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Entry version 111 (07 Oct 2020)
Sequence version 2 (11 Sep 2007)
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Protein

Outer dense fiber protein 2

Gene

Odf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259, Loss of Nlp from mitotic centrosomes
R-RNO-380270, Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320, Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912, Anchoring of the basal body to the plasma membrane
R-RNO-8854518, AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Outer dense fiber protein 2
Alternative name(s):
84 kDa outer dense fiber protein
Cenexin
Outer dense fiber of sperm tails protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Odf2
Synonyms:Odf84
ORF Names:KKT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
3229, Odf2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994601 – 825Outer dense fiber protein 2Add BLAST825

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei87PhosphothreonineCombined sources1
Modified residuei90Phosphoserine; by TSSK4By similarity1
Modified residuei101PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei105PhosphothreonineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei134PhosphoserineCombined sources1
Modified residuei226PhosphothreonineBy similarity1
Modified residuei256PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Isoform 3 (identifier: Q6AYX5-3)
Modified residuei22PhosphoserineCombined sources1
Modified residuei37PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated. Phosphorylated on Ser-90 by TSSK4.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6AYX5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6AYX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6AYX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis-specific (PubMed:9045620). Expressed in the proximal compartment of the elongated spermatid tail; later expression progresses to the distal spermatid tail compartment located in the lumen of the seminiferous epithelium (PubMed:9698445). In spermatids (stages II-III) expression of the tails peaks and remains strong during the remaining steps of spermiogenesis (at protein level) (PubMed:9698445). Expression correlates with the onset of spermatogenesis and is first detected at 30 days. Higher expression is seen in testis of 40-day-old and adults that are older than 50 days (PubMed:9092585). No expression is seen in 10- and 20-day-old testes (PubMed:9092585).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000014584, Expressed in testis and 22 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6AYX5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6AYX5, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Self-associates. Associates with microtubules and forms a fibrillar structure partially linked to the microtubule network.

Interacts through its C-terminus with PLK1.

Interacts with ODF1 (PubMed:9045620).

Interacts with MARK4; the interaction is required for localization of ODF2 to centrioles (By similarity).

Interacts with TSSK4 (By similarity).

Interacts with AKNA (By similarity).

Interacts with QRICH2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000041336

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6AYX5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili139 – 212Sequence analysisAdd BLAST74
Coiled coili240 – 418Sequence analysisAdd BLAST179
Coiled coili456 – 793Sequence analysisAdd BLAST338

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ODF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUXQ, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00530000063497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_018326_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6AYX5

KEGG Orthology (KO)

More...
KOi
K16479

Identification of Orthologs from Complete Genome Data

More...
OMAi
KASYTNV

Database of Orthologous Groups

More...
OrthoDBi
328077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6AYX5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026099, Odf2-rel

The PANTHER Classification System

More...
PANTHERi
PTHR23162, PTHR23162, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6AYX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDRSSTPPL HVHVDENTPV HVHIKKLPKP SAASSQKSHK RGMKGDTVNV
60 70 80 90 100
RRSVRVKTKV PWMPPGKSSA RHVGCKWENP PHCLEITPPS SEKLVSVMRL
110 120 130 140 150
SDLSTEDDDS GHCKMNRYDK KIDSLMNAVG CLKSEVKMQK GERQMAKRFL
160 170 180 190 200
EERKEELEEV AHELAETEHE NTVLRHNIER IKEEKDFTML QKKHLQQEKE
210 220 230 240 250
CLMSKLVEAE MDGAAAAKQV MALKDTIGKL KTEKQMTCTD INTLTRQKEL
260 270 280 290 300
LLQKLSTFEE TNRTLRDLLR EQHCKEDSER LMEQQGALLK RLAEADSEKA
310 320 330 340 350
RLLLLLQDKD KEVEELLQEI QCEKAQAKTA SELSKSMESM RGHLQAQLRC
360 370 380 390 400
KEAENSRLCM QIKNLERSGN QHKAEVEAIM EQLKELKQKG DRDKETLKKA
410 420 430 440 450
IRAQKERAEK SEEYAEQLHV QLADKDLYVA EALSTLESWR SRYNQVVKDK
460 470 480 490 500
GDLELEIIVL NDRVTDLVNQ QQSLEEKMRE DRDSLVERLH RQTAEYSAFK
510 520 530 540 550
LENERLKASF APMEDKLNQA HLEVQQLKAS VKNYEGMIDN YKSQVMKTRL
560 570 580 590 600
EADEVAAQLE RCDKENKMLK DEMNKEIEAA RRQFQSQLAD LQQLPDILKI
610 620 630 640 650
TEAKLAECQD QLQGYERKNI DLTAIISDLR SRIEHQGDKL ELAREKHQAS
660 670 680 690 700
QKENKQLSQK VDELERKLEA TSTQNVEFLQ VIAKREEAIH QAQLRLEEKT
710 720 730 740 750
RECGSLARQL ESAIEDARRQ VEQTKEQALS KERAAQSKIL DLETQLSRTK
760 770 780 790 800
TELGQLRRTR DDVDRRYQSR LQDLKDRLEQ SESTNRSMQN YVQFLKSSYA
810 820
NVFGDGPYTS SYLTSSPIRS RSPPA
Length:825
Mass (Da):95,440
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF1490FF9F96CEC7
GO
Isoform 2 (identifier: Q6AYX5-2) [UniParc]FASTAAdd to basket
Also known as: Cenexin 2

The sequence of this isoform differs from the canonical sequence as follows:
     763-769: VDRRYQS → ENQKCWK
     770-825: Missing.

Show »
Length:769
Mass (Da):89,095
Checksum:iEF6EFE3003F8365D
GO
Isoform 3 (identifier: Q6AYX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MKDRSSTPPL...LPKPSAASSQ → MSASSSGGSP...PCGAPSVTVT
     60-78: Missing.
     633-652: IEHQGDKLELAREKHQASQK → VRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:638
Mass (Da):73,359
Checksum:iC3DAA2F22ACA0A34
GO
Isoform 4 (identifier: Q6AYX5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     60-78: Missing.
     633-652: IEHQGDKLELAREKHQASQK → VRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:591
Mass (Da):68,600
Checksum:i32B0FBFF3EC3DA40
GO
Isoform 5 (identifier: Q6AYX5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     60-78: Missing.
     276-276: E → ELCLKVPECARQHRPGRERQEDCQ
     630-652: RSRIEHQGDKLELAREKHQASQK → HSRVRDWQKGSHELARAGARLPR
     653-825: Missing.

Show »
Length:614
Mass (Da):71,315
Checksum:i291E30388CB3CEEE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7X0G3V7X0_RAT
Outer dense fiber of sperm tails 2,...
Odf2 rCG_45844
705Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0H2UHM4A0A0H2UHM4_RAT
Outer dense fiber protein 2
Odf2
811Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA64567 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46D → Y in AAC53134 (PubMed:9092585).Curated1
Sequence conflicti107 – 108DD → EE in CAA64567 (PubMed:9369191).Curated2
Sequence conflicti120K → E in AAC53134 (PubMed:9092585).Curated1
Sequence conflicti483D → H in AAC53134 (PubMed:9092585).Curated1
Sequence conflicti511A → P in AAC08408 (PubMed:9698445).Curated1
Sequence conflicti543S → T in CAA64567 (PubMed:9369191).Curated1
Isoform 3 (identifier: Q6AYX5-3)
Sequence conflicti25Q → E in AAC08408 (PubMed:9698445).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0276771 – 42Missing in isoform 4 and isoform 5. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_0276781 – 36MKDRS…AASSQ → MSASSSGGSPRFPSCGKNGV TSLTQKKVLRTPCGAPSVTV T in isoform 3. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_02767960 – 78Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_027680276E → ELCLKVPECARQHRPGRERQ EDCQ in isoform 5. 1 Publication1
Alternative sequenceiVSP_027681630 – 652RSRIE…QASQK → HSRVRDWQKGSHELARAGAR LPR in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_027682633 – 652IEHQG…QASQK → VRDWQKGSHELARAGARLPR in isoform 3 and isoform 4. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_027683653 – 825Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST173
Alternative sequenceiVSP_027684763 – 769VDRRYQS → ENQKCWK in isoform 2. 1 Publication7
Alternative sequenceiVSP_027685770 – 825Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X95272 mRNA Translation: CAA64567.1 Frameshift.
U62821 mRNA Translation: AAC53134.1
AF053971 mRNA Translation: AAC08408.1
AF162756 mRNA Translation: AAF80473.2
AABR03024548 Genomic DNA No translation available.
BC078857 mRNA Translation: AAH78857.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138477.1, NM_001145005.1
NP_058909.2, NM_017213.2 [Q6AYX5-3]
XP_017447024.1, XM_017591535.1 [Q6AYX5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000040457; ENSRNOP00000049041; ENSRNOG00000014584 [Q6AYX5-3]
ENSRNOT00000041921; ENSRNOP00000041336; ENSRNOG00000014584 [Q6AYX5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29479

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:29479

UCSC genome browser

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UCSCi
RGD:3229, rat [Q6AYX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95272 mRNA Translation: CAA64567.1 Frameshift.
U62821 mRNA Translation: AAC53134.1
AF053971 mRNA Translation: AAC08408.1
AF162756 mRNA Translation: AAF80473.2
AABR03024548 Genomic DNA No translation available.
BC078857 mRNA Translation: AAH78857.1
RefSeqiNP_001138477.1, NM_001145005.1
NP_058909.2, NM_017213.2 [Q6AYX5-3]
XP_017447024.1, XM_017591535.1 [Q6AYX5-1]

3D structure databases

SMRiQ6AYX5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000041336

PTM databases

iPTMnetiQ6AYX5
PhosphoSitePlusiQ6AYX5

Proteomic databases

PaxDbiQ6AYX5

Genome annotation databases

EnsembliENSRNOT00000040457; ENSRNOP00000049041; ENSRNOG00000014584 [Q6AYX5-3]
ENSRNOT00000041921; ENSRNOP00000041336; ENSRNOG00000014584 [Q6AYX5-1]
GeneIDi29479
KEGGirno:29479
UCSCiRGD:3229, rat [Q6AYX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4957
RGDi3229, Odf2

Phylogenomic databases

eggNOGiENOG502QUXQ, Eukaryota
GeneTreeiENSGT00530000063497
HOGENOMiCLU_018326_0_0_1
InParanoidiQ6AYX5
KOiK16479
OMAiKASYTNV
OrthoDBi328077at2759
PhylomeDBiQ6AYX5

Enzyme and pathway databases

ReactomeiR-RNO-2565942, Regulation of PLK1 Activity at G2/M Transition
R-RNO-380259, Loss of Nlp from mitotic centrosomes
R-RNO-380270, Recruitment of mitotic centrosome proteins and complexes
R-RNO-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-RNO-380320, Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912, Anchoring of the basal body to the plasma membrane
R-RNO-8854518, AURKA Activation by TPX2

Miscellaneous databases

Protein Ontology

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PROi
PR:Q6AYX5

Gene expression databases

BgeeiENSRNOG00000014584, Expressed in testis and 22 other tissues
ExpressionAtlasiQ6AYX5, baseline and differential
GenevisibleiQ6AYX5, RN

Family and domain databases

InterProiView protein in InterPro
IPR026099, Odf2-rel
PANTHERiPTHR23162, PTHR23162, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiODFP2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6AYX5
Secondary accession number(s): O70408
, P97575, Q62693, Q9JIZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 7, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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