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Protein

Artemin

Gene

Artn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-RNO-5673001 RAF/MAP kinase cascade
R-RNO-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Artemin
Gene namesi
Name:Artn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621427 Artn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
PropeptideiPRO_000024029040 – 111Sequence analysisAdd BLAST72
ChainiPRO_0000240291112 – 224ArteminAdd BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi127 ↔ 192By similarity
Disulfide bondi154 ↔ 220By similarity
Disulfide bondi158 ↔ 222By similarity
Disulfide bondi191InterchainBy similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6AYE8
PRIDEiQ6AYE8

Expressioni

Tissue specificityi

Cochlea. Expressed at higher level in sesorineural epithelium than in the modiolus region or substantia nigra.2 Publications

Developmental stagei

Expressed during embryogenesis. At embryonic day 14 (E14) not detected in the brain or spinal cord. A striking expression seen in the nerve roots but not in the developing neurons of the dorsal root ganglia. A significant expression also seen around the superior mesentric artery.1 Publication

Gene expression databases

BgeeiENSRNOG00000019842

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds to RET (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026852

Structurei

3D structure databases

ProteinModelPortaliQ6AYE8
SMRiQ6AYE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 101Pro-richAdd BLAST59

Sequence similaritiesi

Belongs to the TGF-beta family. GDNF subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0YD Eukaryota
ENOG4111W7C LUCA
GeneTreeiENSGT00520000055559
HOGENOMiHOG000220877
HOVERGENiHBG080137
InParanoidiQ6AYE8
OMAiISQPCCR
OrthoDBiEOG091G0L16
PhylomeDBiQ6AYE8
TreeFamiTF332366

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6AYE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGLGEPTA LSHCLRPRWQ PALWPTLAAL ALLSSVTEAS LDPMSRSPAS
60 70 80 90 100
RDVPSPVLAP PTDYLPGGHT AHLCSERALR PPPQSPQPAP PPPGPALQSP
110 120 130 140 150
PAALRGARAA RAGTRSSRAR ATDARGCRLR SQLVPVSALG LGHSSDELIR
160 170 180 190 200
FRFCSGSCRR ARSPHDLSLA SLLDAGALRS PPGSRPISQP CCRPTRYEAV
210 220
SFMDVNSTWR TVDHLSATAC GCLG
Length:224
Mass (Da):23,656
Last modified:September 13, 2004 - v1
Checksum:i08907D743F651495
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174D → G in AAF01241 (PubMed:10719212).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079078 mRNA Translation: AAH79078.1
AY230412 mRNA Translation: AAO73543.1
AY230413 mRNA Translation: AAO73544.1
AF184919 mRNA Translation: AAF01241.1
RefSeqiNP_445849.1, NM_053397.1
XP_006238747.1, XM_006238685.3
XP_006238749.1, XM_006238687.3
XP_017448983.1, XM_017593494.1
UniGeneiRn.154711

Genome annotation databases

EnsembliENSRNOT00000026852; ENSRNOP00000026852; ENSRNOG00000019842
GeneIDi362572
KEGGirno:362572
UCSCiRGD:621427 rat

Similar proteinsi

Entry informationi

Entry nameiARTN_RAT
AccessioniPrimary (citable) accession number: Q6AYE8
Secondary accession number(s): Q810F6, Q810F7, Q9QZG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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