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Protein

Apoptosis facilitator Bcl-2-like protein 14

Gene

Bcl2l14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apoptosis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis facilitator Bcl-2-like protein 14
Short name:
Bcl2-L-14
Gene namesi
Name:Bcl2l14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1562777 Bcl2l14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430771 – 326Apoptosis facilitator Bcl-2-like protein 14Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6AYK4
PRIDEiQ6AYK4

PTM databases

iPTMnetiQ6AYK4
PhosphoSitePlusiQ6AYK4

Expressioni

Gene expression databases

BgeeiENSRNOG00000028632 Expressed in 8 organ(s), highest expression level in testis
GenevisibleiQ6AYK4 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029468

Structurei

3D structure databases

ProteinModelPortaliQ6AYK4
SMRiQ6AYK4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi211 – 225BH3Add BLAST15
Motifi307 – 314BH28

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00390000007293
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ6AYK4
OMAiNFSPWVQ
OrthoDBiEOG091G0BS5
PhylomeDBiQ6AYK4
TreeFamiTF336214

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSTSVYDLE DIPLEDDDPN SIEFKILAFY ARHHVFKSTP AVFSPKLSRT
60 70 80 90 100
RSLSQKALGT WSTDSWTQIS LPCRDSLSSE KHISLGKKKS SWRTLFRVTE
110 120 130 140 150
KEEEPPSSPK EIHAQGPFPV ERQGRNQHWS RSLSSVEQCL ESEAVDSKVA
160 170 180 190 200
CIANRVAEIV YSWPPPDDSQ SQGGGKFKES VPKILHFELQ GPQLRPCDSK
210 220 230 240 250
KDGEDQIINR IVELLKYSGD QLGREIKRDK ALVSIFQEGL SYSVFRTITD
260 270 280 290 300
LFLRDVDTRG ESEIKAQGFK AALAIDAIAK LTAIDNHPMN RMLGFGTKYL
310 320
REYFSPWVQQ NGGWEKILGL SHEEVD
Length:326
Mass (Da):36,891
Last modified:September 13, 2004 - v1
Checksum:iEE4235D7A1EC27B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079010 mRNA Translation: AAH79010.1
RefSeqiNP_001019509.1, NM_001024338.1
XP_006237595.1, XM_006237533.2
XP_006237596.1, XM_006237534.3
XP_008761638.1, XM_008763416.2
XP_017448325.1, XM_017592836.1
UniGeneiRn.162775

Genome annotation databases

EnsembliENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632
GeneIDi500348
KEGGirno:500348
UCSCiRGD:1562777 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079010 mRNA Translation: AAH79010.1
RefSeqiNP_001019509.1, NM_001024338.1
XP_006237595.1, XM_006237533.2
XP_006237596.1, XM_006237534.3
XP_008761638.1, XM_008763416.2
XP_017448325.1, XM_017592836.1
UniGeneiRn.162775

3D structure databases

ProteinModelPortaliQ6AYK4
SMRiQ6AYK4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029468

PTM databases

iPTMnetiQ6AYK4
PhosphoSitePlusiQ6AYK4

Proteomic databases

PaxDbiQ6AYK4
PRIDEiQ6AYK4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032229; ENSRNOP00000029468; ENSRNOG00000028632
GeneIDi500348
KEGGirno:500348
UCSCiRGD:1562777 rat

Organism-specific databases

CTDi79370
RGDi1562777 Bcl2l14

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
GeneTreeiENSGT00390000007293
HOGENOMiHOG000013215
HOVERGENiHBG050649
InParanoidiQ6AYK4
OMAiNFSPWVQ
OrthoDBiEOG091G0BS5
PhylomeDBiQ6AYK4
TreeFamiTF336214

Miscellaneous databases

PROiPR:Q6AYK4

Gene expression databases

BgeeiENSRNOG00000028632 Expressed in 8 organ(s), highest expression level in testis
GenevisibleiQ6AYK4 RN

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR033229 BCL2L14
IPR036834 Blc2-like_sf
PANTHERiPTHR14965:SF1 PTHR14965:SF1, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2L14_RAT
AccessioniPrimary (citable) accession number: Q6AYK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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