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UniProtKB - Q6AZJ8 (Q6AZJ8_XENLA)
Protein
Histone H2A
Gene
h2ac14.L
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- protein heterodimerization activity Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H2AUniRule annotation |
Gene namesi | ORF Names:XELAEV_18003602mgImported |
Organismi | Xenopus laevis (African clawed frog)Imported |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-994962, h2ac14.L |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Other locations
- Chromosome ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome coreUniRule annotationARBA annotation, NucleusUniRule annotationARBA annotationInteractioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
UniRule annotationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Protein-protein interaction databases
DIPi | DIP-38576N |
IntActi | Q6AZJ8, 3 interactors |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6AZJ8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 89 | HistoneInterPro annotationAdd BLAST | 85 | |
Domaini | 92 – 125 | Histone_H2A_CInterPro annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
OMAi | KWHAPGR |
OrthoDBi | 1504122at2759 |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
PANTHERi | PTHR23430, PTHR23430, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6AZJ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRGKQGGK TRAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV
60 70 80 90 100
YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAVRN DEELNKLLGR
110 120 130
VTIAQGGVLP NIQSVLLPKK TESSKSAKSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077816 mRNA Translation: AAH77816.1 KV471903 Genomic DNA Translation: OCT55815.1 |
RefSeqi | NP_001087948.1, NM_001094479.1 |
Genome annotation databases
GeneIDi | 494591 |
KEGGi | xla:494591 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC077816 mRNA Translation: AAH77816.1 KV471903 Genomic DNA Translation: OCT55815.1 |
RefSeqi | NP_001087948.1, NM_001094479.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KXB | X-ray | 3.20 | C/G | 2-130 | [»] | |
3LEL | X-ray | 2.95 | C/G/M/Q | 2-130 | [»] | |
3LZ0 | X-ray | 2.50 | C/G | 2-120 | [»] | |
3LZ1 | X-ray | 2.50 | C/G | 2-120 | [»] | |
3MGP | X-ray | 2.44 | C/G | 2-120 | [»] | |
3MGQ | X-ray | 2.65 | C/G | 2-120 | [»] | |
3MGR | X-ray | 2.30 | C/G | 2-120 | [»] | |
3MGS | X-ray | 3.15 | C/G | 2-120 | [»] | |
3MVD | X-ray | 2.90 | C/G | 2-130 | [»] | |
4KGC | X-ray | 2.69 | C/G | 1-130 | [»] | |
4KHA | X-ray | 2.35 | B | 15-103 | [»] | |
5Z3U | electron microscopy | 4.31 | C/G | 2-130 | [»] | |
5Z3V | electron microscopy | 4.22 | C/G | 2-130 | [»] | |
6ESF | electron microscopy | 3.70 | C/G | 2-130 | [»] | |
6ESG | electron microscopy | 5.40 | C/G | 2-130 | [»] | |
6ESH | electron microscopy | 5.10 | C/G | 2-130 | [»] | |
6ESI | electron microscopy | 6.30 | C/G | 2-130 | [»] | |
6J99 | electron microscopy | 4.10 | C/G | 1-130 | [»] | |
6JM9 | electron microscopy | 7.30 | C/G | 15-121 | [»] | |
6JMA | electron microscopy | 6.80 | C/G | 15-130 | [»] | |
6JYL | electron microscopy | 3.37 | C/G | 2-130 | [»] | |
6K01 | X-ray | 2.84 | C | 15-106 | [»] | |
6K1P | electron microscopy | 3.87 | C/G | 2-130 | [»] | |
6UGM | electron microscopy | 3.70 | C/G | 13-119 | [»] | |
6UH5 | electron microscopy | 3.50 | C/G | 13-119 | [»] | |
6Z6P | electron microscopy | 4.43 | C | 17-119 | [»] | |
7EA5 | electron microscopy | 3.30 | C/G | 14-118 | [»] | |
7KTQ | electron microscopy | 3.30 | C/G | 14-118 | [»] | |
7OH9 | electron microscopy | 3.00 | C/G | 2-130 | [»] | |
7OHA | electron microscopy | 2.90 | C/G | 2-130 | [»] | |
7OHB | electron microscopy | 3.40 | C/G | 2-130 | [»] | |
7OHC | electron microscopy | 2.50 | C/G | 2-130 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-38576N |
IntActi | Q6AZJ8, 3 interactors |
Protocols and materials databases
DNASUi | 494591 |
Genome annotation databases
GeneIDi | 494591 |
KEGGi | xla:494591 |
Organism-specific databases
CTDi | 494591 |
Xenbasei | XB-GENE-994962, h2ac14.L |
Phylogenomic databases
OMAi | KWHAPGR |
OrthoDBi | 1504122at2759 |
Miscellaneous databases
EvolutionaryTracei | Q6AZJ8 |
Family and domain databases
CDDi | cd00074, H2A, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR009072, Histone-fold IPR002119, Histone_H2A IPR007125, Histone_H2A/H2B/H3 IPR032454, Histone_H2A_C IPR032458, Histone_H2A_CS |
PANTHERi | PTHR23430, PTHR23430, 1 hit |
Pfami | View protein in Pfam PF00125, Histone, 1 hit PF16211, Histone_H2A_C, 1 hit |
PRINTSi | PR00620, HISTONEH2A |
SMARTi | View protein in SMART SM00414, H2A, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
PROSITEi | View protein in PROSITE PS00046, HISTONE_H2A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6AZJ8_XENLA | |
Accessioni | Q6AZJ8Primary (citable) accession number: Q6AZJ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 13, 2004 |
Last sequence update: | September 13, 2004 | |
Last modified: | January 19, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |