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Protein

Monoacylglycerol lipase ABHD12

Gene

Abhd12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246NucleophileBy similarity1
Active sitei333Charge relay systemBy similarity1
Active sitei372Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-RNO-426048 Arachidonate production from DAG

Protein family/group databases

ESTHERiratno-q6ayt7 ABHD12-PHARC

Names & Taxonomyi

Protein namesi
Recommended name:
Monoacylglycerol lipase ABHD12Curated (EC:3.1.1.23By similarity)
Alternative name(s):
2-arachidonoylglycerol hydrolaseCurated
Abhydrolase domain-containing protein 12Curated
Gene namesi
Name:Abhd12Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1562570 Abhd12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicBy similarityAdd BLAST74
Transmembranei75 – 95HelicalBy similarityAdd BLAST21
Topological domaini96 – 398ExtracellularBy similarityAdd BLAST303

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3708071

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003758091 – 398Monoacylglycerol lipase ABHD12Add BLAST398

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6AYT7
PRIDEiQ6AYT7

PTM databases

iPTMnetiQ6AYT7
PhosphoSitePlusiQ6AYT7

Expressioni

Gene expression databases

BgeeiENSRNOG00000036934 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ6AYT7 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010640

Structurei

3D structure databases

ProteinModelPortaliQ6AYT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Ser8
Compositional biasi26 – 29Poly-Ala4

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1552 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000006625
HOGENOMiHOG000230822
InParanoidiQ6AYT7
KOiK13704
OMAiWGPVEFH
OrthoDBiEOG091G0QYO
PhylomeDBiQ6AYT7
TreeFamiTF315122

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR026605 ABHD12
IPR022742 Hydrolase_4
PANTHERiPTHR12277:SF61 PTHR12277:SF61, 1 hit
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP
60 70 80 90 100
HSASDAGMKR ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL
110 120 130 140 150
IFLNFVRVPY FIDLKKPQDQ GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK
160 170 180 190 200
NAQGKDQMWY EDALASNHPI ILYLHGNAGT RGGDHRVELY KVLSSLGYHV
210 220 230 240 250
VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV YIWGHSLGTG
260 270 280 290 300
VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
310 320 330 340 350
FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP
360 370 380 390
SRSFRDFKVQ FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH
Length:398
Mass (Da):45,296
Last modified:September 13, 2004 - v1
Checksum:iB15C464EE3CBAFB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA Translation: EDL86136.1
BC078918 mRNA Translation: AAH78918.1
RefSeqiNP_001019485.1, NM_001024314.1
UniGeneiRn.128955

Genome annotation databases

EnsembliENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934
GeneIDi499913
KEGGirno:499913
UCSCiRGD:1562570 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474050 Genomic DNA Translation: EDL86136.1
BC078918 mRNA Translation: AAH78918.1
RefSeqiNP_001019485.1, NM_001024314.1
UniGeneiRn.128955

3D structure databases

ProteinModelPortaliQ6AYT7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010640

Chemistry databases

ChEMBLiCHEMBL3708071

Protein family/group databases

ESTHERiratno-q6ayt7 ABHD12-PHARC

PTM databases

iPTMnetiQ6AYT7
PhosphoSitePlusiQ6AYT7

Proteomic databases

PaxDbiQ6AYT7
PRIDEiQ6AYT7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010641; ENSRNOP00000010640; ENSRNOG00000036934
GeneIDi499913
KEGGirno:499913
UCSCiRGD:1562570 rat

Organism-specific databases

CTDi26090
RGDi1562570 Abhd12

Phylogenomic databases

eggNOGiKOG1552 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00390000006625
HOGENOMiHOG000230822
InParanoidiQ6AYT7
KOiK13704
OMAiWGPVEFH
OrthoDBiEOG091G0QYO
PhylomeDBiQ6AYT7
TreeFamiTF315122

Enzyme and pathway databases

ReactomeiR-RNO-426048 Arachidonate production from DAG

Miscellaneous databases

PROiPR:Q6AYT7

Gene expression databases

BgeeiENSRNOG00000036934 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ6AYT7 RN

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR026605 ABHD12
IPR022742 Hydrolase_4
PANTHERiPTHR12277:SF61 PTHR12277:SF61, 1 hit
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABD12_RAT
AccessioniPrimary (citable) accession number: Q6AYT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 13, 2004
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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