UniProtKB - Q6AYP2 (MFA3L_RAT)
Protein
Microfibrillar-associated protein 3-like
Gene
Mfap3l
Organism
Rattus norvegicus (Rat)
Status
Functioni
May participate in the nuclear signaling of EGFR and MAPK1/ERK2.By similarity
Caution
A protein kinase activity has been reported kinase activity however PROSITE, Pfam do not detect a protein kinase domain. Its enzyme activity is therefore unsure.By similarity
Names & Taxonomyi
Protein namesi | Recommended name: Microfibrillar-associated protein 3-like |
Gene namesi | Name:Mfap3l |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311274, Mfap3l |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Other locations
- Cytoplasm By similarity
Note: Mainly localized in the nucleus.By similarity
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cell junction Source: Ensembl
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 148 | ExtracellularSequence analysisAdd BLAST | 120 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 409 | CytoplasmicSequence analysisAdd BLAST | 240 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000014871 | 29 – 409 | Microfibrillar-associated protein 3-likeAdd BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 67 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 68 ↔ 125 | PROSITE-ProRule annotation | ||
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 287 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 298 | PhosphoserineCombined sources | 1 | |
Modified residuei | 303 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q6AYP2 |
PRIDEi | Q6AYP2 |
PTM databases
GlyGeni | Q6AYP2, 5 sites |
iPTMneti | Q6AYP2 |
PhosphoSitePlusi | Q6AYP2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011775, Expressed in testis and 20 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 141 | Ig-like C2-typeAdd BLAST | 95 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_2_0_1 |
InParanoidi | Q6AYP2 |
OMAi | GQNFVRQ |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q6AYP2 |
TreeFami | TF333205 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6AYP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLLKSHLTV CLPPSVPFLI LVSTLATAKS VTNSTLNGTD VVLGSVPVII
60 70 80 90 100
ARTDHIIVKE GNSALINCSA FGIPDLEYKW YNSVGKLLKE MDDEKERGGG
110 120 130 140 150
KWQMLDGGLL NITKVSFSDR GKYTCVASNI YGTINNTVTL RVIFTSGDMG
160 170 180 190 200
VYYMVVCLVA FTIVMILNIT RLCMMSSHLK KTEKAINEFF RTEGAEKLQK
210 220 230 240 250
AFEIAKRIPI ITSAKTLELA KVTQFKTMEF ARYIEELARS VPLPPLIMNC
260 270 280 290 300
RTIMEEIMEV VGLEEQGQNF VRHTPEGQEA PDRDEVYTIP NSLKRSESPT
310 320 330 340 350
ADSDASSLHE QPQQIAIKVS VHPQSKKDHV DDQEGENLEV KDEEETEPSE
360 370 380 390 400
EHSPETAEPS TDITTTELTS EEASPVEAPE RELPPAHLET TEPAVTCDRN
TCIIYESHV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078969 mRNA Translation: AAH78969.1 |
RefSeqi | NP_001012049.1, NM_001012049.1 XP_017455596.1, XM_017600107.1 |
Genome annotation databases
Ensembli | ENSRNOT00000015759; ENSRNOP00000015759; ENSRNOG00000011775 |
GeneIDi | 306424 |
KEGGi | rno:306424 |
UCSCi | RGD:1311274, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC078969 mRNA Translation: AAH78969.1 |
RefSeqi | NP_001012049.1, NM_001012049.1 XP_017455596.1, XM_017600107.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000015759 |
PTM databases
GlyGeni | Q6AYP2, 5 sites |
iPTMneti | Q6AYP2 |
PhosphoSitePlusi | Q6AYP2 |
Proteomic databases
PaxDbi | Q6AYP2 |
PRIDEi | Q6AYP2 |
Genome annotation databases
Ensembli | ENSRNOT00000015759; ENSRNOP00000015759; ENSRNOG00000011775 |
GeneIDi | 306424 |
KEGGi | rno:306424 |
UCSCi | RGD:1311274, rat |
Organism-specific databases
CTDi | 9848 |
RGDi | 1311274, Mfap3l |
Phylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_2_0_1 |
InParanoidi | Q6AYP2 |
OMAi | GQNFVRQ |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q6AYP2 |
TreeFami | TF333205 |
Miscellaneous databases
PROi | PR:Q6AYP2 |
Gene expression databases
Bgeei | ENSRNOG00000011775, Expressed in testis and 20 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFA3L_RAT | |
Accessioni | Q6AYP2Primary (citable) accession number: Q6AYP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | August 12, 2020 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |