UniProtKB - Q6AYH2 (IN80E_RAT)
Protein
INO80 complex subunit E
Gene
Ino80e
Organism
Rattus norvegicus (Rat)
Status
Functioni
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.By similarity
GO - Biological processi
- chromatin remodeling Source: InterPro
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
Keywordsi
Biological process | DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-RNO-5689603, UCH proteinases R-RNO-5696394, DNA Damage Recognition in GG-NER |
Names & Taxonomyi
Protein namesi | Recommended name: INO80 complex subunit EAlternative name(s): Coiled-coil domain-containing protein 95 |
Gene namesi | Name:Ino80e Synonyms:Ccdc95 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359572, Ino80e |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- Ino80 complex Source: RGD
- nucleolus Source: Ensembl
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234293 | 1 – 244 | INO80 complex subunit EAdd BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 159 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
jPOSTi | Q6AYH2 |
PaxDbi | Q6AYH2 |
PRIDEi | Q6AYH2 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000019960, Expressed in brain and 22 other tissues |
Genevisiblei | Q6AYH2, RN |
Interactioni
Subunit structurei
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027034 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 10 – 54 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 91 – 210 | Pro-richAdd BLAST | 120 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502RZ5F, Eukaryota |
GeneTreei | ENSGT00390000011918 |
HOGENOMi | CLU_099081_0_0_1 |
InParanoidi | Q6AYH2 |
OMAi | TDVEVDY |
OrthoDBi | 1299948at2759 |
PhylomeDBi | Q6AYH2 |
TreeFami | TF326931 |
Family and domain databases
InterProi | View protein in InterPro IPR026678, INO80E |
PANTHERi | PTHR21812, PTHR21812, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6AYH2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK
60 70 80 90 100
SFLLDRLLQY ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP
110 120 130 140 150
MGGAPSPSSL SLPPSSGFPL QTSGAPSPYL SSLASPPYPP FPSDYLALQL
160 170 180 190 200
PEPSPLRPKL EKRPRLPRKL KMAVGPPDCP VGGPLAFPAR GSGASVGAAL
210 220 230 240
TPLPPPKMPP HTILSTVPQQ MFSDAGSGDD ALDGDDDLVI DIPE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079045 mRNA Translation: AAH79045.1 |
RefSeqi | NP_001013922.1, NM_001013900.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027033; ENSRNOP00000027034; ENSRNOG00000019960 |
GeneIDi | 293494 |
KEGGi | rno:293494 |
UCSCi | RGD:1359572, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079045 mRNA Translation: AAH79045.1 |
RefSeqi | NP_001013922.1, NM_001013900.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027034 |
Proteomic databases
jPOSTi | Q6AYH2 |
PaxDbi | Q6AYH2 |
PRIDEi | Q6AYH2 |
Genome annotation databases
Ensembli | ENSRNOT00000027033; ENSRNOP00000027034; ENSRNOG00000019960 |
GeneIDi | 293494 |
KEGGi | rno:293494 |
UCSCi | RGD:1359572, rat |
Organism-specific databases
CTDi | 283899 |
RGDi | 1359572, Ino80e |
Phylogenomic databases
eggNOGi | ENOG502RZ5F, Eukaryota |
GeneTreei | ENSGT00390000011918 |
HOGENOMi | CLU_099081_0_0_1 |
InParanoidi | Q6AYH2 |
OMAi | TDVEVDY |
OrthoDBi | 1299948at2759 |
PhylomeDBi | Q6AYH2 |
TreeFami | TF326931 |
Enzyme and pathway databases
Reactomei | R-RNO-5689603, UCH proteinases R-RNO-5696394, DNA Damage Recognition in GG-NER |
Miscellaneous databases
PROi | PR:Q6AYH2 |
Gene expression databases
Bgeei | ENSRNOG00000019960, Expressed in brain and 22 other tissues |
Genevisiblei | Q6AYH2, RN |
Family and domain databases
InterProi | View protein in InterPro IPR026678, INO80E |
PANTHERi | PTHR21812, PTHR21812, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IN80E_RAT | |
Accessioni | Q6AYH2Primary (citable) accession number: Q6AYH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |