UniProtKB - Q6AYF7 (MFAP3_RAT)
Protein
Microfibril-associated glycoprotein 3
Gene
Mfap3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Component of the elastin-associated microfibrils.By similarity
Enzyme and pathway databases
Reactomei | R-RNO-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Microfibril-associated glycoprotein 3 |
Gene namesi | Name:Mfap3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1359463, Mfap3 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 139 | ExtracellularSequence analysisAdd BLAST | 117 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 347 | CytoplasmicSequence analysisAdd BLAST | 187 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000014868 | 23 – 347 | Microfibril-associated glycoprotein 3Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 63 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 68 ↔ 117 | PROSITE-ProRule annotation | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.Curated
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q6AYF7 |
PRIDEi | Q6AYF7 |
PTM databases
GlyGeni | Q6AYF7, 4 sites |
iPTMneti | Q6AYF7 |
PhosphoSitePlusi | Q6AYF7 |
SwissPalmi | Q6AYF7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002443, Expressed in jejunum and 21 other tissues |
Genevisiblei | Q6AYF7, RN |
Interactioni
Protein-protein interaction databases
BioGRIDi | 252088, 1 interactor |
STRINGi | 10116.ENSRNOP00000003361 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 130 | Ig-like C2-typeAdd BLAST | 84 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_0_0_1 |
InParanoidi | Q6AYF7 |
OMAi | KPHCCLF |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q6AYF7 |
TreeFami | TF333205 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6AYF7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLHYCLCIL LVVTFVPTAL VLEDVTPLGT NQSSYNASFL SSFELSAGSY
60 70 80 90 100
SGDDVIIAKE GTNVSLECLL TVDHYGEVHW YNSKGRQLHS RGGKWLVSDN
110 120 130 140 150
FLNITSVAFD DRGLYTCIIT SPTRASYSVT LRVIFTSGDM SVYYMVVCLI
160 170 180 190 200
AFTITLILNV TRLCLMSTHL RKTEKAINEF FRTEGAEKLQ KAFEIAKRIP
210 220 230 240 250
IITSAKTLEL AKVTQFKTME FARYIEELAR SVPLPPLILN CRAFVEEMFE
260 270 280 290 300
AVRVDDPDDM GERIKERPAL DAQSGIYVIN PELGRSNSPG GDSDDGSLSE
310 320 330 340
QGQEIAVQVS VHLQSETKSI GTDSQDSSHF SPPSDPASAE GSTHHRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079064 mRNA Translation: AAH79064.1 |
RefSeqi | NP_001007610.1, NM_001007609.1 XP_006246441.1, XM_006246379.2 |
Genome annotation databases
Ensembli | ENSRNOT00000003361; ENSRNOP00000003361; ENSRNOG00000002443 |
GeneIDi | 287299 |
KEGGi | rno:287299 |
UCSCi | RGD:1359463, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC079064 mRNA Translation: AAH79064.1 |
RefSeqi | NP_001007610.1, NM_001007609.1 XP_006246441.1, XM_006246379.2 |
3D structure databases
SMRi | Q6AYF7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 252088, 1 interactor |
STRINGi | 10116.ENSRNOP00000003361 |
PTM databases
GlyGeni | Q6AYF7, 4 sites |
iPTMneti | Q6AYF7 |
PhosphoSitePlusi | Q6AYF7 |
SwissPalmi | Q6AYF7 |
Proteomic databases
PaxDbi | Q6AYF7 |
PRIDEi | Q6AYF7 |
Genome annotation databases
Ensembli | ENSRNOT00000003361; ENSRNOP00000003361; ENSRNOG00000002443 |
GeneIDi | 287299 |
KEGGi | rno:287299 |
UCSCi | RGD:1359463, rat |
Organism-specific databases
CTDi | 4238 |
RGDi | 1359463, Mfap3 |
Phylogenomic databases
eggNOGi | ENOG502QW9J, Eukaryota |
GeneTreei | ENSGT00390000011576 |
HOGENOMi | CLU_056017_0_0_1 |
InParanoidi | Q6AYF7 |
OMAi | KPHCCLF |
OrthoDBi | 1154642at2759 |
PhylomeDBi | Q6AYF7 |
TreeFami | TF333205 |
Enzyme and pathway databases
Reactomei | R-RNO-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
PROi | PR:Q6AYF7 |
Gene expression databases
Bgeei | ENSRNOG00000002443, Expressed in jejunum and 21 other tissues |
Genevisiblei | Q6AYF7, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin IPR039696, MFAP3-like |
PANTHERi | PTHR14340, PTHR14340, 1 hit |
Pfami | View protein in Pfam PF00047, ig, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MFAP3_RAT | |
Accessioni | Q6AYF7Primary (citable) accession number: Q6AYF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | September 13, 2004 | |
Last modified: | August 12, 2020 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |