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Entry version 122 (13 Nov 2019)
Sequence version 1 (13 Sep 2004)
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Protein

Dual specificity protein phosphatase 13 isoform A

Gene

DUSP13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by vanadate.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.5 mM for p-nitrophenol phosphate (at pH 6.0)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 13 isoform A (EC:3.1.3.16, EC:3.1.3.482 Publications)
    Short name:
    DUSP13A
    Alternative name(s):
    Branching-enzyme interacting DSP
    Muscle-restricted DSP
    Short name:
    MDSP
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DUSP13
    Synonyms:BEDP, DUSP13A, MDSP
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19681 DUSP13

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    613191 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6B8I1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi97D → A: No effect on interaction with MAP3K5. 1 Publication1
    Mutagenesisi129C → S: Loss of enzyme activity. No effect on interaction with MAP3K5. 2 Publications1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51207

    Open Targets

    More...
    OpenTargetsi
    ENSG00000079393

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134939640

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6B8I1

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DUSP13

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74748394

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003819731 – 188Dual specificity protein phosphatase 13 isoform AAdd BLAST188

    Proteomic databases

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6B8I1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6B8I1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    66209 [Q6B8I1-1]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    Q6B8I1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Skeletal muscle specific.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000079393 Expressed in 104 organ(s), highest expression level in muscle of leg

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6B8I1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6B8I1 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer (PubMed:29106959).

    Interacts with MAP3K5/ASK1; may compete with AKT1 preventing MAP3K5/ASK1 phosphorylation by AKT1.

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119380, 79 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6B8I1, 1 interactor

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1188
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6B8I1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 183Tyrosine-protein phosphataseAdd BLAST147

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154628

    KEGG Orthology (KO)

    More...
    KOi
    K14165

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    WKMGITH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1576308at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6B8I1

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.190.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020417 Atypical_DUSP
    IPR020405 Atypical_DUSP_subfamA
    IPR000340 Dual-sp_phosphatase_cat-dom
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom
    IPR020422 TYR_PHOSPHATASE_DUAL_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00782 DSPc, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR01908 ADSPHPHTASE
    PR01909 ADSPHPHTASEA

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00195 DSPc, 1 hit
    SM00404 PTPc_motif, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52799 SSF52799, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit
    PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
    Note: Additional isoforms seem to exist.

    This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 5 (identifier: Q6B8I1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAETSLPELG GEDKATPCPS ILELEELLRA GKSSCSRVDE VWPNLFIGDA
    60 70 80 90 100
    ATANNRFELW KLGITHVLNA AHKGLYCQGG PDFYGSSVSY LGVPAHDLPD
    110 120 130 140 150
    FDISAYFSSA ADFIHRALNT PGAKVLVHCV VGVSRSATLV LAYLMLHQRL
    160 170 180
    SLRQAVITVR QHRWVFPNRG FLHQLCRLDQ QLRGAGQS
    Note: Produced by alternative promoter usage.
    Length:188
    Mass (Da):20,658
    Last modified:September 13, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88E604BD26E70EE5
    GO
    Isoform 1 (identifier: Q9UII6-1) [UniParc]FASTAAdd to basket
    Also known as: TMDP
    The sequence of this isoform can be found in the external entry Q9UII6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Produced by alternative promoter usage.
    Length:198
    Mass (Da):22,149
    GO
    Isoform 2 (identifier: Q6B8I1-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-188: ATANNRFELW...DQQLRGAGQS → NSIKCAETGG

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    Show »
    Length:60
    Mass (Da):6,337
    Checksum:i83A12286F25BBE7C
    GO
    Isoform 4 (identifier: Q9UII6-4) [UniParc]FASTAAdd to basket
    Also known as: TMDP-L2
    The sequence of this isoform can be found in the external entry Q9UII6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Produced by alternative promoter usage and alternative splicing.
    Length:248
    Mass (Da):27,507
    GO
    Isoform 6 (identifier: Q6B8I1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-67: TANNRFELWKLGITHV → GPYSLPWGSATLPPWH
         68-188: Missing.

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:67
    Mass (Da):7,195
    Checksum:i5B6ED54212DA0242
    GO
    Isoform 7 (identifier: Q6B8I1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         51-92: ATANNRFELW...FYGSSVSYLG → RGPGTASLLV...SCGSWASPTC
         93-188: Missing.

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:92
    Mass (Da):9,746
    Checksum:i4325575165B0055D
    GO
    Isoform 8 (identifier: Q6B8I1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         123-188: AKVLVHCVVG...DQQLRGAGQS → ELVLTPCHGA...DGGSPAWGRP

    Note: Produced by alternative promoter usage and alternative splicing. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:166
    Mass (Da):17,283
    Checksum:i51BBCD025706F2A9
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PSD4E9PSD4_HUMAN
    Dual specificity protein phosphatas...
    DUSP13
    147Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KQA1U3KQA1_HUMAN
    Dual specificity protein phosphatas...
    DUSP13
    220Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KQ82U3KQ82_HUMAN
    Dual-specificity protein phosphatas...
    DUSP13
    334Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KQG1U3KQG1_HUMAN
    Dual-specificity protein phosphatas...
    DUSP13
    260Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    U3KQB7U3KQB7_HUMAN
    Dual-specificity protein phosphatas...
    DUSP13
    193Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH09778 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAF84580 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAF84586 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG51843 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG54592 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
    The sequence BAG62362 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
    The sequence BAG62362 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20S → G in AAH09778 (PubMed:15489334).Curated1
    Sequence conflicti46F → S in BAG62362 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05849573K → R1 PublicationCorresponds to variant dbSNP:rs7912300Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04781951 – 188ATANN…GAGQS → NSIKCAETGG in isoform 2. 1 PublicationAdd BLAST138
    Alternative sequenceiVSP_04644551 – 92ATANN…VSYLG → RGPGTASLLVPWLGRHQVPF LPSPGPRQTTALSCGSWASP TC in isoform 7. 1 PublicationAdd BLAST42
    Alternative sequenceiVSP_04644652 – 67TANNR…GITHV → GPYSLPWGSATLPPWH in isoform 6. 1 PublicationAdd BLAST16
    Alternative sequenceiVSP_04644768 – 188Missing in isoform 6. 1 PublicationAdd BLAST121
    Alternative sequenceiVSP_04644893 – 188Missing in isoform 7. 1 PublicationAdd BLAST96
    Alternative sequenceiVSP_046449123 – 188AKVLV…GAGQS → ELVLTPCHGALPLCHPGTDP AGAAGGSGPGGHTEDGGSPA WGRP in isoform 8. 1 PublicationAdd BLAST66

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY674051 mRNA Translation: AAT79356.1
    AY040091 mRNA Translation: AAK77966.1
    AK057012 mRNA Translation: BAG51843.1 Sequence problems.
    AK127886 mRNA Translation: BAG54592.1 Sequence problems.
    AK291891 mRNA Translation: BAF84580.1 Sequence problems.
    AK291897 mRNA Translation: BAF84586.1 Sequence problems.
    AK300679 mRNA Translation: BAG62362.1 Sequence problems.
    CH471083 Genomic DNA Translation: EAW54564.1
    BC009778 mRNA Translation: AAH09778.1 Sequence problems.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS53542.1 [Q6B8I1-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001007272.1, NM_001007271.1 [Q6B8I1-1]
    NP_001007273.1, NM_001007272.1
    NP_001007274.1, NM_001007273.1
    NP_001307771.1, NM_001320842.1
    NP_001307772.1, NM_001320843.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000308475; ENSP00000311051; ENSG00000079393 [Q6B8I1-5]
    ENST00000372702; ENSP00000361787; ENSG00000079393 [Q6B8I1-1]
    ENST00000394707; ENSP00000452702; ENSG00000079393 [Q6B8I1-2]
    ENST00000479884; ENSP00000474298; ENSG00000079393 [Q6B8I1-4]
    ENST00000494588; ENSP00000474689; ENSG00000079393 [Q6B8I1-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51207

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51207

    UCSC genome browser

    More...
    UCSCi
    uc001jws.4 human [Q6B8I1-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY674051 mRNA Translation: AAT79356.1
    AY040091 mRNA Translation: AAK77966.1
    AK057012 mRNA Translation: BAG51843.1 Sequence problems.
    AK127886 mRNA Translation: BAG54592.1 Sequence problems.
    AK291891 mRNA Translation: BAF84580.1 Sequence problems.
    AK291897 mRNA Translation: BAF84586.1 Sequence problems.
    AK300679 mRNA Translation: BAG62362.1 Sequence problems.
    CH471083 Genomic DNA Translation: EAW54564.1
    BC009778 mRNA Translation: AAH09778.1 Sequence problems.
    CCDSiCCDS53542.1 [Q6B8I1-1]
    RefSeqiNP_001007272.1, NM_001007271.1 [Q6B8I1-1]
    NP_001007273.1, NM_001007272.1
    NP_001007274.1, NM_001007273.1
    NP_001307771.1, NM_001320842.1
    NP_001307772.1, NM_001320843.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    5XJVX-ray1.69A/B1-185[»]
    SMRiQ6B8I1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi119380, 79 interactors
    IntActiQ6B8I1, 1 interactor

    PTM databases

    DEPODiQ6B8I1

    Polymorphism and mutation databases

    BioMutaiDUSP13
    DMDMi74748394

    Proteomic databases

    PeptideAtlasiQ6B8I1
    PRIDEiQ6B8I1
    ProteomicsDBi66209 [Q6B8I1-1]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    51207

    Genome annotation databases

    EnsembliENST00000308475; ENSP00000311051; ENSG00000079393 [Q6B8I1-5]
    ENST00000372702; ENSP00000361787; ENSG00000079393 [Q6B8I1-1]
    ENST00000394707; ENSP00000452702; ENSG00000079393 [Q6B8I1-2]
    ENST00000479884; ENSP00000474298; ENSG00000079393 [Q6B8I1-4]
    ENST00000494588; ENSP00000474689; ENSG00000079393 [Q6B8I1-3]
    GeneIDi51207
    KEGGihsa:51207
    UCSCiuc001jws.4 human [Q6B8I1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51207
    DisGeNETi51207

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    DUSP13
    HGNCiHGNC:19681 DUSP13
    MIMi613191 gene
    neXtProtiNX_Q6B8I1
    OpenTargetsiENSG00000079393
    PharmGKBiPA134939640

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00940000154628
    KOiK14165
    OMAiWKMGITH
    OrthoDBi1576308at2759
    PhylomeDBiQ6B8I1

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    DUSP13 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    DUSP13

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51207
    PharosiQ6B8I1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000079393 Expressed in 104 organ(s), highest expression level in muscle of leg
    ExpressionAtlasiQ6B8I1 baseline and differential
    GenevisibleiQ6B8I1 HS

    Family and domain databases

    Gene3Di3.90.190.10, 1 hit
    InterProiView protein in InterPro
    IPR020417 Atypical_DUSP
    IPR020405 Atypical_DUSP_subfamA
    IPR000340 Dual-sp_phosphatase_cat-dom
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom
    IPR020422 TYR_PHOSPHATASE_DUAL_dom
    PfamiView protein in Pfam
    PF00782 DSPc, 1 hit
    PRINTSiPR01908 ADSPHPHTASE
    PR01909 ADSPHPHTASEA
    SMARTiView protein in SMART
    SM00195 DSPc, 1 hit
    SM00404 PTPc_motif, 1 hit
    SUPFAMiSSF52799 SSF52799, 1 hit
    PROSITEiView protein in PROSITE
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit
    PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDS13A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6B8I1
    Secondary accession number(s): Q96J67
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: September 13, 2004
    Last modified: November 13, 2019
    This is version 122 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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