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Protein
Submitted name:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 5

Gene

Ddx5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3899300 SUMOylation of transcription cofactors
R-RNO-72163 mRNA Splicing - Major Pathway
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Submitted name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5Imported
Submitted name:
DEAD-box helicase 5Imported
Submitted name:
Ddx5Imported
Gene namesi
Name:Ddx5Imported
ORF Names:rCG_35034Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619906 Ddx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ6AYI1

Expressioni

Gene expression databases

BgeeiENSRNOG00000030680 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Runx2Q087752EBI-931635,EBI-903354From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6AYI1, 5 interactors
STRINGi10116.ENSRNOP00000041663

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 122Q_MOTIFInterPro annotationAdd BLAST29
Domaini125 – 300Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini328 – 475Helicase C-terminalInterPro annotationAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili323 – 343Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 122Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0331 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00920000149008
HOGENOMiHOG000268804
HOVERGENiHBG015893
KOiK12823
OMAiANMHNGM
OrthoDBiEOG091G033A
TreeFamiTF300332

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR033488 DDX5
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR012587 P68_rpt
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF404 PTHR24031:SF404, 1 hit
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
PF08061 P68HR, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM01414 P68HR, 2 hits
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q6AYI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYSSDRDR GRDRGFGAPR FGGSRTGPLS GKKFGNPGEK LVKKKWNLDE
60 70 80 90 100
LPKFEKNFYQ EHPDLARRTA QEVDTYRRSK EITVRGHNCP KPVLNFYEAN
110 120 130 140 150
FPANVMDVIA RQNFTEPTAI QAQGWPVALS GLDMVGVAQT GSGKTLSYLL
160 170 180 190 200
PAIVHINHQP FLERGDGPIC LVLAPTRELA QQVQQVAAEY CRACRLKSTC
210 220 230 240 250
IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR RTTYLVLDEA
260 270 280 290 300
DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI
310 320 330 340 350
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET
360 370 380 390 400
KRRCDELTRK MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV
410 420 430 440 450
ASRGLDVEDV KFVINYDYPN SSEDYIHRIG RTARSTKTGT AYTFFTPNNI
460 470 480 490 500
KQVSDLISVL REANQAINPK LLQLVEDRGS GRSRGRGGMK DDRRDRYSAG
510 520 530 540 550
KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY TNGSFGSNFV
560 570 580 590 600
SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VANMHNGMNQ QAYAYPATAA
610
AAPMIGYPMP TGYSQ
Length:615
Mass (Da):69,239
Last modified:September 13, 2004 - v1
Checksum:i500EB551BA8F4F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07030590 Genomic DNA No translation available.
BC079036 mRNA Translation: AAH79036.1
CH473948 Genomic DNA Translation: EDM06413.1
CH473948 Genomic DNA Translation: EDM06414.1
CH473948 Genomic DNA Translation: EDM06415.1
RefSeqiNP_001007614.1, NM_001007613.1
XP_008766535.1, XM_008768313.2
UniGeneiRn.106017
Rn.162208

Genome annotation databases

EnsembliENSRNOT00000048490; ENSRNOP00000041663; ENSRNOG00000030680
GeneIDi287765
KEGGirno:287765
UCSCiRGD:619906 rat

Similar proteinsi

Entry informationi

Entry nameiQ6AYI1_RAT
AccessioniPrimary (citable) accession number: Q6AYI1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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