UniProtKB - Q6AZ54 (HEMGN_RAT)
Protein
Hemogen
Gene
Hemgn
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity).By similarity
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- regulation of osteoblast differentiation Source: RGD
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: HemogenAlternative name(s): Hemopoietic gene protein Protein RP59 |
Gene namesi | Name:Hemgn Synonyms:Rp59 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621569, Hemgn |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245363 | 1 – 514 | HemogenAdd BLAST | 514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 90 | PhosphoserineCombined sources | 1 | |
Modified residuei | 124 | PhosphoserineBy similarity | 1 | |
Modified residuei | 153 | PhosphoserineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 179 | PhosphoserineCombined sources | 1 | |
Modified residuei | 207 | PhosphoserineCombined sources | 1 | |
Modified residuei | 221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 259 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 277 | PhosphoserineBy similarity | 1 | |
Modified residuei | 305 | PhosphoserineBy similarity | 1 | |
Modified residuei | 322 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 415 | PhosphoserineCombined sources | 1 | |
Modified residuei | 422 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6AZ54 |
PRIDEi | Q6AZ54 |
PTM databases
iPTMneti | Q6AZ54 |
PhosphoSitePlusi | Q6AZ54 |
Expressioni
Tissue specificityi
Expressed by bone marrow cells and osteoblasts. Also expressed by ameloblasts in tooth enamel (at protein level). Expressed in enamel organ, ameloblasts, spleen, bone marrow cells and osteoblasts.3 Publications
Developmental stagei
At 9 dpc expressed in extraembryonic mesodermal layers with its prospective blood islands. Expressed in blood islands at day 12 dpc. Expressed by the intraembryonic primary ectoderm including the primitive streak at day 9 dpc. Expressed in the fetal liver and in circulating cells at 17 dpc, the liver expression disappear around birth (at protein level).1 Publication
Gene expression databases
Bgeei | ENSRNOG00000009436, Expressed in testis and 20 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q6AZ54, 1 interactor |
STRINGi | 10116.ENSRNOP00000042341 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 87 | Necessary for nuclear localizationBy similarityAdd BLAST | 81 |
Phylogenomic databases
eggNOGi | ENOG502SBFR, Eukaryota |
GeneTreei | ENSGT00390000004522 |
HOGENOMi | CLU_569802_0_0_1 |
InParanoidi | Q6AZ54 |
OMAi | VYSYVLF |
OrthoDBi | 801077at2759 |
PhylomeDBi | Q6AZ54 |
TreeFami | TF338654 |
Family and domain databases
InterProi | View protein in InterPro IPR033272, Hemogen |
PANTHERi | PTHR15993, PTHR15993, 2 hits |
i Sequence
Sequence statusi: Complete.
Q6AZ54-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVRKDQSHL TLNQTPEAHV EKSHAPDIIG SWSLRNREQL KKRKAEAQGR
60 70 80 90 100
QTSQWQLGEQ KKRKYQRTGK GNRRGRKRQG NVEQKAESWS QTENERVQEV
110 120 130 140 150
LVPAEEETEY SGNTATQALP LRASPTKAVP TEHCSEVPQE SLQCQEITIQ
160 170 180 190 200
NHSQTHQRRD KAEALSPTTC QEIGVLQYSP KMCQDMAEPE ARSPKMCQET
210 220 230 240 250
AVPQTYSPKA HEDMAEYEAL SPKMCRETPV PQYHSSKIPQ DMTGPEALAP
260 270 280 290 300
DMCQETTVSQ NHSSKVPQDM AGPEALSLKM CQEPTVLQEH TLKICQDVAR
310 320 330 340 350
PDVLSSKTHQ EMTVPKALPC ITPGDAAGPE GCSPKTLPQS DVTPMSVTPG
360 370 380 390 400
KNTSHPDLGT AVAEGCFSEA GECIVSEDIS TKTHQEAVEP KFLSHKTYKE
410 420 430 440 450
FTVPIVSSHK TIQESPGPEE YSPGSRHEMS GPEDLSIKTC KNRDGPKHSL
460 470 480 490 500
PEGAQEVGGA QRQDPDAQDI EDAGAFSQDL EEGNKADQDP ETPAGPQGPQ
510
KICPENDVHS SALF
Sequence cautioni
The sequence CAC16090 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 431 | G → E in CAC16090 (PubMed:11161722).Curated | 1 | |
Sequence conflicti | 503 | C → F in CAC16090 (PubMed:11161722).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302650 mRNA Translation: CAC16090.1 Sequence problems. BC078739 mRNA Translation: AAH78739.1 |
RefSeqi | NP_579828.1, NM_133294.1 XP_008761915.1, XM_008763693.2 XP_008761916.1, XM_008763694.2 XP_017448603.1, XM_017593114.1 |
Genome annotation databases
Ensembli | ENSRNOT00000042649; ENSRNOP00000042341; ENSRNOG00000009436 |
GeneIDi | 113882 |
KEGGi | rno:113882 |
UCSCi | RGD:621569, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302650 mRNA Translation: CAC16090.1 Sequence problems. BC078739 mRNA Translation: AAH78739.1 |
RefSeqi | NP_579828.1, NM_133294.1 XP_008761915.1, XM_008763693.2 XP_008761916.1, XM_008763694.2 XP_017448603.1, XM_017593114.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q6AZ54, 1 interactor |
STRINGi | 10116.ENSRNOP00000042341 |
PTM databases
iPTMneti | Q6AZ54 |
PhosphoSitePlusi | Q6AZ54 |
Proteomic databases
PaxDbi | Q6AZ54 |
PRIDEi | Q6AZ54 |
Genome annotation databases
Ensembli | ENSRNOT00000042649; ENSRNOP00000042341; ENSRNOG00000009436 |
GeneIDi | 113882 |
KEGGi | rno:113882 |
UCSCi | RGD:621569, rat |
Organism-specific databases
CTDi | 55363 |
RGDi | 621569, Hemgn |
Phylogenomic databases
eggNOGi | ENOG502SBFR, Eukaryota |
GeneTreei | ENSGT00390000004522 |
HOGENOMi | CLU_569802_0_0_1 |
InParanoidi | Q6AZ54 |
OMAi | VYSYVLF |
OrthoDBi | 801077at2759 |
PhylomeDBi | Q6AZ54 |
TreeFami | TF338654 |
Miscellaneous databases
PROi | PR:Q6AZ54 |
Gene expression databases
Bgeei | ENSRNOG00000009436, Expressed in testis and 20 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR033272, Hemogen |
PANTHERi | PTHR15993, PTHR15993, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HEMGN_RAT | |
Accessioni | Q6AZ54Primary (citable) accession number: Q6AZ54 Secondary accession number(s): Q9ER23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | September 13, 2004 | |
Last modified: | August 12, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |