoded oniPlastid; Chloroplast
OrganismiGracilaria tenuistipitata var. liui (Red alga)
Taxonomic identifieri285951 [NCBI]
Taxonomic lineageiEukaryotaRhodophytaFlorideophyceaeRhodymeniophycidaeGracilarialesGracilariaceaeGracilaria

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002801081 – 323Pyruvate dehydrogenase E1 component subunit betaAdd BLAST323

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6B8T1
SMRiQ6B8T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Q6B8T1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEVLMFDAL REATDEEMQN DSSVFILGED VGHYGGSYKV TKDLHSKYGD
60 70 80 90 100
LRVLDTPIAE NSFMGMAIGA AITGLRPIVE GMNMSFLLLA FNQISNNAGM
110 120 130 140 150
LRYTSGGNFQ IPIVIRGPGG VGRQLGAEHS QRLEAYFQAI PGLKIVACST
160 170 180 190 200
PYNAKGLLKS AIRDNNPVIF FEHVLLYNLK DELPNDEYFL PLDKAELVRD
210 220 230 240 250
GLDVTILTYS RMRHHVMQAV VDLVNDGYNP EVIDLISLKP LDITSIAQSL
260 270 280 290 300
MKTHKLIIVE ECMKTGGIGA EIIAQINDNY FDFLDAPIVR LSSQDIPTPY
310 320
NGKLEKATVI YPQQIIEAVK SIV
Length:323
Mass (Da):35,742
Last modified:September 13, 2004 - v1
Checksum:iEF7821FA426BFEED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY673996 Genomic DNA Translation: AAT79704.1
RefSeqiYP_063629.1, NC_006137.1

Genome annotation databases

GeneIDi2943994

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY673996 Genomic DNA Translation: AAT79704.1
RefSeqiYP_063629.1, NC_006137.1

3D structure databases

ProteinModelPortaliQ6B8T1
SMRiQ6B8T1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943994

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiODPB_GRATL
AccessioniPrimary (citable) accession number: Q6B8T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: September 13, 2004
Last modified: December 20, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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