UniProtKB - Q6AZW8 (ZN660_HUMAN)
Protein
Zinc finger protein 660
Gene
ZNF660
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 50 – 72 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 78 – 100 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 106 – 128 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 134 – 156 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 162 – 184 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 190 – 212 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 218 – 240 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 246 – 268 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 296 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 302 – 324 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6AZW8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 660 |
Gene namesi | Name:ZNF660 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144792.9 |
HGNCi | HGNC:26720, ZNF660 |
neXtProti | NX_Q6AZW8 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 285349 |
OpenTargetsi | ENSG00000144792 |
PharmGKBi | PA134920595 |
Miscellaneous databases
Pharosi | Q6AZW8, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF660 |
DMDMi | 74762291 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047701 | 1 – 331 | Zinc finger protein 660Add BLAST | 331 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6AZW8 |
MassIVEi | Q6AZW8 |
MaxQBi | Q6AZW8 |
PaxDbi | Q6AZW8 |
PeptideAtlasi | Q6AZW8 |
PRIDEi | Q6AZW8 |
ProteomicsDBi | 66201 |
PTM databases
iPTMneti | Q6AZW8 |
PhosphoSitePlusi | Q6AZW8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144792, Expressed in lung and 120 other tissues |
ExpressionAtlasi | Q6AZW8, baseline and differential |
Genevisiblei | Q6AZW8, HS |
Organism-specific databases
HPAi | ENSG00000144792, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6AZW8
With | #Exp. | IntAct |
---|---|---|
MAP3K20 - isoform 2 [Q9NYL2-2] | 3 | EBI-12376497,EBI-10255081 |
RNPS1 [Q15287] | 3 | EBI-12376497,EBI-395959 |
SDCBP [O00560] | 3 | EBI-12376497,EBI-727004 |
ZNF124 [Q15973] | 3 | EBI-12376497,EBI-2555767 |
Protein-protein interaction databases
BioGRIDi | 130088, 4 interactors |
IntActi | Q6AZW8, 5 interactors |
STRINGi | 9606.ENSP00000324605 |
Miscellaneous databases
RNActi | Q6AZW8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 50 – 72 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 78 – 100 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 106 – 128 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 134 – 156 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 162 – 184 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 190 – 212 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 218 – 240 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 246 – 268 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 274 – 296 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 302 – 324 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163766 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q6AZW8 |
OMAi | SSQCCDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6AZW8 |
TreeFami | TF337055 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q6AZW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRKTRNFKH KTVKDNKVLT EGSDQESEKD NSQCCDPATN ERVQAEKRQY
60 70 80 90 100
VCTECGKAFS QSANLTVHER IHTGEKPYKC KECGKAFSHS SNLVVHRRIH
110 120 130 140 150
TGLKPYTCSE CGKSFSGKSH LIRHQGIHSG EKTYECKECG KAFSRSSGLI
160 170 180 190 200
SHHRVHTGEK PYSCIECGKA FSRSSNLTQH QRMHRGKKVY KCKECGKTCG
210 220 230 240 250
SNTKIMDHQR IHTGEKPYEC DECGKTFILR KTLNEHQRLH RREKPYKCNE
260 270 280 290 300
CGKAFTSNRN LVDHQRVHTG EKPYKCNECG KTFRQTSQVI LHLRTHTKEK
310 320 330
PYKCSECGKA YRYSSQLIQH QRKHNEEKET S
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J3N9 | C9J3N9_HUMAN | Zinc finger protein 660 | ZNF660 | 39 | Annotation score: | ||
C9J3D4 | C9J3D4_HUMAN | Zinc finger protein 660 | ZNF660 | 34 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | K → N in BAC04303 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094189 mRNA Translation: BAC04303.1 BC075094 mRNA Translation: AAH75094.1 BC075095 mRNA Translation: AAH75095.1 BX538171 mRNA Translation: CAD98047.1 |
CCDSi | CCDS2716.1 |
RefSeqi | NP_775929.2, NM_173658.2 XP_005265147.1, XM_005265090.4 XP_006713180.1, XM_006713117.3 XP_011531924.1, XM_011533622.2 |
Genome annotation databases
Ensembli | ENST00000322734; ENSP00000324605; ENSG00000144792 ENST00000625494; ENSP00000487319; ENSG00000280661 |
GeneIDi | 285349 |
KEGGi | hsa:285349 |
UCSCi | uc003cnl.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094189 mRNA Translation: BAC04303.1 BC075094 mRNA Translation: AAH75094.1 BC075095 mRNA Translation: AAH75095.1 BX538171 mRNA Translation: CAD98047.1 |
CCDSi | CCDS2716.1 |
RefSeqi | NP_775929.2, NM_173658.2 XP_005265147.1, XM_005265090.4 XP_006713180.1, XM_006713117.3 XP_011531924.1, XM_011533622.2 |
3D structure databases
SMRi | Q6AZW8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130088, 4 interactors |
IntActi | Q6AZW8, 5 interactors |
STRINGi | 9606.ENSP00000324605 |
PTM databases
iPTMneti | Q6AZW8 |
PhosphoSitePlusi | Q6AZW8 |
Polymorphism and mutation databases
BioMutai | ZNF660 |
DMDMi | 74762291 |
Proteomic databases
jPOSTi | Q6AZW8 |
MassIVEi | Q6AZW8 |
MaxQBi | Q6AZW8 |
PaxDbi | Q6AZW8 |
PeptideAtlasi | Q6AZW8 |
PRIDEi | Q6AZW8 |
ProteomicsDBi | 66201 |
Protocols and materials databases
Antibodypediai | 12502, 120 antibodies |
Genome annotation databases
Ensembli | ENST00000322734; ENSP00000324605; ENSG00000144792 ENST00000625494; ENSP00000487319; ENSG00000280661 |
GeneIDi | 285349 |
KEGGi | hsa:285349 |
UCSCi | uc003cnl.2, human |
Organism-specific databases
CTDi | 285349 |
DisGeNETi | 285349 |
EuPathDBi | HostDB:ENSG00000144792.9 |
GeneCardsi | ZNF660 |
HGNCi | HGNC:26720, ZNF660 |
HPAi | ENSG00000144792, Low tissue specificity |
neXtProti | NX_Q6AZW8 |
OpenTargetsi | ENSG00000144792 |
PharmGKBi | PA134920595 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163766 |
HOGENOMi | CLU_002678_2_1_1 |
InParanoidi | Q6AZW8 |
OMAi | SSQCCDP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6AZW8 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q6AZW8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 285349, 8 hits in 864 CRISPR screens |
GenomeRNAii | 285349 |
Pharosi | Q6AZW8, Tdark |
PROi | PR:Q6AZW8 |
RNActi | Q6AZW8, protein |
Gene expression databases
Bgeei | ENSG00000144792, Expressed in lung and 120 other tissues |
ExpressionAtlasi | Q6AZW8, baseline and differential |
Genevisiblei | Q6AZW8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN660_HUMAN | |
Accessioni | Q6AZW8Primary (citable) accession number: Q6AZW8 Secondary accession number(s): Q7Z331, Q8N9M8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families