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Entry version 132 (05 Jun 2019)
Sequence version 3 (16 Jun 2009)
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Protein

Lysine-specific demethylase 4D

Gene

KDM4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.1 Publication

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1362-oxoglutarateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi192Iron; catalyticPROSITE-ProRule annotation1 Publication1
Metal bindingi194Iron; catalyticPROSITE-ProRule annotation1 Publication1
Binding sitei2022-oxoglutarateBy similarity1
Binding sitei2102-oxoglutarateBy similarity1
Metal bindingi238ZincCombined sources1
Metal bindingi244Zinc; via tele nitrogenCombined sources1
Binding sitei2452-oxoglutarateBy similarity1
Metal bindingi280Iron; catalyticPROSITE-ProRule annotation1 Publication1
Metal bindingi310ZincCombined sources1
Metal bindingi312ZincCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
Biological processTranscription, Transcription regulation
LigandIron, Metal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.11.B1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214842 HDMs demethylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysine-specific demethylase 4D (EC:1.14.11.-)
Alternative name(s):
JmjC domain-containing histone demethylation protein 3D
Jumonji domain-containing protein 2D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KDM4D
Synonyms:JHDM3D, JMJD2D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25498 KDM4D

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609766 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6B0I6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55693

Open Targets

More...
OpenTargetsi
ENSG00000186280

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164721552

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6138

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KDM4D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
239938885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343761 – 523Lysine-specific demethylase 4DAdd BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PolyADP-ribosyl glutamic acid1 Publication1
Modified residuei27PolyADP-ribosyl glutamic acid1 Publication1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6B0I6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6B0I6

PeptideAtlas

More...
PeptideAtlasi
Q6B0I6

PRoteomics IDEntifications database

More...
PRIDEi
Q6B0I6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66206

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6B0I6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6B0I6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186280 Expressed in 100 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6B0I6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055854
HPA064037

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120819, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-29606N

Protein interaction database and analysis system

More...
IntActi
Q6B0I6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334181

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6B0I6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1523
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6B0I6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6B0I6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 60JmjNPROSITE-ProRule annotationAdd BLAST43
Domaini146 – 312JmjCPROSITE-ProRule annotationAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 94Poly-Lys4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JHDM3 histone demethylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0958 Eukaryota
ENOG410XP0T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162152

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6B0I6

KEGG Orthology (KO)

More...
KOi
K06709

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSYEEFK

Database of Orthologous Groups

More...
OrthoDBi
1186832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6B0I6

TreeFam database of animal gene trees

More...
TreeFami
TF106449

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003347 JmjC_dom
IPR003349 JmjN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6B0I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METMKSKANC AQNPNCNIMI FHPTKEEFND FDKYIAYMES QGAHRAGLAK
60 70 80 90 100
IIPPKEWKAR ETYDNISEIL IATPLQQVAS GRAGVFTQYH KKKKAMTVGE
110 120 130 140 150
YRHLANSKKY QTPPHQNFED LERKYWKNRI YNSPIYGADI SGSLFDENTK
160 170 180 190 200
QWNLGHLGTI QDLLEKECGV VIEGVNTPYL YFGMWKTTFA WHTEDMDLYS
210 220 230 240 250
INYLHLGEPK TWYVVPPEHG QRLERLAREL FPGSSRGCGA FLRHKVALIS
260 270 280 290 300
PTVLKENGIP FNRITQEAGE FMVTFPYGYH AGFNHGFNCA EAINFATPRW
310 320 330 340 350
IDYGKMASQC SCGEARVTFS MDAFVRILQP ERYDLWKRGQ DRAVVDHMEP
360 370 380 390 400
RVPASQELST QKEVQLPRRA ALGLRQLPSH WARHSPWPMA ARSGTRCHTL
410 420 430 440 450
VCSSLPRRSA VSGTATQPRA AAVHSSKKPS STPSSTPGPS AQIIHPSNGR
460 470 480 490 500
RGRGRPPQKL RAQELTLQTP AKRPLLAGTT CTASGPEPEP LPEDGALMDK
510 520
PVPLSPGLQH PVKASGCSWA PVP
Length:523
Mass (Da):58,603
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5303A0846ECEBA58
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91508 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti510H → R in AAH74739 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057882355S → R. Corresponds to variant dbSNP:rs35631512Ensembl.1
Natural variantiVAR_026225408R → Q2 PublicationsCorresponds to variant dbSNP:rs3740853Ensembl.1
Natural variantiVAR_057883471A → S. Corresponds to variant dbSNP:rs34366036Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001113 mRNA Translation: BAA91508.1 Different initiation.
AK056162 mRNA Translation: BAG51636.1
AP002383 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66952.1
BC074739 mRNA Translation: AAH74739.1
BC119010 mRNA Translation: AAI19011.1
BC122858 mRNA Translation: AAI22859.1
AL137545 mRNA Translation: CAB70803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8302.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T46388

NCBI Reference Sequences

More...
RefSeqi
NP_060509.2, NM_018039.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335080; ENSP00000334181; ENSG00000186280
ENST00000536741; ENSP00000460897; ENSG00000186280
ENST00000610872; ENSP00000482224; ENSG00000186280

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55693

UCSC genome browser

More...
UCSCi
uc001pfe.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001113 mRNA Translation: BAA91508.1 Different initiation.
AK056162 mRNA Translation: BAG51636.1
AP002383 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66952.1
BC074739 mRNA Translation: AAH74739.1
BC119010 mRNA Translation: AAI19011.1
BC122858 mRNA Translation: AAI22859.1
AL137545 mRNA Translation: CAB70803.1
CCDSiCCDS8302.1
PIRiT46388
RefSeqiNP_060509.2, NM_018039.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DXTX-ray1.80A1-354[»]
3DXUX-ray2.20A11-341[»]
4D6QX-ray1.29A1-342[»]
4D6RX-ray1.40A1-342[»]
4D6SX-ray1.40A1-342[»]
4HONX-ray1.80A/B12-341[»]
4HOOX-ray2.50A/B12-341[»]
5F5AX-ray1.41A1-342[»]
5F5CX-ray1.88A1-342[»]
5FP4X-ray2.00A11-341[»]
5FP7X-ray2.00A11-341[»]
5FP8X-ray1.98A11-341[»]
5FP9X-ray2.00A11-341[»]
5FPAX-ray1.96A11-341[»]
5FPBX-ray1.91A11-341[»]
5PH0X-ray1.34A1-342[»]
5PH1X-ray1.25A1-342[»]
5PH2X-ray1.45A1-342[»]
5PH3X-ray1.24A1-342[»]
5PH4X-ray1.27A1-342[»]
5PH5X-ray1.35A1-342[»]
5PH6X-ray1.74A1-342[»]
5PH7X-ray1.43A1-342[»]
5PH8X-ray1.40A1-342[»]
5PH9X-ray1.48A1-342[»]
5PHAX-ray1.45A1-342[»]
5PHBX-ray1.34A1-342[»]
5PHCX-ray1.29A1-342[»]
5PHDX-ray1.36A1-342[»]
5PHEX-ray1.35A1-342[»]
5PHFX-ray1.39A1-342[»]
5PHGX-ray1.40A1-342[»]
5PHHX-ray1.60A1-342[»]
5PHIX-ray1.97A1-342[»]
5PHJX-ray1.15A1-342[»]
5PHKX-ray1.25A1-342[»]
5PHLX-ray1.14A1-342[»]
5PHMX-ray1.40A1-342[»]
5PHNX-ray1.29A1-342[»]
5PHOX-ray1.40A1-342[»]
5PHPX-ray1.72A1-342[»]
5PHQX-ray2.23A1-342[»]
5PHRX-ray1.66A1-342[»]
5PHSX-ray2.54A1-342[»]
5PHTX-ray1.83A1-342[»]
5PHUX-ray1.79A1-342[»]
5PHVX-ray1.83A1-342[»]
5PHWX-ray1.31A1-342[»]
5PHXX-ray1.27A1-342[»]
5PHYX-ray1.34A1-342[»]
5PHZX-ray1.47A1-342[»]
5PI0X-ray1.50A1-342[»]
5PI1X-ray1.34A1-342[»]
5PI2X-ray1.52A1-342[»]
5PI3X-ray1.29A1-342[»]
5PI4X-ray1.35A1-342[»]
5PI5X-ray1.42A1-342[»]
5PI6X-ray1.29A1-342[»]
5PI7X-ray1.61A1-342[»]
5PI8X-ray1.27A1-342[»]
5PI9X-ray1.45A1-342[»]
5PIAX-ray1.18A1-342[»]
5PIBX-ray1.64A1-342[»]
5PICX-ray1.29A1-342[»]
5PIDX-ray1.50A1-342[»]
5PIEX-ray1.42A1-342[»]
5PIFX-ray1.37A1-342[»]
5PIGX-ray1.44A1-342[»]
5PIHX-ray1.79A1-342[»]
5PIIX-ray1.45A1-342[»]
5PIJX-ray1.45A1-342[»]
5PIKX-ray1.80A1-342[»]
5PILX-ray1.65A1-342[»]
5PIMX-ray1.25A1-342[»]
5PINX-ray1.50A1-342[»]
5PIOX-ray1.72A1-342[»]
5PIPX-ray1.42A1-342[»]
5PIQX-ray1.50A1-342[»]
5PIRX-ray1.45A1-342[»]
5PISX-ray1.30A1-342[»]
5PITX-ray1.79A1-342[»]
5PIUX-ray1.48A1-342[»]
5PIVX-ray1.43A1-342[»]
5PIWX-ray1.23A1-342[»]
5PIXX-ray1.35A1-342[»]
5PIYX-ray1.31A1-342[»]
5PIZX-ray1.38A1-342[»]
5PJ0X-ray1.31A1-342[»]
5PJ1X-ray1.35A1-342[»]
5PJ2X-ray1.44A1-342[»]
5PJ3X-ray1.30A1-342[»]
5PJ4X-ray1.52A1-342[»]
5PJ5X-ray1.24A1-342[»]
5PJ6X-ray1.35A1-342[»]
5PJ7X-ray1.39A1-342[»]
5PJ8X-ray1.40A1-342[»]
5PJ9X-ray1.50A1-342[»]
5PJAX-ray1.89A1-342[»]
5PJBX-ray1.58A1-342[»]
5PJCX-ray1.40A1-342[»]
5PJDX-ray1.43A1-342[»]
5PJEX-ray1.37A1-342[»]
5PJFX-ray1.47A1-342[»]
5PJGX-ray1.40A1-342[»]
5PJHX-ray1.18A1-342[»]
5PJIX-ray1.34A1-342[»]
5PJJX-ray1.67A1-342[»]
5PJKX-ray1.69A1-342[»]
5PJLX-ray1.52A1-342[»]
5PJMX-ray1.43A1-342[»]
5PJNX-ray1.48A1-342[»]
5PJOX-ray1.35A1-342[»]
5PJPX-ray1.39A1-342[»]
5PJQX-ray1.38A1-342[»]
5PJRX-ray1.29A1-342[»]
5PJSX-ray1.64A1-342[»]
5PJTX-ray1.54A1-342[»]
5PJUX-ray1.27A1-342[»]
5PJVX-ray1.34A1-342[»]
5PJWX-ray1.56A1-342[»]
5PJXX-ray1.35A1-342[»]
5PJYX-ray1.34A1-342[»]
5PJZX-ray1.29A1-342[»]
5PK0X-ray1.28A1-342[»]
5PK1X-ray1.35A1-342[»]
5PK2X-ray1.42A1-342[»]
5PK3X-ray1.42A1-342[»]
5PK4X-ray1.72A1-342[»]
5PK5X-ray1.39A1-342[»]
5PK6X-ray2.38A1-342[»]
5PK7X-ray1.29A1-342[»]
5PK8X-ray1.44A1-342[»]
5PK9X-ray1.34A1-342[»]
5PKAX-ray1.71A1-342[»]
5PKBX-ray1.40A1-342[»]
5PKCX-ray1.29A1-342[»]
5PKDX-ray1.55A1-342[»]
5PKEX-ray1.44A1-342[»]
5PKFX-ray1.34A1-342[»]
5PKGX-ray1.54A1-342[»]
5PKHX-ray1.19A1-342[»]
5PKIX-ray1.19A1-342[»]
5PKJX-ray1.22A1-342[»]
5PKKX-ray1.50A1-342[»]
5PKLX-ray1.35A1-342[»]
5PKMX-ray1.37A1-342[»]
5PKNX-ray1.30A1-342[»]
5PKOX-ray2.38A1-342[»]
5PKPX-ray1.30A1-342[»]
5PKQX-ray1.28A1-342[»]
5PKRX-ray1.31A1-342[»]
5PKSX-ray1.50A1-342[»]
5PKTX-ray1.50A1-342[»]
5PKUX-ray1.47A1-342[»]
5PKVX-ray1.35A1-342[»]
5PKWX-ray1.35A1-342[»]
5PKXX-ray1.45A1-342[»]
5PKYX-ray1.25A1-342[»]
5PKZX-ray1.50A1-342[»]
5PL0X-ray1.27A1-342[»]
5PL1X-ray1.42A1-342[»]
5PL2X-ray1.34A1-342[»]
5PL3X-ray1.27A1-342[»]
5PL4X-ray1.21A1-342[»]
5PL5X-ray1.57A1-342[»]
5PL6X-ray1.29A1-342[»]
5PL7X-ray1.30A1-342[»]
5PL8X-ray1.54A1-342[»]
5PL9X-ray1.65A1-342[»]
5PLAX-ray1.37A1-342[»]
5PLBX-ray1.49A1-342[»]
5PLCX-ray1.49A1-342[»]
5PLDX-ray1.46A1-342[»]
5PLEX-ray1.45A1-342[»]
5PLFX-ray1.33A1-342[»]
5PLGX-ray1.31A1-342[»]
5PLHX-ray1.46A1-342[»]
5PLIX-ray1.39A1-342[»]
5PLJX-ray1.49A1-342[»]
5PLKX-ray1.14A1-342[»]
5PLLX-ray1.28A1-342[»]
5PLMX-ray1.14A1-342[»]
5PLNX-ray1.14A1-342[»]
5PLOX-ray1.14A1-342[»]
5PLPX-ray1.46A1-342[»]
5PLQX-ray1.36A1-342[»]
5PLRX-ray1.53A1-342[»]
5PLSX-ray1.70A1-342[»]
5PLTX-ray1.53A1-342[»]
5PLUX-ray1.47A1-342[»]
5PLVX-ray1.14A1-342[»]
5PLWX-ray1.31A1-342[»]
5PLXX-ray1.29A1-342[»]
5PLYX-ray1.38A1-342[»]
5PLZX-ray1.71A1-342[»]
5PM0X-ray2.14A1-342[»]
5PM1X-ray1.54A1-342[»]
5PM2X-ray1.52A1-342[»]
5PM3X-ray1.46A1-342[»]
5PM4X-ray1.44A1-342[»]
5PM5X-ray1.76A1-342[»]
5PM6X-ray1.78A1-342[»]
5PM7X-ray1.43A1-342[»]
5PM8X-ray1.54A1-342[»]
5PM9X-ray1.50A1-342[»]
5PMAX-ray1.29A1-342[»]
5PMBX-ray1.63A1-342[»]
5PMCX-ray1.58A1-342[»]
5PMDX-ray1.63A1-342[»]
5PMEX-ray1.39A1-342[»]
5PMFX-ray1.36A1-342[»]
5PMGX-ray1.51A1-342[»]
5PMHX-ray1.52A1-342[»]
5PMIX-ray1.71A1-342[»]
5PMJX-ray1.37A1-342[»]
5PMKX-ray1.44A1-342[»]
5PMLX-ray1.58A1-342[»]
5PMMX-ray1.39A1-342[»]
5PMNX-ray1.72A1-342[»]
5PMOX-ray1.53A1-342[»]
5PMPX-ray1.55A1-342[»]
5PMQX-ray1.46A1-342[»]
5PMRX-ray1.51A1-342[»]
5PMSX-ray1.24A1-342[»]
5PMTX-ray1.22A1-342[»]
5PMUX-ray1.48A1-342[»]
5PMVX-ray1.34A1-342[»]
5PMWX-ray1.19A1-342[»]
5PMXX-ray1.14A1-342[»]
5PMYX-ray1.29A1-342[»]
5PMZX-ray1.15A1-342[»]
5PN0X-ray1.14A1-342[»]
5PN1X-ray1.41A1-342[»]
5PN2X-ray1.41A1-342[»]
5PN3X-ray1.60A1-342[»]
5PN4X-ray1.37A1-342[»]
5PN5X-ray1.30A1-342[»]
5PN6X-ray1.42A1-342[»]
5PN7X-ray1.25A1-342[»]
5PN8X-ray1.34A1-342[»]
5PN9X-ray1.48A1-342[»]
5PNAX-ray1.78A1-342[»]
5PNBX-ray1.23A1-342[»]
5PNCX-ray1.35A1-342[»]
5PNDX-ray1.49A1-342[»]
5PNEX-ray1.29A1-342[»]
5PNFX-ray1.24A1-342[»]
5PNGX-ray1.38A1-342[»]
5PNHX-ray1.14A1-342[»]
5PNIX-ray1.45A1-342[»]
5PNJX-ray1.40A1-342[»]
5PNKX-ray1.27A1-342[»]
5PNLX-ray1.44A1-342[»]
5PNMX-ray1.25A1-342[»]
5PNNX-ray1.21A1-342[»]
5PNOX-ray1.55A1-342[»]
5PNPX-ray1.47A1-342[»]
5PNQX-ray1.47A1-342[»]
5PNRX-ray1.14A1-342[»]
5PNSX-ray1.36A1-342[»]
5PNUX-ray1.14A1-342[»]
5PNVX-ray1.60A1-342[»]
5PNWX-ray1.40A1-342[»]
6ETEX-ray1.47A1-342[»]
6ETGX-ray1.28A1-342[»]
6ETSX-ray1.33A1-341[»]
6ETTX-ray1.26A1-342[»]
6ETUX-ray1.33A1-342[»]
6ETVX-ray1.18A1-342[»]
6ETWX-ray1.35A1-342[»]
6F5QX-ray1.43A1-342[»]
6F5RX-ray1.61A11-337[»]
6F5SX-ray1.48A1-342[»]
6F5TX-ray1.58A11-340[»]
SMRiQ6B0I6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120819, 9 interactors
DIPiDIP-29606N
IntActiQ6B0I6, 6 interactors
STRINGi9606.ENSP00000334181

Chemistry databases

BindingDBiQ6B0I6
ChEMBLiCHEMBL6138

PTM databases

iPTMnetiQ6B0I6
PhosphoSitePlusiQ6B0I6

Polymorphism and mutation databases

BioMutaiKDM4D
DMDMi239938885

Proteomic databases

jPOSTiQ6B0I6
PaxDbiQ6B0I6
PeptideAtlasiQ6B0I6
PRIDEiQ6B0I6
ProteomicsDBi66206

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335080; ENSP00000334181; ENSG00000186280
ENST00000536741; ENSP00000460897; ENSG00000186280
ENST00000610872; ENSP00000482224; ENSG00000186280
GeneIDi55693
KEGGihsa:55693
UCSCiuc001pfe.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55693
DisGeNETi55693

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KDM4D
HGNCiHGNC:25498 KDM4D
HPAiHPA055854
HPA064037
MIMi609766 gene
neXtProtiNX_Q6B0I6
OpenTargetsiENSG00000186280
PharmGKBiPA164721552

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0958 Eukaryota
ENOG410XP0T LUCA
GeneTreeiENSGT00940000162152
HOGENOMiHOG000231125
InParanoidiQ6B0I6
KOiK06709
OMAiPSYEEFK
OrthoDBi1186832at2759
PhylomeDBiQ6B0I6
TreeFamiTF106449

Enzyme and pathway databases

BRENDAi1.14.11.B1 2681
ReactomeiR-HSA-3214842 HDMs demethylate histones

Miscellaneous databases

EvolutionaryTraceiQ6B0I6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
JMJD2D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55693

Protein Ontology

More...
PROi
PR:Q6B0I6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186280 Expressed in 100 organ(s), highest expression level in testis
GenevisibleiQ6B0I6 HS

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR003349 JmjN
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDM4D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6B0I6
Secondary accession number(s): B3KPC4
, Q0VF39, Q9NT41, Q9NW76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 16, 2009
Last modified: June 5, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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