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Protein

Dynactin subunit 2

Gene

Dctn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mitotic cell cycle Source: RGD
  • mitotic spindle organization Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-2132295 MHC class II antigen presentation
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 2
Gene namesi
Name:Dctn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1303182 Dctn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002887662 – 402Dynactin subunit 2Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei83PhosphoserineBy similarity1
Modified residuei86PhosphotyrosineBy similarity1
Modified residuei134PhosphothreonineBy similarity1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei321PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6AYH5
PRIDEiQ6AYH5

PTM databases

iPTMnetiQ6AYH5
PhosphoSitePlusiQ6AYH5

Expressioni

Gene expression databases

BgeeiENSRNOG00000025481 Expressed in 10 organ(s), highest expression level in testis
ExpressionAtlasiQ6AYH5 baseline and differential
GenevisibleiQ6AYH5 RN

Interactioni

Subunit structurei

Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2, CEP135, DYNAP, ECPAS and MAPRE1.By similarity

Protein-protein interaction databases

BioGridi256357, 4 interactors
IntActiQ6AYH5, 3 interactors
STRINGi10116.ENSRNOP00000008120

Structurei

3D structure databases

SMRiQ6AYH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili100 – 130Sequence analysisAdd BLAST31
Coiled coili215 – 247Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the dynactin subunit 2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3958 Eukaryota
ENOG410XSZK LUCA
GeneTreeiENSGT00390000003427
HOGENOMiHOG000007303
HOVERGENiHBG051323
InParanoidiQ6AYH5
KOiK10424
PhylomeDBiQ6AYH5
TreeFamiTF105247

Family and domain databases

InterProiView protein in InterPro
IPR028133 Dynamitin
PANTHERiPTHR15346 PTHR15346, 1 hit
PfamiView protein in Pfam
PF04912 Dynamitin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q6AYH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPKYADLP GIARNEPDVY ETSDLPEDDQ AEFDAEELSS TSVEHIIVNP
60 70 80 90 100
NAAYDKFKDK RVGTKGLDFS DRIGKTKRTG YESGDYEMLG EGLGVKETPQ
110 120 130 140 150
QKYQRLLHEV QELTTEVEKI KTTVKESATE EKLTPVVLAK QLAALKQQLV
160 170 180 190 200
ASHLEKLLGP DAAINLADPD GALAKRLLLQ LEATKSSKGS SGGKSTGGTP
210 220 230 240 250
PDSSLVTYEL HSRPEQDKFS QAAKVAELEK RLTELEATVR CDQDAQNPLS
260 270 280 290 300
AGLQGACLME TVELLQAKVN ALDLAVLDQV EARLQSVLGK VNEIAKHKAS
310 320 330 340 350
VEDADTQNKV HQLYETIQRW SPVASTLPEL VQRLVTIKQL HEQAMQFGQL
360 370 380 390 400
LTHLDTTQQM MASSLKDNTA LLTQVQTTMR ENLATVEGNF ASIDARMKKL

GK
Length:402
Mass (Da):44,148
Last modified:September 13, 2004 - v1
Checksum:i550335535A4FB052
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JUC7A0A0G2JUC7_RAT
Dynactin subunit 2
Dctn2
420Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079042 mRNA Translation: AAH79042.1
RefSeqiNP_001004239.1, NM_001004239.1
UniGeneiRn.101923

Genome annotation databases

EnsembliENSRNOT00000008120; ENSRNOP00000008120; ENSRNOG00000025481
GeneIDi299850
KEGGirno:299850
UCSCiRGD:1303182 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079042 mRNA Translation: AAH79042.1
RefSeqiNP_001004239.1, NM_001004239.1
UniGeneiRn.101923

3D structure databases

SMRiQ6AYH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256357, 4 interactors
IntActiQ6AYH5, 3 interactors
STRINGi10116.ENSRNOP00000008120

PTM databases

iPTMnetiQ6AYH5
PhosphoSitePlusiQ6AYH5

Proteomic databases

PaxDbiQ6AYH5
PRIDEiQ6AYH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008120; ENSRNOP00000008120; ENSRNOG00000025481
GeneIDi299850
KEGGirno:299850
UCSCiRGD:1303182 rat

Organism-specific databases

CTDi10540
RGDi1303182 Dctn2

Phylogenomic databases

eggNOGiKOG3958 Eukaryota
ENOG410XSZK LUCA
GeneTreeiENSGT00390000003427
HOGENOMiHOG000007303
HOVERGENiHBG051323
InParanoidiQ6AYH5
KOiK10424
PhylomeDBiQ6AYH5
TreeFamiTF105247

Enzyme and pathway databases

ReactomeiR-RNO-2132295 MHC class II antigen presentation
R-RNO-2565942 Regulation of PLK1 Activity at G2/M Transition
R-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-380259 Loss of Nlp from mitotic centrosomes
R-RNO-380270 Recruitment of mitotic centrosome proteins and complexes
R-RNO-380320 Recruitment of NuMA to mitotic centrosomes
R-RNO-5620912 Anchoring of the basal body to the plasma membrane
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-8854518 AURKA Activation by TPX2

Miscellaneous databases

PROiPR:Q6AYH5

Gene expression databases

BgeeiENSRNOG00000025481 Expressed in 10 organ(s), highest expression level in testis
ExpressionAtlasiQ6AYH5 baseline and differential
GenevisibleiQ6AYH5 RN

Family and domain databases

InterProiView protein in InterPro
IPR028133 Dynamitin
PANTHERiPTHR15346 PTHR15346, 1 hit
PfamiView protein in Pfam
PF04912 Dynamitin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN2_RAT
AccessioniPrimary (citable) accession number: Q6AYH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2004
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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