Abhd12

Functionⁱ

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityⁱ

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	246	NucleophileBy similarity	1
Active siteⁱ	333	Charge relay systemBy similarity	1
Active siteⁱ	372	Charge relay systemBy similarity	1

GO - Molecular functionⁱ

acylglycerol lipase activity Source: UniProtKB
lysophospholipase activity Source: Ensembl
palmitoyl-(protein) hydrolase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acylglycerol catabolic process Source: UniProtKB
adult walking behavior Source: Ensembl
monoacylglycerol catabolic process Source: Ensembl
phosphatidylserine catabolic process Source: Ensembl
protein depalmitoylation Source: Ensembl
response to auditory stimulus Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

Reactomeⁱ	R-RNO-426048 Arachidonate production from DAG

Reactomeⁱ

R-RNO-426048 Arachidonate production from DAG

Protein family/group databases

ESTHERⁱ	ratno-q6ayt7 ABHD12-PHARC

ESTHERⁱ

ratno-q6ayt7 ABHD12-PHARC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity) Alternative name(s): 2-arachidonoylglycerol hydrolaseCurated Abhydrolase domain-containing protein 12Curated
Gene namesⁱ	Name:Abhd12Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1562570 Abhd12

RGDⁱ

1562570 Abhd12

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 74	CytoplasmicBy similarityAdd BLAST	74
Transmembraneⁱ	75 – 95	HelicalBy similarityAdd BLAST	21
Topological domainⁱ	96 – 398	ExtracellularBy similarityAdd BLAST	303

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3708071

ChEMBLⁱ

CHEMBL3708071

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000375809	1 – 398	Monoacylglycerol lipase ABHD12Add BLAST		398

Post-translational modificationⁱ

Glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q6AYT7
PRIDEⁱ	Q6AYT7

PTM databases

iPTMnetⁱ	Q6AYT7
PhosphoSitePlusⁱ	Q6AYT7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000036934 Expressed in 10 organ(s), highest expression level in brain
Genevisibleⁱ	Q6AYT7 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010640

STRINGⁱ

10116.ENSRNOP00000010640

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6AYT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	18 – 25	Poly-Ser		8
Compositional biasⁱ	26 – 29	Poly-Ala		4

Sequence similaritiesⁱ

Belongs to the serine esterase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1552 Eukaryota COG1073 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006625
HOGENOMⁱ	HOG000230822
InParanoidⁱ	Q6AYT7
KEGG Orthology (KO) More...KOⁱ	K13704
OMAⁱ	WGPVEFH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QYO
PhylomeDBⁱ	Q6AYT7
TreeFamⁱ	TF315122

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR026605 ABHD12 IPR022742 Hydrolase_4
PANTHERⁱ	PTHR12277:SF61 PTHR12277:SF61, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12146 Hydrolase_4, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6AYT7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP 
        60         70         80         90        100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL 
       110        120        130        140        150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK 
       160        170        180        190        200
NAQGKDQMWY EDALASNHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV 
       210        220        230        240        250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG 
       260        270        280        290        300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF 
       310        320        330        340        350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP 
       360        370        380        390 
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH

Length:398

Mass (Da):45,296

Last modified:September 13, 2004 - v1

Checksum:ⁱB15C464EE3CBAFB0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474050 Genomic DNA Translation: EDL86136.1 BC078918 mRNA Translation: AAH78918.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001019485.1, NM_001024314.1
UniGeneⁱ	Rn.128955

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934
GeneIDⁱ	499913
KEGGⁱ	rno:499913
UCSC genome browser More...UCSCⁱ	RGD:1562570 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6AYT7	Monoacylglycerol lipase ABHD12		MOUSE		398	UniRef90_Q99LR1
Monoacylglycerol lipase ABHD12		BOVIN		398
Monoacylglycerol lipase ABHD12		HUMAN		398
Monoacylglycerol lipase ABHD12		MACFA		398
monoacylglycerol lipase ABHD12 isoform X5		DELLE		405
+96

Protein	Similar proteins		Species	Score	Length	Source
Q6AYT7	Monoacylglycerol lipase ABHD12		MOUSE		398	UniRef50_Q99LR1
Monoacylglycerol lipase ABHD12		MACFA		398
Monoacylglycerol lipase ABHD12		BOVIN		398
Monoacylglycerol lipase ABHD12		HUMAN		398
Monoacylglycerol lipase ABHD12		XENTR		386
+152

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH474050 Genomic DNA Translation: EDL86136.1 BC078918 mRNA Translation: AAH78918.1
RefSeqⁱ	NP_001019485.1, NM_001024314.1
UniGeneⁱ	Rn.128955

3D structure databases

ProteinModelPortalⁱ	Q6AYT7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010640

STRINGⁱ

10116.ENSRNOP00000010640

Chemistry databases

ChEMBLⁱ	CHEMBL3708071

ChEMBLⁱ

CHEMBL3708071

Protein family/group databases

ESTHERⁱ	ratno-q6ayt7 ABHD12-PHARC

ESTHERⁱ

ratno-q6ayt7 ABHD12-PHARC

PTM databases

iPTMnetⁱ	Q6AYT7
PhosphoSitePlusⁱ	Q6AYT7

Proteomic databases

PaxDbⁱ	Q6AYT7
PRIDEⁱ	Q6AYT7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934
GeneIDⁱ	499913
KEGGⁱ	rno:499913
UCSCⁱ	RGD:1562570 rat

Organism-specific databases

CTDⁱ	26090
RGDⁱ	1562570 Abhd12

Phylogenomic databases

eggNOGⁱ	KOG1552 Eukaryota COG1073 LUCA
GeneTreeⁱ	ENSGT00390000006625
HOGENOMⁱ	HOG000230822
InParanoidⁱ	Q6AYT7
KOⁱ	K13704
OMAⁱ	WGPVEFH
OrthoDBⁱ	EOG091G0QYO
PhylomeDBⁱ	Q6AYT7
TreeFamⁱ	TF315122

Enzyme and pathway databases

Reactomeⁱ	R-RNO-426048 Arachidonate production from DAG

Reactomeⁱ

R-RNO-426048 Arachidonate production from DAG

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6AYT7

PROⁱ

PR:Q6AYT7

Gene expression databases

Bgeeⁱ	ENSRNOG00000036934 Expressed in 10 organ(s), highest expression level in brain
Genevisibleⁱ	Q6AYT7 RN

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR026605 ABHD12 IPR022742 Hydrolase_4
PANTHERⁱ	PTHR12277:SF61 PTHR12277:SF61, 1 hit
Pfamⁱ	View protein in Pfam PF12146 Hydrolase_4, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ABD12_RAT
Accessionⁱ	Q6AYT7Primary (citable) accession number: Q6AYT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
	Last sequence update:	September 13, 2004
	Last modified:	September 12, 2018
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q6AYT7 (ABD12_RAT)

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Monoacylglycerol lipase ABHD12

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ