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Protein

Zinc finger protein 660

Gene

ZNF660

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 72C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 660
Gene namesi
Name:ZNF660
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144792.9
HGNCiHGNC:26720 ZNF660
neXtProtiNX_Q6AZW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144792
PharmGKBiPA134920595

Polymorphism and mutation databases

BioMutaiZNF660
DMDMi74762291

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477011 – 331Zinc finger protein 660Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6AZW8
PaxDbiQ6AZW8
PeptideAtlasiQ6AZW8
PRIDEiQ6AZW8
ProteomicsDBi66201

PTM databases

iPTMnetiQ6AZW8
PhosphoSitePlusiQ6AZW8

Expressioni

Gene expression databases

BgeeiENSG00000144792
CleanExiHS_ZNF660
ExpressionAtlasiQ6AZW8 baseline and differential
GenevisibleiQ6AZW8 HS

Organism-specific databases

HPAiHPA029705

Interactioni

Protein-protein interaction databases

IntActiQ6AZW8, 4 interactors
STRINGi9606.ENSP00000324605

Structurei

3D structure databases

ProteinModelPortaliQ6AZW8
SMRiQ6AZW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri50 – 72C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri78 – 100C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri106 – 128C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri134 – 156C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri162 – 184C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133839
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6AZW8
OMAiQRMHKGK
OrthoDBiEOG091G02KC
PhylomeDBiQ6AZW8
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q6AZW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRKTRNFKH KTVKDNKVLT EGSDQESEKD NSQCCDPATN ERVQAEKRQY
60 70 80 90 100
VCTECGKAFS QSANLTVHER IHTGEKPYKC KECGKAFSHS SNLVVHRRIH
110 120 130 140 150
TGLKPYTCSE CGKSFSGKSH LIRHQGIHSG EKTYECKECG KAFSRSSGLI
160 170 180 190 200
SHHRVHTGEK PYSCIECGKA FSRSSNLTQH QRMHRGKKVY KCKECGKTCG
210 220 230 240 250
SNTKIMDHQR IHTGEKPYEC DECGKTFILR KTLNEHQRLH RREKPYKCNE
260 270 280 290 300
CGKAFTSNRN LVDHQRVHTG EKPYKCNECG KTFRQTSQVI LHLRTHTKEK
310 320 330
PYKCSECGKA YRYSSQLIQH QRKHNEEKET S
Length:331
Mass (Da):38,270
Last modified:September 13, 2004 - v1
Checksum:i0F78D1090AA32CB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57K → N in BAC04303 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094189 mRNA Translation: BAC04303.1
BC075094 mRNA Translation: AAH75094.1
BC075095 mRNA Translation: AAH75095.1
BX538171 mRNA Translation: CAD98047.1
CCDSiCCDS2716.1
RefSeqiNP_775929.2, NM_173658.2
XP_005265147.1, XM_005265090.4
XP_006713180.1, XM_006713117.3
XP_011531924.1, XM_011533622.2
UniGeneiHs.733134

Genome annotation databases

EnsembliENST00000322734; ENSP00000324605; ENSG00000144792
ENST00000625494; ENSP00000487319; ENSG00000280661
GeneIDi285349
KEGGihsa:285349
UCSCiuc003cnl.2 human

Similar proteinsi

Entry informationi

Entry nameiZN660_HUMAN
AccessioniPrimary (citable) accession number: Q6AZW8
Secondary accession number(s): Q7Z331, Q8N9M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: September 13, 2004
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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